Phylogenetic conservation scores have long been used to identify selection targets in the genome. With machine learning, they take a new form and will likely grow in popularity. @apragsdale.bsky.social and I investigate their relationship with mutation rates
www.biorxiv.org/content/10.6...
biorxiv.org
Strong correlations between mutation rates and selective constraint in the human genome?
The 21st century has seen repeated challenges to the premise that de novo mutations occur independently from their fitness effects. So far, these attempts have been dismissed as technical artifacts, r...
