Nature Metabolism, Published online: 02 July 2025; doi:10.1038/s42255-025-01318-6High-resolution multi-omic profiling indicates widespread gut dysbiosis in individuals with MASLD, also affecting the virome, and reveals microbial signatures that can classify MASLD and its subtypes.

Nature Metabolism, Published online: 02 July 2025; doi:10.1038/s42255-025-01300-2The gut microbiome is pivotal to the development of liver diseases in multifaceted ways. A recent study uses a multi-omics, multi-kingdom approach to analyse the gut dysbiosis in metabolic dysfunction-associated steatotic liver disease, highlighting a substantial role for oral-typical microorganisms and their associated metabolites.

Hanseul Kim and Long H. Nguyen, MD, MS discuss their new paper, “Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease.”