Nature Reviews Endocrinology, Published online: 13 April 2026; doi:10.1038/s41574-026-01249-6In this Review, the authors describe how the development of various thyroid organoid models has advanced research into thyroid development, dysregulation and disease. They also discuss the limitations of these models and whether thyroid organoids could be used as cell therapy in the future.

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Background: Although patients with anaplastic thyroid cancer (ATC) generally have a poor prognosis and there are currently no effective treatment options, survival and response to therapy vary between...

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Advanced thyroid carcinoma

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The experience with PARP inhibitors provides evidence of the clinical utility of synthetic lethality, whereby the simultaneous presence of two specific alterations is required for antitumour activity....