iiinova — where your digital self keeps evolving

Hugues Nury @hugbum.bsky.social · 13/01/2026

Collègues du @cnrs.fr, où trouver des ressources pour apprendre à utiliser Emmy/Mistral pour aider à écrire du code ?

Reposted by Hugues Nury

Andrew Plested @andrewplested.bsky.social · 05/06/2025

The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology. Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available. ! Please share widely !

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Hugues Nury @hugbum.bsky.social · 25/06/2025

The place where I work is hiring an expert in AI applied to the de novo design of proteins: urls.fr/DpLCMY Excellent structural biology environment, amazing city surrounded by mountains.

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Reposted by Hugues Nury

Membrane Enzymology @membraneenzymology.bsky.social · 13/05/2025

Solène’s 4.5 years of postdoctoral work in our lab (she started just before the corona pandemic) has now been published. A heroic effort that revealed -at the single molecule level- that ATP drives the dissociation of an ECF transporter complex under turnover conditions. See rdcu.be/elTKc

rdcu.be

Single-molecule visualization of ATP-induced dynamics of the subunit composition of an ECF transporter complex under turnover conditions

Nature Communications - The association and dissociation dynamics of the ECF transporter complex for vitamin B12 are visualized by single-molecule FRET, highlighting the original transport...

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Hugues Nury @hugbum.bsky.social · 05/05/2025

🧪 Question for ion channels people: is it possible to use the membrane potential-sensitive FLIPR dyes in cytometry? Any protocol or reference to get started?

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Hugues Nury @hugbum.bsky.social · 18/04/2025

I used to love science fiction, and some books describing AI-governed worlds left a lasting impression on me (Ian M Banks, John Varley, ...). I enjoyed this short story about AI takeover, despite - or perhaps because of - its dead-serious academic tone. ai-2027.com

ai-2027.com

AI 2027

A research-backed AI scenario forecast.

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Hugues Nury @hugbum.bsky.social · 27/03/2025

Our long term aim is to help develop environmentally benign insecticidal proteins. This mechanistic work is a first big milestone!

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Hugues Nury @hugbum.bsky.social · 27/03/2025

A fungal-derived compound, ChroB, has an unanticipated mode-of-action (only two were known for GABAA targeting insecticides, since the 1950s) through a site that resembles the neurosteroid mammalian site. And nearby, a new PIP2 site.

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Hugues Nury @hugbum.bsky.social · 27/03/2025

Abamectin binds to the “classical” insecticide modulation site, where the bulk of resistant mutants are found. This -mectin bound structure is closed at the hydrophobic gate, unlike others.

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Hugues Nury @hugbum.bsky.social · 27/03/2025

The GABA-bound receptor looks so much like human receptors at the site level. Many site mutations surprisingly cause spontaneous activation. The pore helices are weirdly arranged (look at Fig. 5)

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Hugues Nury @hugbum.bsky.social · 27/03/2025

New preprint! @tatilab.bsky.social imaged the honeybee GABAA RDL receptor. ~10% of insecticides target insect GABAA receptors. She found a new allosteric modulation pocket, a PIP2 site, a closed avermectin-bound conformation, and maybe an unusual desensitized state. www.biorxiv.org/content/10.1...

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Hugues Nury @hugbum.bsky.social · 03/12/2024

New preprint describing a primed nicotinic receptor state with only one agonist bound, seen at low [agonist]. My fav part: ~7% of particles are in that state on cryoEM grids... that's also the proportion predicted from the fitting of single-channel data! Work led by @mackthompson88.bsky.social

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Hugues Nury @hugbum.bsky.social · 13/11/2024

What examples would you include in a short lecture on transporters? My current ones are P4-ATPase and EAATs. Suggestions involving different techniques on top of multistate cryoEM particularly appreciated!

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