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Gutmann Lab

@gutmannlab.bsky.social
1.9K followers 623 following 122 posts

We study the genetic, cellular, and molecular causes for brain tumors and neurodevelopmental disabilities in children and adults with Neurofibromatosis (NF). To learn more: gutmannlab.wustl.edu and nfcenter.wustl.edu

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Gutmann Lab @gutmannlab.bsky.social · 30/09/2026
A merienda with a side of culture! 🌎❤️ Our Hispanic lab members brought foods from their home countries and shared more about their cultures and the spirit of Hispanic Heritage Month. A delicious way to learn, celebrate, and share together! 🎉
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Gutmann Lab @gutmannlab.bsky.social · 18/09/2026
With September being the month with most birthdays worldwide, it’s no surprise the Gutmann Lab is celebrating three: Vaishali, Shin, and Anthony! Wishing our September babies a very happy birthday! 🥳🎂
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Gutmann Lab @gutmannlab.bsky.social · 01/09/2026
Great science in action! ✨ Corina, Vaishali, and Enquan presented their posters at the Gilbert Family Foundation annual meeting this week. We love sharing our work, exchanging ideas, and building strong connections across the amazing NF community! #GFF #NF1 #SciComm
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Gutmann Lab @gutmannlab.bsky.social · 21/08/2026
Happy birthday, Dr. Gutmann! 🎂🎉 We’re grateful for all the mentorship, support, and encouragement you bring to the lab every day. Thank you for making the Gutmann Lab a place where science, learning, and people can thrive! 💙💛 #HappyBirthday
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Gutmann Lab @gutmannlab.bsky.social · 31/07/2026
Today, Megan presented her poster at the Siteman Cancer Center through the Leah Menshouse Springer Summer Program! During the summer she worked with her mentor, Jit, to investigate how NF1 shapes gut immune cell populations in mice. We're so proud of everything she accomplished!
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Gutmann Lab @gutmannlab.bsky.social · 29/07/2026
New style for the lab! We debuted our fresh Gutmann Lab tees at last weekend's summer picnic. Great weather, great food, and even better company made for a fantastic day together! ☀️👕
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Gutmann Lab @gutmannlab.bsky.social · 20/07/2026
This weekend we celebrated our 4th NF Family Day!🎉🌞Between St. Louis BBQ, crafts and so many fun games, Corina shared how our lab is pioneering new NF1 research. It's always inspiring to answer questions and connect directly with the incredible families driving our research. See you next year! #NF1
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Gutmann Lab @gutmannlab.bsky.social · 14/07/2026
Another lab meeting highlight! 🌴💘 Vanesa introduced the latest couple in the villa: neurons and tumors. Their relationship is full of chemistry, attraction, and... a whole lot of red flags. 🚩💔 Thankfully we are here to work things out!
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Gutmann Lab @gutmannlab.bsky.social · 29/06/2026
STL summer heat is no joke, so we paused the science for an ice cream break! 🍦 But the peace didn't last long and our gloves came off with a few rounds of Uno. Turns out we take "Draw 4" very seriously in this lab. Feel free to join us next time! #Lablife
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Gutmann Lab @gutmannlab.bsky.social · 11/05/2026
Check out the latest Genes & Development! 🚨 Enquan introduces PANCOS: a breakthrough PA-human cerebral assembloids that recapitulate tumor pathology and can be used to discover growth dependencies. Intrigued by our animated cover? Dive into the full story here: genesdev.cshlp.org/content/40/9...
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WashU Medicine Neurology @washuneurology.bsky.social · 23/04/2026
David Gutmann, MD, PhD, received the Hans-Dietrich Hermann Lectureship in honor of his outstanding achievements in translational neuro-oncology from the Universitätsklinikum Hamburg-Eppendorf in Germany. Congratulations!
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Gutmann Lab @gutmannlab.bsky.social · 22/04/2026
We are so proud of Vanesa for winning the DBBS postbac 3-minute elevator pitch! 🎉 She was handsomely rewarded with delicious donuts. Her work in the lab explores how cancer cells communicate with neurons in vitro, revealing how tumors may recruit neural activity to fuel growth. #YouGotThis👏
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Gutmann Lab @gutmannlab.bsky.social · 16/04/2026
We are celebrating early Earth Day by recognizing Stephanie and Jenny! 🌎💚 Their leadership helped our lab earn Green Lab certification, and today they were honored at the Green Carpet Awards by the Green Labs Initiative. We are very grateful for their commitment to a more sustainable science! 🌱
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Gutmann Lab @gutmannlab.bsky.social · 18/03/2026
Happy St. Patrick's day everyone! 🍀 With green fits and a whole lot of festive science, we’re celebrating curiosity, teamwork, and a little extra magic in this lucky day. 🌈
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Gutmann Lab @gutmannlab.bsky.social · 12/03/2026
Lab meetings are the best place to polish your presentation skills and let your creativity shine! This week Chloe and Elvedina did a fantastic job explaining their projects and leading discussions. They have not been long in the lab but they are improving at lightspeed. Truly the best!
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DMM Journal @dmmjournal.bsky.social · 03/03/2026
In their Perspective, Lori Forster and @gutmannlab.bsky.social apply the nested ecosystems concept to #glioma, clarify how diverse risk factors shape CNS oncobiology, and highlight new opportunities for targeted disease‑mitigation strategies. Read: doi.org/10.1242/dmm....
Diagram depicting brain tumors as nested ecosystems. Four concentric bowls represent cellular, tissue, body, and environmental levels. A second panel lists three features of nested ecosystems: diversity with spatial and temporal variation, intersectional communication within and between levels, and dynamic adaptation to external influences.
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Gutmann Lab @gutmannlab.bsky.social · 11/02/2026
We kicked off the month with a double birthday celebration! 🎉 Lori and Chloe were treated to a homemade vegan, gluten-free cake on their request (about 95% chocolate 😉). Taking time to celebrate together the good moments matters now more than ever.
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Gutmann Lab @gutmannlab.bsky.social · 17/12/2025
Happy Hanukkah from the Gutmann lab!! 🕎 We are celebrating the 3rd day/4rd night with some delicious sufganiyot. May the lights of Hanukkah bring everyone warmth and joy in this special season.
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Gutmann Lab @gutmannlab.bsky.social · 17/12/2025
Happy Hanukkah from the Gutmann lab!! 🕎 We are celebrating the 3rd day/4rd night with some delicious sufganiyot. May the lights of Hanukkah bring everyone warmth and joy in this season.
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Gutmann Lab @gutmannlab.bsky.social · 09/12/2025
We’re grateful to Penny’s Flight Foundation and Kate Doerge for featuring our lab's research as part of their mission to raise awareness and critical funds to #ENDNF. This clip is just a glimpse! Go watch the full video and learn more about their amazing work on the Penny’s Flight YouTube channel.
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Gutmann Lab @gutmannlab.bsky.social · 04/12/2025
Join us in celebrating Dr. Gutmann as the NFX 2025 Strength & Honor honoree for his dedication to NF research and mentorship! We also recognize Harper Grace Durham, the Head & Heart honoree, whose strength and advocacy inspire the entire NF community. Watch their shared story in the video below:
youtube.com
2025 - Head and Heart honoree, Dr. David Gutmann, and Strength and Honor honoree, Harper Grace
YouTube video by NFX Detroit
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Gutmann Lab @gutmannlab.bsky.social · 03/12/2025
Celebrations are in full swing in the Gutmann Lab! 🎉 Yesterday’s Labsgiving and white elephant were a great way to appreciate the wonderful people who make this science family special. Wishing everyone a happy holiday season! 🎁❄️
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Gutmann Lab @gutmannlab.bsky.social · 01/11/2025
Wishing you a boo-tiful Halloween from the lab! 🧪🎃 May your experiments work and your candy be plentiful. 👻
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Gutmann Lab @gutmannlab.bsky.social · 27/10/2025
Last Friday,we welcomed our friends from Forward Strides 4NF,an amazing family-founded charity that brings awareness and support to the NF center with their fundraising opportunities,like the fun annual family walk you shouldn't miss! We are grateful for their endorsement and opportunity to connect💙
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Pearl Freier @pearlf.bsky.social · 11/02/2025
The FDA approved a new cancer drug by SpringWorks Therapeutics— MEK inhibitor mirdametinib (brand name Gomekli) for adult & pediatric patients (> age 2) w/ neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PN) not amenable to complete resection www.cancernetwork.com/view/fda-app...
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Gutmann Lab @gutmannlab.bsky.social · 06/10/2025
Excited to share our latest work in Neuro-Oncology Advances! 🥳 After comparing several potential therapies, we identified lamotrigine as a promising therapy for NF1 optic glioma, showing both tumor reduction and vision protection. Check out the work of our great team!
academic.oup.com
Head-to-head preclinical treatment design prioritizes promising therapies for neurofibromatosis type 1 optic glioma clinical translation
AbstractBackground. Authenticated preclinical brain tumor models provide unprecedented opportunities to evaluate next-generation treatments. However, some
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Gutmann Lab @gutmannlab.bsky.social · 03/09/2025
Exciting news! Our new paper is out in Neuron! We discovered how neurons drive brain tumor growth through aberrant glutamate–tyrosine kinase signaling, uncovering novel mechanisms that shape tumor progression. Grateful to our team & collaborators for making this breakthrough possible! 🧠✨
cell.com
Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth
Anastasaki and colleagues establish a previously unknown glutamate growth dependency in pediatric low-grade brain tumors (gliomas). Glioma cells hijack normal neuron-glial molecular circuits present d...
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Gutmann Lab @gutmannlab.bsky.social · 04/08/2025
We are so proud of Rasha and Rui's new paper! Their single cell reveals hidden diversity in CD8+ exhausted T cells across cancers, shedding light on why patients respond differently to immunotherapy and bringing us closer to more effective therapies. Don’t miss this exciting advance from our team!
tandfonline.com
Pan-cancer single cell transcriptomic clustering reveals heterogeneous CD8+ exhausted T cell populations with different immune checkpoint inhibitor responses
In most cancers, T lymphocytes comprise an essential cellular component of the non-neoplastic microenvironment, where they have the capacity to both suppress and support tumor growth. One specializ...
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Gutmann Lab @gutmannlab.bsky.social · 01/08/2025
We were thrilled to welcome Girl Scout Troop 222 to the lab this week! They explored science hands-on and got a glimpse of the work we do. Grateful for their curios minds and amazing energy—let’s keep inspiring the next generation of scientists! 🔬💫 #GirlsInSTEM #Troop222
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Gutmann Lab @gutmannlab.bsky.social · 22/07/2025
This past weekend we celebrated the 3rd Annual NF Family Day - a special time to honor our patients and families, build community, and have fun! From shaved ice and giant slides to visits from the St. Louis Fire and Police Department, we’re grateful for the support and another year moving forward.
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Gutmann Lab @gutmannlab.bsky.social · 16/07/2025
Today we celebrated two incredible members of the Gutmann lab. We'll miss Alex’s cooking tips and Talia’s humor, but we’re excited for all that lies ahead on their next adventures!
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Gutmann Lab @gutmannlab.bsky.social · 20/06/2025
Another year, another cherised lab photo! We are excited to see some colleagues embark on new journeys and we warmly welcome our newest members. What never changes is our commitment to a happy and collaborative research environment. #Researchteam #lablife
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Gutmann Lab @gutmannlab.bsky.social · 04/06/2025
This week we have said, "See you later" (never goodbye) to an incredible lab member! Chloe has brought joy and amazing work to the lab since her undergrad for more than 4 years. We wish her the best in NYC and her journey to med school.
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Gutmann Lab @gutmannlab.bsky.social · 12/05/2025
We are so happy to have our friends from Penny's Flight Foundation visit last week! It was wonderful sharing the exciting NF1 research currently happening in the lab. We're so grateful for their dedication to raising NF awareness, supporting patients, and championing research. #nf1 🦋
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Gutmann Lab @gutmannlab.bsky.social · 22/04/2025
Another celebration for the Gutmann Lab! Today, one of our newest undergrads, Paulina, makes her debut into the 20s. We are excited to have her for the summer and support her on her scientific journey next year. Happy Birthday Paulina! 🎉
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Gutmann Lab @gutmannlab.bsky.social · 12/04/2025
Today, we celebrate the journey of two amazing trainees in the lab. They have great things coming into their future, and we are equally sad and proud to see them go. Wherever their paths may take them, the Gutmann lab will always be their home. Good luck, Laura and Xuanwei!
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Gutmann Lab @gutmannlab.bsky.social · 09/04/2025
The Gutmann Lab celebrates Giving Day at WashU Medical Campus! In these hard times, our gratitude and donations are more important than ever. A community that supports and helps each other can handle anything that comes their way. #givingday
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DSP💙#🟦✡️ @drawstickpeople.bsky.social · 06/04/2025
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Gutmann Lab @gutmannlab.bsky.social · 27/03/2025
Gilbert Family Foundation for science. #NF1.
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Gutmann Lab @gutmannlab.bsky.social · 27/03/2025
I'm glad to be back in my hometown. Detroit. Michigan. Cliff Bells for jazz.
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Gutmann Lab @gutmannlab.bsky.social · 26/03/2025
True pioneers. Well deserved.
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Katy Montgomerie 🦗 @katymontgomerie.com · 20/03/2025
Tesla has recalled... every single Cybertruck. Every one they've ever sold. For a hardware issue www.carscoops.com/2025/03/tesl...
carscoops.com
Tesla Recalls Every Single Cybertruck Over Stainless Steel Trims Falling Off | Carscoops
151 Cybertruck owners filed warranty claims after noticing the roof trim panel above the windows was coming loose
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Gutmann Lab @gutmannlab.bsky.social · 17/03/2025
👋
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Gutmann Lab @gutmannlab.bsky.social · 16/03/2025
Celebrating with #Lars #Danielsson on the stereo!
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Gutmann Lab @gutmannlab.bsky.social · 16/03/2025
Who's got it better than us??? #BigTen champions!!!
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Gutmann Lab @gutmannlab.bsky.social · 15/03/2025
What an ending. 81-80. Wow! www.espn.com/mens-college... via @ESPN App espn.com/app
espn.com
Michigan 81-80 Maryland (Mar 15, 2025) Final Score - ESPN
Game summary of the Michigan Wolverines vs. Maryland Terrapins NCAAM game, final score 81-80, from March 15, 2025 on ESPN.
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Gutmann Lab @gutmannlab.bsky.social · 14/03/2025
Birthday celebrations 🎂 and a sad goodbye. Yeah to Hallie Youker and Desiree Zanetti-Alepuz and thank you Dahlia Qi.
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Gutmann Lab @gutmannlab.bsky.social · 14/03/2025
Happy Pi Day from @gutmannlab.bsky.social.
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Gutmann Lab @gutmannlab.bsky.social · 10/03/2025
Point well taken. The work continues as we seek to understand the impact of these manipulations on the intestinal microbiota and brain tumors.
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Gutmann Lab @gutmannlab.bsky.social · 10/03/2025
Most certainly. pubmed.ncbi.nlm.nih.gov/39868555/
pubmed.ncbi.nlm.nih.gov
Intestinal Bacteroides drives glioma progression by regulating CD8+ T cell tumor infiltration - PubMed
Taken together, these findings establish, for the first time, a mechanistic relationship between Bacteroides in the intestinal microbiome and NF1-LGG pathobiology, suggesting both future predictive ri...
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