Abstract. Polycomb repressive complex 1 (PRC1) forms nuclear condensates that organize target chromatin domains. SUMOylation modulates PRC1 clustering, but

Cell Discovery - PRC1 nanoglobules organize Hox chromatin during Drosophila embryogenesis

Understanding the interplay between cell fate specification and morphogenetic changes remains a central challenge in developmental biology. Gastruloids, self-organizing stem cell-based models of post-...

In some cases, non-genetic information can be inherited across generations. Fitz-James et al. investigate the mechanism by which such epigenetic information becomes heritable in fruit flies. They show that physical contact between regions of DNA within the cell is able to trigger the histone modification H3K27me3 to become heritable.

PhD Project - How is epigenetic information inherited across generations in insects? at University of Oxford, listed on FindAPhD.com

Bats are the only mammals capable of self-powered flight, an evolutionary innovation based on the transformation of forelimbs into wings. The bat wing is characterized by an extreme elongation of the ...

Szalay et al. discuss cross-kingdom similarities and differences in 3D chromatin folding in relation to gene regulation, including in bacteria, archaea, mammals and plants. This comparison reveals cer...