Reposted by Bella LinAndrea Vettiger @avettiger.bsky.social · 06/10/2026I am delighted to share our latest paper on mycomembrane protein assembly which came out last week in @pnas.org This was a fantastic collaboration between my former colleague, Elizabeth (#Betsy) Hart, and my first PhD student, Dieuwertje (#Didi) de Bruin. www.pnas.org/doi/10.1073/... (1/n)pnas.org 1228
Reposted by Bella LinHeather Feaga @heatherfeaga.bsky.social · 15/09/2026Latest from the lab! Kevin England @kevinengland.bsky.social leads a study on how production of various alarmones (p,pp,pppGpp!) depletes GTP, remodels the transcriptome, and inhibits translation. Wonderful collaboration with Jade Wang's lab at UW Madison. academic.oup.com/nar/article/...academic.oup.comThe alarmone pGpp inhibits translation through GTP depletionAbstract. Bacteria produce the alarmone nucleotides ppGpp and pppGpp during stress to affect replication, transcription, and metabolism. ppGpp and pppGpp a 0238
Reposted by Bella LinKevin England @kevinengland.bsky.social · 13/09/2026Our paper (and my first first-author) is out! The alarmone pGpp inhibits translation through GTP depletion academic.oup.com/nar/article/... 🦠🚨🤠 @narjournal.bsky.socialacademic.oup.com 23520
Reposted by Bella LinbioRxiv Biophysics @biorxiv-biophys.bsky.social · 28/08/2026Structural basis for nutrient-activated channel opening in bacterial spore germination receptors www.biorxiv.org/content/10.64898/20… 01110
Reposted by Bella Linanna brogan @apbrogan.bsky.social · 18/08/2026This is now published! For those interested in microbial mechanotransduction: www.cell.com/current-biol...cell.comMicrobial GAIN domains undergo autoproteolysis and enable release of diverse cell-surface-associated proteinsBrogan and Rudner report the identification of a microbial autoproteolytic domain that is structurally homologous to the GAIN domain of eukaryotic adhesion GPCRs. Rather than participating in transmem... 13921
Reposted by Bella Linanna brogan @apbrogan.bsky.social · 23/06/2026Another chapter of my thesis is out! We asked whether we could pair proteome-wide AlphaFold screening with Tn-seq to identify biologically relevant protein-protein interactions. We identify ClcR (formerly YerH) as a component of the Rod complex in Gram-positive bacteria. www.pnas.org/doi/10.1073/...pnas.orgA broadly conserved gram-positive lipoprotein regulates cell elongation | PNASThe cell wall peptidoglycan (PG) protects virtually all bacteria from osmotic lysis and specifies cell shape. Synthesis of this exoskeleton is carr... 15827
Reposted by Bella LinHeather Feaga @heatherfeaga.bsky.social · 16/04/2026I’m so honored to be included in this Hypothesis Fund cohort and grateful for this investment in our research! 🥲 3257
Reposted by Bella LinGeorge O'Toole (he/him/his) @geiselbiofilm.bsky.social · 04/02/2026rince & JB Editor's Choice: Lin, Prince & Feaga identified sporulation genes via analyzing almost 1500 genomes. They show that that an unusual membrane-localized variant of Spo0B is found throughout Paenibacillaceae. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology 02611
Reposted by Bella LinHeather Feaga @heatherfeaga.bsky.social · 30/12/2025The sporulation phosphorelay protein Spo0B is membrane localized in Paenibacillus! The transmembrane domain appears to increase interaction with relay partners. Congrats to former lab undergrad @isabellalin.bsky.social and her grad mentor @cassidyprints.bsky.social journals.asm.org/doi/10.1128/...journals.asm.org 02516
Reposted by Bella LinHeather Feaga @heatherfeaga.bsky.social · 29/08/2025Here we show that >90% of Paenibacillus encode a unique Spo0B with a transmembrane domain! TM domain helps it interact with its phosphorelay partners. Congrats to @isabellalin.bsky.social who left for grad school this week and her mentor @cassidyprints.bsky.social! www.biorxiv.org/content/10.1...biorxiv.orgConservation of sporulation genes and a transmembrane-containing Spo0B variant in PaenibacillusSporulation is a strategy employed by many bacteria to survive harsh environmental conditions. The genus Paenibacillus includes spore-forming species notorious for spoiling pasteurized dairy products ... 32716
Reposted by Bella LinHeather Feaga @heatherfeaga.bsky.social · 11/03/2025Bella Lin @isabellalin.bsky.social will be attending Harvard BBS for her PhD!! We’re so proud of you Bella! 🍾🎉 0131
