Reposted by Holger KleinRobert Henke @roberthenke.bsky.social · 23/04/2026I am going to bring my raw 8 bit sounds to Superbooth this year! May8th, 17:00 Seebühne www.superbooth.com/en/events/de... roberthenke.com/concerts/mon... 0212
Reposted by Holger KleinDaniel Drucker @danieljdrucker.bsky.social · 03/02/2026Dissecting the importance of the murine GCGR vs the GLP-1R for the CNS and #weightloss actions of survodutide @MolMetab www.sciencedirect.com/science/arti... 041
Holger Klein @hol9000.bsky.social · 24/01/2026Saturday evening project: replacing the battery of my #vintage #synthesizer #ensoniq VFX-SD from 1989. Battery soldered to the board… now ready for action again. This model was used by bands like #depechemode, #neworder, #front242. 020
Holger Klein @hol9000.bsky.social · 08/01/2026Thanks a lot, I'll have a look into the liposensitive switch paper as well :-) 010
Holger Klein @hol9000.bsky.social · 08/01/2026This prevents the "forever-on" problem of traditional gene therapy, ensuring the treatment is only active when needed and can be instantly stopped if side effects occur. 100
Holger Klein @hol9000.bsky.social · 08/01/2026For the readers outside this field of work: #Riboswitches might offer a way to make #genetherapy safer: They could act as precise "control knobs" for #genetherapy, allowing doctors to turn a therapeutic gene ON or OFF simply by having the patient take a specific, safe pill. 110
Holger Klein @hol9000.bsky.social · 08/01/2026Paper alert, some news on our #syntheticbiology activities. You can find out paper on the TPP #riboswitch activator at pubs.acs.org/doi/10.1021/.... And even better, you can order the compound for free on #boehringer 's #opnMe platform at www.opnme.com/molecules/tp.... #sciencepubs.acs.orgSmall Molecule-Controlled Gene Expression: Design of Drug-like High-Affinity Modulators of a Custom-Made RiboswitchRiboswitches are regulatory RNA structures that modulate gene expression in response to a small molecule. Until now, most efforts to design ligand analogs were motivated by their potential antibiotic ... 121
Holger Klein @hol9000.bsky.social · 05/01/2026#moon through the #clouds yesterday evening. It was cold (-7degrees C) and only had my cellphone with me, would have been a good opportunity to take some more #photos. 100
Holger Klein @hol9000.bsky.social · 24/12/2025I just wish I knew which part is causing problems… I’ll spend another evening on it soon. 300
Holger Klein @hol9000.bsky.social · 30/11/2025Another challenge: the tape drive seems to have some mechanical problems, and on top, I don't have software. As far as I read, it should be possible otherwise to put audio files to tapes and use them... 000
Holger Klein @hol9000.bsky.social · 30/11/2025And this is close enough to the #commodore world, but it is said to be richer in comparison. But since I got it by chance many years back, and never looked into it, not much experience to do more interesting stuff with it. 100
Holger Klein @hol9000.bsky.social · 30/11/2025Upon start, one is greeted by CAOS, the cassette assisted operating system. One can choose BASIC... 100
Holger Klein @hol9000.bsky.social · 30/11/2025More #retrocomputing. Played around again with the #KC85/4 from #robotron, that was collecting dust. Built in the #GDR/#DDR between '84 and '88, it has a #U880 as a CPU. This is an unlicensed clone of the Zilog #Z80, produced by the VEB Mikroelektronik „Karl Marx“. 150
Holger Klein @hol9000.bsky.social · 27/11/2025It has a #mos6509 cpu and 128kb of RAM. The version with built in floppy disks is said to rare. Serial number 2580 :). #retrocomputing 010
Holger Klein @hol9000.bsky.social · 27/11/2025Trying to fix my old #cbm710. A #commodore machine from the early 80s, #BASIC very similar to what I knew from the #c64, had programmed a nice screensaver for it. Unfortunately stopped to work some time ago. First attempt unsuccessful… 2147
Holger Klein @hol9000.bsky.social · 19/09/2025clear #sky tonight - a bit of the #milkyway from the garden just taken on the cellphone #bluesky #photography 050
Holger Klein @hol9000.bsky.social · 18/08/2025#flamingos in #deltadelebre in #catalunya. #nature #photography 0181
Holger Klein @hol9000.bsky.social · 18/08/2025#dragonfly in #deltadelebre in #catalunya. #photography #nature 080
Holger Klein @hol9000.bsky.social · 09/08/2025#photo of full #moon rise in catalunya / #medieranean sea #nikon z6II at 200mm f6.3 1/10sec / 9.8.2025 040
Holger Klein @hol9000.bsky.social · 08/07/2025So happy to have seen #HerbieHancock in #Munich yesterday evening. Great band and great set covering many of my favourite albums, quite a lot of weight on the 70s. One of the big influences on my #music taste. 010
Holger Klein @hol9000.bsky.social · 15/05/2025Happy to share the outcome of one of our #collaborations in the #obesity space - #publication of Jonathan Trujillo Viera et al - check it out: www.sciencedirect.com/science/arti...sciencedirect.comAbundance of a metabolically active subpopulation in dedifferentiated adipocytes inversely correlates with body mass index.The cellular composition and functionality of adipose tissue are key determinants of metabolic diseases associated with adipose tissue dysregulation, … 010
Holger Klein @hol9000.bsky.social · 22/04/2025Some #berlin impressions. Always great to be back and meet old friends and former colleagues. #photography #urban 050
Reposted by Holger KleinNils Weskamp @nilsweskamp.bsky.social · 08/04/2025Are you a passionate drug hunter and an inspirational leader with a background in computational chemistry? So you want to make a difference in cancer research? Then this could be for you: jobs.boehringer-ingelheim.com/job/Vienna-S... #ChemJobs #EuChemJobs #ChemSky #CompChemjobs.boehringer-ingelheim.comScientific Director Computational Chemistry (m/f/d)Scientific Director Computational Chemistry (m/f/d) 0119
Reposted by Holger KleinNils Weskamp @nilsweskamp.bsky.social · 03/03/2025We are searching for an experienced Medicinal Chemist in Biberach, Germany. The position is located in a small, agile team focusing on Animal Health (as part of a larger MedChem department). You might have to listen to my synthesis ideas. 😀 #ChemSky jobs.boehringer-ingelheim.com/job/Biberach...jobs.boehringer-ingelheim.comPrincipal Scientist - Medicinal Chemistry Animal HealthPrincipal Scientist - Medicinal Chemistry Animal Health 144
Holger Klein @hol9000.bsky.social · 18/02/2025Looking for a #datascience / #drugdiscovery #postdoc on the interface between academia and industry? Check this out: ventures.yale.edu/news/applica...ventures.yale.eduApplications Open for Expanded Yale-Boehringer Ingelheim Biomedical Data Science Fellowship Program | Yale Ventures 021
Holger Klein @hol9000.bsky.social · 14/02/2025Pictures taken already three weeks ago, but not unlikely we’ll see something similar this weekend. #iceneedles #frost #photography 0110
Holger Klein @hol9000.bsky.social · 14/02/2025* Real Word Data / Oncology (Vienna/Austria) - jobs.boehringer-ingelheim.com/job/Vienna-P... * Application Landscape Owner/Data&Infrastructure (Vienna/Austria) - jobs.boehringer-ingelheim.com/job/Vienna-A...jobs.boehringer-ingelheim.comPrincipal Scientist Oncology RWD Analysis (m/f/d)Principal Scientist Oncology RWD Analysis (m/f/d) 010
Holger Klein @hol9000.bsky.social · 14/02/2025A few job openings in the CompBio and Digital Sciences Department at Boehringer: * Omics Engineering (Biberach/South of Germany) - jobs.boehringer-ingelheim.com/job/Biberach... * Senior Data Scientist (Biberach/South of Germany) - jobs.boehringer-ingelheim.com/job/Biberach...jobs.boehringer-ingelheim.comSenior / Principal Scientist - Omics EngineeringSenior / Principal Scientist - Omics Engineering 122
Holger Klein @hol9000.bsky.social · 09/02/2025Didn't check the other genes, but TRPM6 is an ion channel involved in Mg homeostasis... I don't get the cat hint yet, though. 110
Holger Klein @hol9000.bsky.social · 06/02/2025Thank you - Digital, Nikon Z6II with a Sigma 100-400mm. Still didn’t set up a mastodon account, will look into this. 000
Holger Klein @hol9000.bsky.social · 03/02/2025Soon we might need antivirus tools in our NGS pipelines :-) www.wired.com/story/malwar... #genomics #ngs #bioinformaticswired.comBiohackers Encoded Malware in a Strand of DNAResearchers planted a working hacker exploit in a physical strand of DNA. 010
Holger Klein @hol9000.bsky.social · 28/01/2025How do people deal with cross posting here? Just wrote up a few thoughts on plasma omics on LinkedIn: www.linkedin.com/posts/holger...linkedin.comHolger Klein on LinkedIn: 💡 Growing Importance of Plasma Omics - And There's More to Come! The UK…💡 Growing Importance of Plasma Omics - And There's More to Come! The UK Biobank plasma omics data have been available for a while (e.g., Sun et al.… 000
Holger Klein @hol9000.bsky.social · 27/01/2025Starting my bluesky existence with at least one recent picture also containing blue sky. Taken with a 200-400mm lens. #moon 140