iiinova — where your digital self keeps evolving

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Alt CDC (they/them) @altcdc.altgov.info · 17/06/2025

👀 Hot off the press: A scathing open letter co-authored by all 17 former ACIP members. It's a frank look at ACIP history and the hard truths America will grapple with in the upcoming months. Turns out the former ACIP members have more spine than CDC leadership 🙄 jamanetwork.com/journals/jam...

jamanetwork.com

Advisory Committee on Immunization Practices at a Crossroads

In this Viewpoint, former members of the Advisory Committee on Immunization Practices (ACIP) caution that the sudden change in the ACIP may reverse the achievements of US immunization policy, includin...

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Jeremy Berg @jeremymberg.bsky.social · 23/04/2025

ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n

media.tenor.com

the word alert is in a purple circle

ALT: the word alert is in a purple circle

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Katherine Stefanski @kmstefanski.bsky.social · 26/03/2025

Calling all membrane/membrane protein folks! Join us this summer in Barcelona for the Membrane Protein Folding Gordon Conference and Seminar. GRS chaired by @justmwest.bsky.social and myself! We are soliticiting abstracts from trainees for talks! Deadline - April 6. www.grc.org/membrane-pro...

grc.org

2025 Membrane Protein Folding (GRS) Seminar GRC

The 2025 Gordon Research Seminar on Membrane Protein Folding (GRS) will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.

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James Fraser @fraserlab.com · 16/03/2025

Since @stephanieaw.bsky.social left the lab to start her group at Vanderbilt, we've been talking regularly on the ups and downs of academic science. We started recording... The Tortured Proteins Department open.spotify.com/show/10PHVou... (science with a small dose of running and Taylor Swift)

open.spotify.com

The Tortured Proteins Department

Podcast · Stephanie Wankowicz · A deep dive into scientific discovery and the process of doing science, hosted by Stephanie Wankowicz and James Fraser.

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John Skiles Skinner @skiles.blue · 01/03/2025

I got laid off today, with the rest of 18F. 18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it. We made this website to tell our story: 18f.org

18f.org

We're not done yet | 18F

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Emmanuel Margeat @emmanuelmargeat.bsky.social · 24/02/2025

I took the stage at the #BPS2025 meeting in solidarity with our american colleagues. On March 7th, events and protests are organized in US and other countries, including France, to #standupforscience @standupforscience.bsky.social @standupforscifr.bsky.social

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Karen Hao @karenhao.bsky.social · 21/02/2025

For decades, the US government has painstakingly kept American science #1 globally—and every facet of American life has improved because of it. The internet? Flu shot? Ozempic? All grew out of federally-funded research. Now all that's being dismantled. 1/ www.technologyreview.com/2025/02/21/1...

technologyreview.com

The foundations of America’s prosperity are being dismantled

Federal scientists warn that Americans could feel the effects of the new administration's devastating cuts for decades to come

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James Fraser @fraserlab.com · 31/01/2025

Thrilled to take a break from doom and gloom to share our latest work collaborating with the DeGrado lab! We took a de novo designed protein, screened it for ligand binding using X-rays, and used the hits to evolve two wildly different functions: fluorescent turn-on and Kemp elimination catalysis. 🧵

A diagram illustrating the evolution of protein functionality through sequence and chemical space.

ABLE (bottom left): Depicted as a helical bundle binding the drug apixaban, labeled as a "specialist" in binding apixaban. Its binding site is shown as a filled cavity with the drug's structure.
ABLE as a generalist (center): After fragment screening, ABLE evolves to weakly bind various small molecule fragments, shown in a diverse array within the cavity. This transition highlights the exploration of chemical space.
FABLE (top right): Derived from fragment-inspired design, FABLE binds turn-on fluorophores. The binding site is reconfigured to fit fluorophores like Cou485, with their chemical structures displayed.
KABLE (bottom right): Another fragment-inspired evolution turns ABLE into KABLE, a Kemp eliminase. The structure of the substrate (5-nitrobenzisoxazole) is shown, with the binding site adapted for catalysis.
The axes represent "Sequence Space" (vertical) and "Chemical Space" (horizontal), emphasizing how the protein evolves through these dimensions to achieve specialized functions.
This schematic encapsulates the journey of ABLE from a specific binder to a generalist and then into two specialized proteins with distinct functionalities.

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