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IMR Press @imrpress.com · 25/09/2026

📄 Read the full commentary: www.imrpress.com/journal/RCM/27/9/1… ✍️ Author: Zhonghua Sun

Flowchart of the multi-granularity masked autoencoder (MGMAE) framework for self-supervised coronary artery segmentation. Pretraining stage (top): global and local masked autoencoders apply random masking to 128×128×128 and 16×16×16 volumes, with transformer encoders/decoders, reconstruction losses and a contrastive loss. Fine-tuning stage (bottom): an UNETR decoder with topological modules and nuclear-norm minimization (NNM) produces the restored blood vessel region, compared with ground truth.

IMR Press @imrpress.com · 25/09/2026

❤️ When calcium obscures the coronary arteries, can AI help reveal the truth? Heavy coronary calcification remains a major challenge in CCTA interpretation. A commentary explores how deep learning may improve calcified plaque assessment and diagnostic performance. #Cardiology #AI #MedicalImaging

True-positive case of deep learning detection of obstructive coronary stenosis (≥50%). Panels A–C show curved planar reconstruction and transverse CT views of the left anterior descending (LAD) artery with a calcified plaque (arrow) and green cross-section lines drawn at 1-mm intervals; panel D shows the corresponding quantitative coronary angiography confirming >70% luminal stenosis.

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IMR Press @imrpress.com · 25/09/2026

🧠 Early diagnosis needs both biomarkers and human care. Explore RN's featured work on CSF profiles, plasma p-tau217 and shared care planning in the World Alzheimer's Day Special Feature. 📚 Explore the special feature: www.imrpress.com/page/WAM-special-f… #Neuroscience #WorldAlzMonth

Banner for the World Alzheimer's Day Special Feature on a dark navy blue background, showing the title "World Alzheimer's Day Special Feature", the tagline "The Earlier You Know, The More You Can Do", and the date 21 September 2026 in white and light blue text.

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IMR Press @imrpress.com · 21/09/2026

🧠 Earlier knowledge can change the dementia journey. The 2026 theme: "The Earlier You Know, The More You Can Do: A Dementia Diagnosis Matters." Let's make timely diagnosis part of compassionate care. #DementiaDiagnosisMatters #AlzheimerDiagnosisMatters #EarlyDiagnosisMatters #WorldAlzMonth

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IMR Press @imrpress.com · 18/09/2026

🧠 In epilepsy, immobility is not one behavior with one cause. Male WAG/Rij rats showed more passive responses and SWDs under threat. Only females linked passive coping to later safe-context freezing (r=0.83, p<0.005). Neither correlated with SWD number or duration. #EpilepsyResearch

Figure with three panels comparing male and female WAG/Rij rats in an epilepsy model. Panel A shows more passive reactions in males in an unsafe environment. Panel B shows freezing percentages by age in a safe environment. Panel C shows a strong positive correlation between passive reactions and safe-context freezing in females (r=0.83, p=0.00008), but not in males (r=0.19, p=0.63).

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IMR Press @imrpress.com · 17/09/2026

🤔 Why do stroke patients with similar infarcts recover differently? 📌 A new FBL review introduces a phase-specific immune-metabolic framework: 1️⃣ Neuroinflammation & BBB status. 2️⃣ The Gut-Brain-Metabolic Axis. 🔗 www.imrpress.com/journal/FBL/31/8/1… #Stroke #Neuroscience

Fig 1: Proposed systems-level framework for multimodal biomarker integration in precision stroke recovery, linking inflammatory/immune markers (CRP, IL-6, TNF-alpha, NLR), metabolic and nutritional markers, the gut-brain-metabolic axis (microbial diversity, SCFAs, TMAO), and neuroplasticity/repair candidates (BDNF, VEGF, GDF-10), with arrows indicating proposed interactions as a hypothesis-generating model.

Fig 4: Mechanisms of blood-brain barrier dysfunction after cerebral ischemia, contrasting physiological barrier integrity maintained by claudin-5, occludin, and ZO-1 with ischemia-induced endothelial dysfunction, MMP-9-mediated basement membrane remodeling, paracellular leakage, and a positive-feedback inflammatory loop.

Fig 7: Proposed gut-brain-metabolic pathways influencing neuroinflammation and recovery after stroke, showing post-stroke gut dysbiosis and impaired gut barrier allowing microbial metabolites (SCFAs, TMAO) and LPS to modulate microglial homeostasis, astrocyte reactivity, and neuroplasticity.

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IMR Press @imrpress.com · 16/09/2026

❤️ Beyond the limbs: could lipedema affect the cardiovascular system? Lipedema is underdiagnosed, mistaken for obesity or lymphedema. The review covers myocardial, valvular, and vascular abnormalities. 📄 Read more: www.imrpress.com/journal/RCM/27/9/1… #Cardiology #WomenHealth

$Three-dimensional speckle-tracking echocardiographic assessment of left ventricular parameters in lipedema, showing apical 4-chamber, 2-chamber, and short-axis views, a 3D ventricular model, volumes, ejection fraction, and strain curves.$ $Three-dimensional speckle-tracking echocardiographic assessment of left atrial parameters in lipedema, showing left atrial volumes, ejection fraction, and strain curves across the cardiac cycle.$ Assessment of mitral annular dimensions by three-dimensional speckle-tracking echocardiography in apical 4-chamber and 2-chamber long-axis views in a lipedema patient.

Assessment of mitral annular dimensions by three-dimensional speckle-tracking echocardiography in apical 4-chamber and 2-chamber long-axis views in a lipedema patient.

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IMR Press @imrpress.com · 31/08/2026

❤️ Direct Oral Anticoagulants Versus Vitamin K Antagonists for Treatment of Left Ventricular Thrombus: A Review of Efficacy and Safety 📄 Read more: www.imrpress.com/journal/RCM/27/8/1… #Cardiology #Thrombosis

Infographic titled "Histological Evolution of Acute Myocardial Infarction" showing the cardiac infarction site and four post-infarction time points: 0–12 hours, 12–72 hours, 1–3 weeks, and >1 month. The panels illustrate wavy, stretched cardiomyocytes and beginning necrotic coagulation; neutrophil infiltration and culmination of necrotic coagulation; disintegration of necrotic myocytes with granulation tissue formation; and formation of a fibrous scar with fewer cells and abundant collagenous fibers.

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IMR Press @imrpress.com · 27/08/2026

read more：https://www.imrpress.com/journal/RCM/27/8/10.31083/RCM51668#F010 ✍️ Authors: Yuki Komatsu, @AkihikoNogami

Composite figure with two 3D electroanatomical substrate maps of the left ventricle (mitral valve "MV" and apex labeled): (left) bipolar voltage map highlighting low-voltage scar areas in red, (right) second map showing the same anatomy with a green marker indicating the "Success site" of VT ablation. Below, a continuous 12-lead ECG (leads I–V6) with MAP 1–2 intracardiac recording illustrates VT termination at the ablation site (red arrow, dashed line).

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IMR Press @imrpress.com · 27/08/2026

Ablation of the area encompassing the critical conduction abnormality related to the targeted VT.

Three 3D voltage maps of the left ventricle showing the evolution of the ablation strategy: (A) initial voltage map with a low-voltage region outlined; (B) refined color map highlighting the critical conduction abnormality area; (C) post-ablation map (blue arrow) with the targeted ablation zone now covered by red ablation lesions (white circle).

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IMR Press @imrpress.com · 27/08/2026

Visualization of the deceleration zone by changing the annotation strategy

Three-panel figure comparing activation maps: (A) sinus-rhythm map with near-field annotation, (B) sinus-rhythm map with last-deflection annotation, (C) VT activation map with labeled points a–d and intracardiac electrograms (colored traces) showing late activation in the deceleration zone. Color scale 0–200 ms.

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IMR Press @imrpress.com · 27/08/2026

Annotation of the diastolic potentials during VT activation mapping

Side-by-side comparison of two annotation strategies on a 3D voltage map: (Left) "Near Field annotation" using QRS offset-to-offset window-of-interest, with numbered recording sites 1–7 and corresponding intracardiac electrograms showing diastolic signals (white dashed arrows, red arrows). (Right) "First Deflection annotation" using QRS offset-to-offset window, yielding a different highlighted ablation target area with distinct diastolic potential timing.

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IMR Press @imrpress.com · 27/08/2026

Advanced mapping helps distinguish: 🔹 Dense scar 🔹 Border zones 🔹 Critical conduction pathways The goal: find the circuits that actually sustain VT.

Five-panel 3D electroanatomical mapping series of the left ventricle (apex, septum, LV lateral labeled) showing different voltage maps (A–E) that distinguish dense scar, border zones, and critical conduction pathways. Panels D–E include intracardiac electrograms and surface ECG (I, II, III, aVR, aVL, aVF, V1–V6) corresponding to the highlighted regions.

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IMR Press @imrpress.com · 27/08/2026

A scar can become an electrical maze. After myocardial injury, areas of fibrosis and surviving myocardium may form the substrate responsible for ventricular tachycardia. Identifying this substrate is the foundation of modern VT ablation strategies.

Three-panel figure: (A, B) 12-lead surface ECG with intracardiac recordings (MAP 1–2, Micro 1–3) labeled with "near field" and "far field" diastolic potentials marked by blue and red arrows; (C) biplane fluoroscopic images (RAO top, LAO bottom) showing multipolar mapping catheter positions within the cardiac chambers, with red arrows pointing to catheter tip locations.

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IMR Press @imrpress.com · 27/08/2026

❤️ Where does ventricular tachycardia hide? A myocardial scar is not just damaged tissue. Within the scar, surviving myocardial fibers can create hidden electrical pathways that sustain VT. This thread explores how 3D mapping reveals these arrhythmogenic circuits. #Cardiology #Electrophysiology

Six-panel electrophysiology figure showing VT ablation steps: (A) 3D electroanatomical voltage map of the left ventricle with color-coded scar; (B) 12-lead surface ECG with Pacemap; (C) intracardiac electrograms (MAP, CS, RV catheters) with a diastolic potential marked by a red arrow and a dashed annotation line; (D) 3D voltage map showing a linear ablation lesion (red dots) labeled a–d at the VT exit site; (E) Pacemap after apical linear ablation; (F) exit block confirmed after basal linear ablation.

Side-by-side local activation time (LAT) maps showing rotational activation pattern: left, substrate map during RV-paced rhythm (39–214 ms color scale); right, same heart in VT with a 3D rotor and decapolar recording channels at the bottom. Surface ECG leads I–V6 displayed on the right.

Two 3D maps comparing propagation patterns: (A) BiV-paced rhythm and (B) RV-paced rhythm. Yellow dotted arrows show rotational/scrolling activation wavefronts and red arrows mark conduction pivots, illustrating how pacing modality alters the apparent reentrant circuit.

Three-panel figure: (A) sinus-rhythm voltage map with low-voltage scar region outlined; (B) S1 and S2 pacing maps showing differential conduction into the low-voltage zone; (C) clinical VT 12-lead ECG paired with an "excellent pacemap" at the opposite RV septum, a "poor pacemap" at the LV septum, and decapolar recordings at the RV septum that match the VT morphology.

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IMR Press @imrpress.com · 25/08/2026

After #LACC, does MIS still have a place in early-stage #CervicalCancer? 📉 Final LACC analysis: MIS 4.5-yr DFS 85% vs open 96% (HR 3.91) — open surgery remains the standard. 📊 But in low-risk ≤2 cm disease, MIS matched open: 5-yr OS 98.6% vs 99.3% (p=0.571).

First page of the editorial "Beyond LACC: Is There Still a Role for Minimally Invasive Surgery in Early-Stage Cervical Cancer?" by Simone Ferrero, Fabio Barra, and Valerio Gaetano Vellone, published in Clinical and Experimental Obstetrics & Gynecology 2026; 53(8); 53908. Two-column layout showing title, authors, affiliations (Azienda Ospedaliera Metropolitana, University of Genova, IRCCS-Istituto Giannina Gaslini, all Genoa, Italy), academic editors (Yasuhiko Ebina, Michael H. Dahan), submission/acceptance/publication dates (15 May / 2 June / 31 July 2026), and the introductory text discussing the LACC trial findings and minimally invasive surgery in early-stage cervical cancer.

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IMR Press @imrpress.com · 21/08/2026

📄 Read more: www.imrpress.com/journal/RCM/27/8/1… ✍️ Authors: Fotios Toulgaridis @ftoulga, Nikolaos Tsiamis, Dimitrios Afendoulis, Flora Tsakirian, Sotirios Kotoulas, Christo Kole, Ioannis Andreou

Infographic titled "Stent Undersizing and Malapposition: Mechanical Causes of Acute and Late Stent Failure" showing three deployment scenarios (optimal, undersizing/underexpansion, malapposition with visible gap), causes of malapposition (acute: inadequate sizing, insufficient lesion preparation, calcification, thrombus burden; chronic: thrombus resolution, positive vessel remodeling, hypersensitivity, late acquired malapposition), clinical consequences cascade (disturbed blood flow → impaired endothelialization → platelet activation & thrombus → stent thrombosis → in-stent restenosis → target lesion failure), detection methods (Angiography limited, OCT gold standard, IVUS), and treatment strategies (lesion preparation, ICI-guided sizing, high-pressure post-dilatation, intravascular lithotripsy for calcification).

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IMR Press @imrpress.com · 21/08/2026

❤️ A successful PCI is more than a good angiographic result. Stent undersizing and malapposition may remain hidden after implantation. 1️⃣ Mechanical defects can drive stent failure 2️⃣ OCT/IVUS improve stent optimization 3️⃣ Imaging-guided PCI enables mechanism-based decisions #Cardiology #PCI #OCT

Four-step infographic titled "Management of Stent Undersizing and Malapposition" showing: (1) appropriate vessel sizing using OCT/IVUS intracoronary imaging with lumen measurement and stent size selection; (2) lesion preparation with calcium-modifying techniques (RA/OA/IVL); (3) high-pressure post-dilatation with non-compliant balloon at ≥18 atm; (4) re-intervention for late malapposition assessed at 6–12 month follow-up imaging.

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IMR Press @imrpress.com · 20/08/2026

📄 Read more: www.imrpress.com/journal/RCM/27/8/1… ✍️ Authors: Lazar Mandinov, Chris A. Learn 🏛 Affiliations: Cardiovascular Therapeutic Area, Parexel, Newton, MA, USA; Cell and Gene & Early Phase Therapeutic Area, Parexel, Raleigh, NC, USA

Infographic summarizing inflammation in atherosclerosis: lipid retention, NLRP3 activation, clinical trial results, therapeutic targets, translational challenges and future precision-treatment strategies.

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IMR Press @imrpress.com · 20/08/2026

🧬 Targeting inflammation: emerging strategies in ASCVD therapy Potential approaches include: 1️⃣ IL-1β inhibition 2️⃣ IL-6–targeted therapies 3️⃣ NLRP3 inflammasome inhibitors The goal: reducing residual inflammatory risk beyond lipid lowering.

Diagram of the NLRP3–IL-1β–IL-6 inflammatory pathway in atherosclerosis and the therapeutic pipeline, including IL-1, IL-6 and NLRP3 inhibitors, biomarkers and clinical endpoints.

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IMR Press @imrpress.com · 20/08/2026

❤️ Atherosclerosis is not only lipid-driven—it is also shaped by chronic inflammation. Inflammation contributes to plaque progression and residual cardiovascular risk. The NLRP3 inflammasome–IL-1β–IL-6 pathway is shaping emerging strategies for ASCVD. #Cardiology #Atherosclerosis

Diagram illustrating atherosclerosis initiation, inflammatory signaling and plaque progression, including LDL retention, immune-cell activation, the NLRP3 inflammasome, IL-1β and vascular smooth muscle cells.

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IMR Press @imrpress.com · 13/08/2026

🧐Can glutamatergic modulators complement, not replace, dopamine blockade in schizophrenia? #Schizophrenia New debate in Alpha Psychiatry: 1️⃣ #NMDAR hypofunction may make #glutamate an upstream driver. 2️⃣Value lies in complementing, not supplanting, antipsychotics. #PrecisionMedicine #Neuroscience

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IMR Press @imrpress.com · 12/08/2026

🔬Post-symptomatic genistein improved behavioral, neuromuscular, and biochemical measures in female R6/1 mice modeling Huntington’s disease. 🔍The preclinical findings support further research. 🔗Read: imrpress.com/journal/FBL/... #HuntingtonsDisease #Neuroscience

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IMR Press @imrpress.com · 11/08/2026

❤️ Can sleep apnoea drive atrial fibrillation? OSA and AF often coexist through shared mechanisms. 1️⃣Intermittent hypoxia → atrial remodeling 2️⃣Inflammation & autonomic imbalance → arrhythmia risk 3️⃣Risk-factor management may improve outcomes #Cardiology #AtrialFibrillation

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IMR Press @imrpress.com · 07/08/2026

🕸️3,021 neurons, 33 functional clusters. A systematic atlas of mouse visual thalamus reveals how superior colliculus shapes diverse encoding across cell types. 📄 imrpress.com/journal/JIN/... #Neuroscience #Vision #dLGN

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IMR Press @imrpress.com · 07/08/2026

❤️GLP-1 RAs: beyond diabetes. 1️⃣ Obesity – sustainable weight loss 2️⃣ ASCVD – MACE ↓20% (SELECT) 3️⃣ CKD – renal events ↓24% (FLOW) 4️⃣ MASLD – histologic improvement 5️⃣ OSA – FDA‑approved (tirzepatide) ⚠️ Caution in HFrEF. imrpress.com/journal/RCM/... #Obesity #Cardiology

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IMR Press @imrpress.com · 04/08/2026

🫀Percutaneous coronary intervention (PCI) after 1 year: what next? 1️⃣Balance ischemic & bleeding risks 2️⃣P2Y12 monotherapy may outperform aspirin 3️⃣High-risk patients need tailored strategies 💡One timeline ≠ all patients. imrpress.com/journal/RCM/... #Cardiology #PCI

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IMR Press @imrpress.com · 04/08/2026

Credible research deserves recognition and visibility. IMR Press is now on Bluesky. We'll share peer-reviewed research from FBL, RCM, CEOG, JIN, AP and more, alongside practical insights on open access and research integrity. Follow for research worth discovering.

IMR Press, an international academic publisher, is now on Bluesky.

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