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Harry Wilders @harrywilders.bsky.social · 11/01/2025

Excited to see this out in Nature Communications. A great platform to profile reactive fragments against the human proteome (and beyond), quickly and accurately. #ChemBio #Chemsky

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Reposted by Harry Wilders

Adam Nelson @adam-s-nelson.bsky.social · 28/12/2024

Interested in a PhD combining high-throughput synthesis, structural and cell biology to understand kinases? Deadline to apply for a project with Richard Bayliss, Helen Matthews and me: January 6th! www.findaphd.com/phds/project...

findaphd.com

Probing covalent mechanisms of regulation and inhibition in mitotic kinases at University of Leeds on FindAPhD.com

PhD Project - Probing covalent mechanisms of regulation and inhibition in mitotic kinases at University of Leeds, listed on FindAPhD.com

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Harry Wilders @harrywilders.bsky.social · 11/12/2024

I am happy to share that our recent work has been published in Angewandte Chemie. We demonstrate how ‘direct-to-biology’ screening can accelerate optimisation campaigns, yielding potent covalent and non-covalent inhibitors from reactive fragment hits. onlinelibrary.wiley.com/doi/full/10....

onlinelibrary.wiley.com

Expedited SARS‐CoV‐2 Main Protease Inhibitor Discovery through Modular ‘Direct‐to‐Biology’ Screening

Direct-to-biology workflows promise to accelerate hit optimisation for drug discovery. Here, we describe a direct-to-biology method for the efficient synthesis and screening of cysteine-reactive frag...

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