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Holger Klein

@hol9000.bsky.social
45 followers 93 following 32 posts

Mainly here for #ComputationalBiology (long-term experience in academia, core facilities, small/medium companies and pharma), #Music and #Photography.

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Reposted by Holger Klein
Robert Henke @roberthenke.bsky.social · 23/04/2026
I am going to bring my raw 8 bit sounds to Superbooth this year! May8th, 17:00 Seebühne www.superbooth.com/en/events/de... roberthenke.com/concerts/mon...
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Reposted by Holger Klein
Daniel Drucker @danieljdrucker.bsky.social · 03/02/2026
Dissecting the importance of the murine GCGR vs the GLP-1R for the CNS and #weightloss actions of survodutide @MolMetab www.sciencedirect.com/science/arti...
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Holger Klein @hol9000.bsky.social · 24/01/2026
Saturday evening project: replacing the battery of my #vintage #synthesizer #ensoniq VFX-SD from 1989. Battery soldered to the board… now ready for action again. This model was used by bands like #depechemode, #neworder, #front242.
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Holger Klein @hol9000.bsky.social · 08/01/2026
Paper alert, some news on our #syntheticbiology activities. You can find out paper on the TPP #riboswitch activator at pubs.acs.org/doi/10.1021/.... And even better, you can order the compound for free on #boehringer 's #opnMe platform at www.opnme.com/molecules/tp.... #science
pubs.acs.org
Small Molecule-Controlled Gene Expression: Design of Drug-like High-Affinity Modulators of a Custom-Made Riboswitch
Riboswitches are regulatory RNA structures that modulate gene expression in response to a small molecule. Until now, most efforts to design ligand analogs were motivated by their potential antibiotic ...
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Holger Klein @hol9000.bsky.social · 05/01/2026
#moon through the #clouds yesterday evening. It was cold (-7degrees C) and only had my cellphone with me, would have been a good opportunity to take some more #photos.
Moon through the clouds
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Holger Klein @hol9000.bsky.social · 30/11/2025
More #retrocomputing. Played around again with the #KC85/4 from #robotron, that was collecting dust. Built in the #GDR/#DDR between '84 and '88, it has a #U880 as a CPU. This is an unlicensed clone of the Zilog #Z80, produced by the VEB Mikroelektronik „Karl Marx“.
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Holger Klein @hol9000.bsky.social · 27/11/2025
Trying to fix my old #cbm710. A #commodore machine from the early 80s, #BASIC very similar to what I knew from the #c64, had programmed a nice screensaver for it. Unfortunately stopped to work some time ago. First attempt unsuccessful…
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Holger Klein @hol9000.bsky.social · 19/09/2025
clear #sky tonight - a bit of the #milkyway from the garden just taken on the cellphone #bluesky #photography
Photo from the milky way
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Holger Klein @hol9000.bsky.social · 18/08/2025
#flamingos in #deltadelebre in #catalunya. #nature #photography
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Holger Klein @hol9000.bsky.social · 18/08/2025
#dragonfly in #deltadelebre in #catalunya. #photography #nature
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Holger Klein @hol9000.bsky.social · 09/08/2025
#photo of full #moon rise in catalunya / #medieranean sea #nikon z6II at 200mm f6.3 1/10sec / 9.8.2025
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Holger Klein @hol9000.bsky.social · 08/07/2025
So happy to have seen #HerbieHancock in #Munich yesterday evening. Great band and great set covering many of my favourite albums, quite a lot of weight on the 70s. One of the big influences on my #music taste.
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Holger Klein @hol9000.bsky.social · 15/05/2025
Happy to share the outcome of one of our #collaborations in the #obesity space - #publication of Jonathan Trujillo Viera et al - check it out: www.sciencedirect.com/science/arti...
sciencedirect.com
Abundance of a metabolically active subpopulation in dedifferentiated adipocytes inversely correlates with body mass index.
The cellular composition and functionality of adipose tissue are key determinants of metabolic diseases associated with adipose tissue dysregulation, …
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Holger Klein @hol9000.bsky.social · 22/04/2025
Some #berlin impressions. Always great to be back and meet old friends and former colleagues. #photography #urban
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Reposted by Holger Klein
Nils Weskamp @nilsweskamp.bsky.social · 08/04/2025
Are you a passionate drug hunter and an inspirational leader with a background in computational chemistry? So you want to make a difference in cancer research? Then this could be for you: jobs.boehringer-ingelheim.com/job/Vienna-S... #ChemJobs #EuChemJobs #ChemSky #CompChem
jobs.boehringer-ingelheim.com
Scientific Director Computational Chemistry (m/f/d)
Scientific Director Computational Chemistry (m/f/d)
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Reposted by Holger Klein
Nils Weskamp @nilsweskamp.bsky.social · 03/03/2025
We are searching for an experienced Medicinal Chemist in Biberach, Germany. The position is located in a small, agile team focusing on Animal Health (as part of a larger MedChem department). You might have to listen to my synthesis ideas. 😀 #ChemSky jobs.boehringer-ingelheim.com/job/Biberach...
jobs.boehringer-ingelheim.com
Principal Scientist - Medicinal Chemistry Animal Health
Principal Scientist - Medicinal Chemistry Animal Health
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Holger Klein @hol9000.bsky.social · 18/02/2025
Looking for a #datascience / #drugdiscovery #postdoc on the interface between academia and industry? Check this out: ventures.yale.edu/news/applica...
ventures.yale.edu
Applications Open for Expanded Yale-Boehringer Ingelheim Biomedical Data Science Fellowship Program | Yale Ventures
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Holger Klein @hol9000.bsky.social · 14/02/2025
Pictures taken already three weeks ago, but not unlikely we’ll see something similar this weekend. #iceneedles #frost #photography
Ice needles on twigs
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Holger Klein @hol9000.bsky.social · 14/02/2025
A few job openings in the CompBio and Digital Sciences Department at Boehringer: * Omics Engineering (Biberach/South of Germany) - jobs.boehringer-ingelheim.com/job/Biberach... * Senior Data Scientist (Biberach/South of Germany) - jobs.boehringer-ingelheim.com/job/Biberach...
jobs.boehringer-ingelheim.com
Senior / Principal Scientist - Omics Engineering
Senior / Principal Scientist - Omics Engineering
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Holger Klein @hol9000.bsky.social · 08/02/2025
#niewiederistjetzt #biberach
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Holger Klein @hol9000.bsky.social · 03/02/2025
Soon we might need antivirus tools in our NGS pipelines :-) www.wired.com/story/malwar... #genomics #ngs #bioinformatics
wired.com
Biohackers Encoded Malware in a Strand of DNA
Researchers planted a working hacker exploit in a physical strand of DNA.
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Holger Klein @hol9000.bsky.social · 28/01/2025
How do people deal with cross posting here? Just wrote up a few thoughts on plasma omics on LinkedIn: www.linkedin.com/posts/holger...
linkedin.com
Holger Klein on LinkedIn: 💡 Growing Importance of Plasma Omics - And There's More to Come! The UK…
💡 Growing Importance of Plasma Omics - And There's More to Come! The UK Biobank plasma omics data have been available for a while (e.g., Sun et al.…
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Holger Klein @hol9000.bsky.social · 27/01/2025
Starting my bluesky existence with at least one recent picture also containing blue sky. Taken with a 200-400mm lens. #moon
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