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Reposted by Quentin Herail

Constantin Anoyatis @canopele.bsky.social · 08/10/2025

Proud of our new study out in @cp-cellreports.bsky.social! Using E. coli lacking all 8 endopeptidases, we provide direct evidence that peptidoglycan expansion during elongation requires ED-mediated insertion of one glycan strand at a time. This can be performed by MepS, MepM, MepH and PBP7 #microsky

sciencedirect.com

Role of endopeptidases in lateral cell wall expansion in Escherichia coli

Peptidoglycan, the major constituent of bacterial cell walls, is a giant macromolecule made of glycan strands cross-linked by short peptides, which pr…

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Reposted by Quentin Herail

Hugonnet Lab @jeh-lab.bsky.social · 25/07/2025

Thrilled to announce our new paper with M. Ethève-Quelquejeu's lab @upcite.bsky.social published @chemistryeurope.bsky.social! We report on the synthesis, and testing by HRMS, of new β-lactam prodrugs, a proof of concept for designing drugs targetting specifically β-lactamase-producing pathogens.

doi.org

Optimization of Prodrug Activation by Enzymatic Cleavage of the β‐lactam Ring of Carbapenems

We report synthetic routes that yield prodrugs consisting of two carbapenems connected by benzyl carbonate linkers. A mass spectrometry assay was elaborated to monitor, in a single kinetic experiment...

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Reposted by Quentin Herail

Hugonnet Lab @jeh-lab.bsky.social · 16/04/2025

Check out our study on combination of amox, imi and relebactam to treat M. abscessus! Our findings constitute the basis for a clinical consideration of this treatment. This could be consequential for treating infections in cystic fibrosis patients @vaincrelamuco.bsky.social doi.org/10.1093/jac/...

doi.org

In vitro, intracellular and in vivo synergy between amoxicillin, imipenem and relebactam against Mycobacterium abscessus

AbstractObjectives. Mycobacterium abscessus is the most frequent of the rapidly growing mycobacteria responsible for lung infections in patients suffering

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