PDZ domains canonically recognize short C-terminal peptide motifs, but numerous non-canonical binding mechanisms have also been described. We previously identified a direct interaction between the cel...

RAS GTPases regulate cellular activity through the selective activation of effectors, yet identifying proteins directly recruited by small GTPases in cells remains challenging. Current approaches rely...

Despite therapeutic advances against RAS mutations in cancer, acquired resistance frequently arises. Several secondary mutations at the binding sites effectively confer resistance to both Switch-II in...

Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55

PDE6D is a trafficking chaperone of prenylated proteins. Current small molecule PDE6D inhibitors target its hydrophobic pocket, rendering them typically poorly water soluble. Herein, PDE6D binders ar...

Advanced technologies to study protein biophysics, mRNA expression and protein-protein interactions at high throughput in physiological or pathological conte...

PhD Position – Cancer Signalling and Structural Biology Institute for Research in Immunology and Cancer (IRIC), Université de Montréal My lab is seeking a highly motivated PhD student to join our mult...

Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...

Open Letter from Canadian Researchers to the Federal party leaders Click here to sign this letter See who has signed - version française se trouve à page 3 - Dear Party Leaders We, the undersigne...

Posttranslational modification of proteins plays a fundamental role in cell biology. It provides cells a means to regulate the signaling, enzymatic or structural properties of proteins without cont...