Happy to share that our review on the structural biology of T-cell surface proteins is out in Immunological Reviews.
Here we describe the ways in which crystal structures and cryo-EM have informed our understanding of receptor behaviour and T-cell biology.
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
The Structural Biology of T‐Cell Antigen Detection at Close Contacts
T cells physically interrogate their targets using tiny membrane protrusions called microvilli, forming junctions ~400 nm in diameter and ~ 15 nm deep, referred to as “close contacts”. These contacts...
