iiinova — where your digital self keeps evolving

Reposted by Ivona Glavincheska

James McInerney @jomcinerney.bsky.social · 29/08/2025

New preprint reveals bacteria can't just collect all resistance genes like Pokemon cards. We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...

biorxiv.org

Genomic constraints shape the evolution of alternative routes to drug resistance in prokaryotes

Background Variation within the prokaryotic pangenome is not random, and natural selection that favours particular combinations of genes appears to dominate over random drift. What is less clear is wh...

416577

Reposted by Ivona Glavincheska

kasitc.bsky.social @kasitc.bsky.social · 18/08/2025

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

29839

Reposted by Ivona Glavincheska

Justin Blumenstiel @bdelloid.bsky.social · 16/08/2025

The original circos plot? From the 1947-1948 Carnegie Yearbook, the page prior to McClintock's Mutable Loci in Maize paper.

An old image of a salivary gland chromosome from Drosophila melanogaster, with lines across different segments indicating contact points.

48735

Reposted by Ivona Glavincheska

Toby Baril @tobybarilbio.bsky.social · 07/08/2025

1/ Excited to share our latest opinion piece published today in Trends in Microbiology (@cp-trendsmicrobiol.bsky.social): Hypermutator fungal pathogens: from threat to meltdown Here, we argue that the origin of hypermutation follows defined principles, rather than...

1128

Reposted by Ivona Glavincheska

Josje Romeijn @jromeijn.bsky.social · 20/06/2025

The first paper of my PhD is now available as a preprint! 🎉 Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.

biorxiv.org

710245

Reposted by Ivona Glavincheska

Cecile Lorrain @ccilelorrain.bsky.social · 18/05/2025

Excited to share the first PhD preprint of @iglavincheska.bsky.social — now on bioRxiv! We explored the 3D genome of Zymo and found: 🧬 Rabl-like conformation 🧩 Accessory chr tethered to core centromeres 🏰 Self-interacting domains and boundaries with insulator motifs www.biorxiv.org/content/10.1...

01711