iiinova — where your digital self keeps evolving

Hashim @hashimreza.bsky.social · 16/08/2026

Glad to be a part of this work where our study suggests a non-canonical role of Mcm7, a replication protein, in the maintenance of microtubule and nucleolar homeostasis. Kudos to @srijanadutta.bsky.social for leading the study.

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Reposted by Hashim

Bungo Akiyoshi @bungoakiyoshi.bsky.social · 15/08/2026

New preprint from the lab! One reason why I chose work on trypanosomes is to address this question "How do they determine kinetochore position without a centromeric histone H3 variant, CENP-A/CenH3?" After working on this question for 16 years, we finally got a clue

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Hashim @hashimreza.bsky.social · 16/07/2026

Thank you, Jana. I would love to collaborate. Let's discuss soon.

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Hashim @hashimreza.bsky.social · 16/07/2026

Congratulations Jana! Looking forward to exciting science from your lab.

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Hashim @hashimreza.bsky.social · 09/06/2026

Congratulations to both of you!!

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Hashim @hashimreza.bsky.social · 27/11/2025

Congratulations Jana 👏🥳

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Reposted by Hashim

Gautam Dey @gautamdey.bsky.social · 27/11/2025

So proud to watch Jana turn a side quest into an entire research programme. Couldn’t imagine a more well-deserved outcome. 😍 The mighty yeast reveals what we believe are general principles of centromere evolution! Behind the curtain: communities.springernature.com/posts/counti... #MEvoSky 🧪🌎

communities.springernature.com

Counting Chromosomes: The Simple Idea That Unlocked the Rules Behind Centromere Evolution

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Hashim @hashimreza.bsky.social · 01/07/2025

Interested in contributing? Please submit an abstract here: {JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols}

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Hashim @hashimreza.bsky.social · 01/07/2025

As a Guest Editor for @JoVEJournal, I am organizing a Methods Collection titled “Advanced Methods to Study Pathogenic Features of Morphological Transitions and Ploidy Changes in Fungal Pathogens.”

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Reposted by Hashim

Gautam Dey @gautamdey.bsky.social · 20/06/2025

Elegant work by my colleagues Jenna & Anna Erzberger: information transfer across cellular compartment boundaries can be encoded in the distribution of surface-embedded particles (integrins, GPCRs…) True for the nuclear envelope too - we provide data on NPC-microtubule interactions in Ichthyosporea

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Hashim @hashimreza.bsky.social · 03/04/2025

10. Huge shoutout to all the scientists Arshad Desai, Elmar Schiebel, @gautamdey.bsky.social, @suebiggins.bsky.social, Guislene Pereira, Joe Heitman, Sunil Laxman, @syncellbiolab.bsky.social, and Uttam Surana for their valuable inputs and engaging discussions.

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Hashim @hashimreza.bsky.social · 03/04/2025

9. This work was possible with amazing colleagues & collaborators Rashi Aggarwal, Jigyasa Verma, Nitesh Podh, Ratul Chowdhury, & Gunjan Mehta, and discussions with both past and present lab members at Molecular Mycology Lab, and funding support from DBTIndia, ANRF, and JNCASR.

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Hashim @hashimreza.bsky.social · 03/04/2025

7. We show that Atg11 facilitates dynamic instability of astral microtubules (aMTs) and prevents catastrophe frequency, which is complemented by stabilized Clb4 levels with loss of Atg11. Big thanks to @minhajs.bsky.social for discussions related to experimentation and analyses for aMT instability.

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Hashim @hashimreza.bsky.social · 03/04/2025

6. Consequently, we observed FEAR-defective phenotypes: delayed Cdc14 release, spindle buckling, and spindle positioning and alignment defects which are Kar9-dependent.

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Hashim @hashimreza.bsky.social · 03/04/2025

5. Increased mono-oriented kinetochores, sensed by the Aurora kinase BIpl1 activate the spindle assembly checkpoint (SAC), stabilizing securin (Pds1), and thus delaying cell cycle progression in the absence of Atg11.

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Hashim @hashimreza.bsky.social · 03/04/2025

To our surprise, we identified a dynamic, microtubule-dependent, pool of Atg11 at the SPBs, ‘a second home’ in addition to its cytosolic pool.

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Hashim @hashimreza.bsky.social · 03/04/2025

4. Are there constant pools of Atg11 at the SPBs required for MT regulation? In collaboration with Gunjan Mehta@IIT H, we utilized single-molecule tracking (SMT) to answer this.

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Hashim @hashimreza.bsky.social · 03/04/2025

Remarkably, Atg11 in addition to its canonical localization, also localizes at the interface of vacuole-nucleus and displays a transient association with SPBs in a cell cycle-dependent manner.

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Hashim @hashimreza.bsky.social · 03/04/2025

3. How does a pre-autophagosome (PAS) protein Atg11 contribute to microtubule-dependent processes? The interaction network hinted towards a physical association of Atg11 with Spc72, a spindle pole body (SPB) protein.

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Hashim @hashimreza.bsky.social · 03/04/2025

2. We found that loss-of-function of Atg11 displays increased sensitivity to microtubule poison, thiabendazole and higher temperature (37°C), hinting towards a role of Atg11 in the microtubule-dependent process.

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Hashim @hashimreza.bsky.social · 03/04/2025

1. This work started as a collaborative project between @kaustuvsanyal.bsky.social and Ravi Manjithaya labs at JNCASR. We created an interaction network of autophagy and cell cycle proteins. Intrigued by the interactions, we asked if autophagy protein(s) have any role in mitosis.

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