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Worcester et al. describe a suite of molecular tools and approaches that can be used to probe and experimentally study lipids.

Neomycin toxicity in eukaryotic cells stems from its binding to phosphoinositides, primarily confined to the inner leaflet of the plasma membrane. New research reveals a complex lipid-trafficking path...

Jain et al. report that the Neo1 P4-ATPase flips the lipid PI4P across the Golgi membrane to the cytosolic leaflet, preventing PI4P exposure and thereby conferring neomycin resistance.

Nature Cell Biology - Jain et al. report that the Neo1 P4-ATPase flips the lipid PI4P across the Golgi membrane to the cytosolic leaflet, preventing PI4P exposure and thereby conferring neomycin...