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ifernandezrebollo.bsky.social

@ifernandezrebollo.bsky.social

ifernandezrebollo.bsky.social @ifernandezrebollo.bsky.social · 30/06/2026

Huge thanks to my co-first author @alessandrodigilio.bsky.social. I’m also very grateful to @aoikonomou.bsky.social, my supervisor @francescoiorio.bsky.social and @ioriolab.bsky.social from @humantechnopole.bsky.social, and @manelesteller.bsky.social for their guidance and support.

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ifernandezrebollo.bsky.social @ifernandezrebollo.bsky.social · 30/06/2026

www.biorxiv.org/content/10.6...

biorxiv.org

A Generalised Epigenetic Clock Reveals Therapeutic Vulnerabilities Linked to Ageing in Cancer Cells

Epigenetic clocks estimate biological age from DNA methylation patterns but perform poorly in cancer due to extensive epigenetic reprogramming, limiting the study of ageing in tumour biology. Here, we...

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ifernandezrebollo.bsky.social @ifernandezrebollo.bsky.social · 30/06/2026

Excited to share our new bioRxiv preprint! We present GepiClock, an epigenetic clock trained on cancer methylomes predicting age in both cancer and normal samples outperforming previous clocks. Applied to cancer cell lines, it reveals age-linked gene dependencies and drug response vulnerabilities.

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