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Tatiana Labouré

@tatilab.bsky.social

61 followers 200 following 0 posts

Structural biology, Membrane proteins, CryoEM & ET Currently doing my PostDoc at the UNIL, Lausanne

Posts Replies Media

Reposted by Tatiana Labouré

Hugues Nury @hugbum.bsky.social · 27/03/2025

A fungal-derived compound, ChroB, has an unanticipated mode-of-action (only two were known for GABAA targeting insecticides, since the 1950s) through a site that resembles the neurosteroid mammalian site. And nearby, a new PIP2 site.

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Reposted by Tatiana Labouré

Hugues Nury @hugbum.bsky.social · 27/03/2025

Our long term aim is to help develop environmentally benign insecticidal proteins. This mechanistic work is a first big milestone!

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Reposted by Tatiana Labouré

Hugues Nury @hugbum.bsky.social · 27/03/2025

New preprint! @tatilab.bsky.social imaged the honeybee GABAA RDL receptor. ~10% of insecticides target insect GABAA receptors. She found a new allosteric modulation pocket, a PIP2 site, a closed avermectin-bound conformation, and maybe an unusual desensitized state. www.biorxiv.org/content/10.1...

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