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Guillaume Bourque

@guilbourque.bsky.social
654 followers 90 following 45 posts

Prof in Human Genetics at McGill, Director of Bioinformatics at the McGill Genome Center and Director of @C3Genomics computationalgenomics.ca/BourqueLab

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Guillaume Bourque @guilbourque.bsky.social · 05/06/2026
Indeed! The future is here :)
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BF Francis Ouellette @bffo.bsky.social · 28/04/2026
From @c3genomics.bsky.social, the #Canadian Centre for #Computational #Genomics | Inside #GenPipes: Exploring C3G's Software Solution for Life Science Research | #CoreFacility #OpenScience #Bioinformatics #Education 🧬 🖥️ 🧪 ⬇️ computationalgenomics.ca/inside-genpi...
computationalgenomics.ca
Inside GenPipes: Exploring C3G's Software Solution for Life Science Research - Canadian Centre for Computational Genomics
Take a closer look at one of C3G’s software solutions; its purpose, its strengths, its newest features, and how it continues to support the life science community.
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Guillaume Bourque @guilbourque.bsky.social · 06/03/2026
Exciting to see this out! Please take a look and let us know what you think about our new tool for STR genotyping.
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Cedric Feschotte @cedricfeschotte.bsky.social · 22/01/2026
Crushed to hear of Mark Batzer’s passing. He was the Boyd Professor at Louisiana State University. His influential research revealed how mobile elements shape the genomes of humans & other mammals. Mark’s personality, generosity & positivity were larger than life. He lifted everyone up. HUGE loss 💔
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Guillaume Bourque @guilbourque.bsky.social · 26/12/2025
Nice Christmas gift to see it in print!
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Guillaume Bourque @guilbourque.bsky.social · 12/12/2025
Exciting new conference!
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Guillaume Bourque @guilbourque.bsky.social · 04/12/2025
Congrats Manvendra, well deserved!
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Global Alliance for Genomics and Health @ga4gh.org · 01/12/2025
GA4GH April Connect 2026 registration and session proposal submissions are now open! The meeting will take place from 14 to 17 April 2026 in Montreal, Canada. We invite the GA4GH community to submit session proposals by 30 January. Learn more: broadinstitute.swoogo.com/connect26/10...
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Guillaume Bourque @guilbourque.bsky.social · 07/11/2025
Exciting! Glad to see the Gold Cohort starting to get used for new discoveries!
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Elena Kuzmin @elena-kuzmin.bsky.social · 17/10/2025
Excited to share our preprint on the “Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast Cancer” led by @lynnkaram.bsky.social! www.biorxiv.org/content/10.1...
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Guillaume Bourque @guilbourque.bsky.social · 11/10/2025
Such a great @ga4gh.org meeting in Uppsala this past week. Genomics, with the help of GA4GH standards and policies, is really moving into the Age of Implementation globally!
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Guillaume Bourque @guilbourque.bsky.social · 10/10/2025
I was also very impressive by the progress over the last year. GA4GH is really moving into the Age of Implementation!
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Guillaume Bourque @guilbourque.bsky.social · 10/10/2025
If you’re planning to be at ASHG, you should go see the poster ⬇️
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Guillaume Bourque @guilbourque.bsky.social · 10/10/2025
Wow, great summary!
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Yuxin Zhou @yuxinzhou.bsky.social · 09/10/2025
Thanks for sharing our work, @guilbourque.bsky.social! This work will also be presented at the #ASHG2025 conference on Wednesday, October 15th, in Boston!! My poster can be found at Board 1100W at the Thomas M. Menino Convention Center. Come and talk to me 🧬!!
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Guillaume Bourque @guilbourque.bsky.social · 09/10/2025
We did our best to match the age of the parents at conception and this is only measuring lengths in the child. Moreover, given that the dads are older than mom, if anything we are under-estimating the difference (since older should mean shorter).
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Guillaume Bourque @guilbourque.bsky.social · 09/10/2025
This suggest that telomere maintenance in sperm is more robust than in oocytes and impacts the inherited telomeres. Full paper is below. Curious to know what you think as this is a new area for us! www.biorxiv.org/content/10.1...
biorxiv.org
Long-read sequencing reveals telomere inheritance patterns from human trios
Telomeres are essential for maintaining genomic integrity and are associated with cellular aging and disease, yet the factors influencing their inheritance across generations remain poorly understood....
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Guillaume Bourque @guilbourque.bsky.social · 09/10/2025
The most interesting finding was that in the child, paternally transmitted alleles were significantly longer than age-matched maternal ones (Δmean = 409 bp), particularly when from older parents (Δmean = 698 bp, p = 8.9e-05).
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Guillaume Bourque @guilbourque.bsky.social · 09/10/2025
It got really interesting when we started to do allelic tracing since we had trio data. Amazing to be able to do it by eye in some cases and then @davidlougheed.bsky.social helped us build a tool called TeloScore to apply it to all the families we had.
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Guillaume Bourque @guilbourque.bsky.social · 09/10/2025
We were able to confirm that different chromosome arms have different length distribution, consistent with what was reported in Karimian et al 2024. We also observed the expected age-related length decrease.
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Guillaume Bourque @guilbourque.bsky.social · 09/10/2025
🚨 New paper alert on telomeres! 🚨 Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
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Guillaume Bourque @guilbourque.bsky.social · 27/09/2025
So inspiring to run with Darryl Fox to support Terry’s dream and the @marathonofhope.bsky.social
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John Greally @greally.bsky.social · 18/08/2025
Looks like my book is available for pre-order: a.co/d/cTKIwBN #EpigeneticsBook
a.co
Amazon.com
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Guillaume Bourque @guilbourque.bsky.social · 17/08/2025
Dear @moriartylab.bsky.social, thanks for sharing your story! It was great to work with you at the beginning of the pandemic. I’m so impressed by how much you were able to do since then! You have always been truly committed to the cause. Please take care of yourself, it all starts with that!
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Guillaume Bourque @guilbourque.bsky.social · 11/08/2025
Excited for the start of the Croucher Retrotransposons meeting organized by Danny Leung in Hong Kong. First speaker, the King of Krabs! projects.croucher.org.hk/advanced-stu...
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Guillaume Bourque @guilbourque.bsky.social · 30/07/2025
The issue that jumped at us in the current annotation of young LTR subfamilies in human, is that there was lot of variability in divergence rate (sometimes bimodal). That's what we tried to improve.
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Guillaume Bourque @guilbourque.bsky.social · 23/07/2025
We don’t claim to do it perfectly either… Just think it’s important to highlight the annotation problem and show that we have new tools (eg MPRA) to improve things.
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Guillaume Bourque @guilbourque.bsky.social · 21/07/2025
Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...
science.org
A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage
A phylogenetic approach reveals cryptic LTR subfamilies and functional insights at nucleotide resolution in primates.
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Nadav Ahituv @nadavahituv.bsky.social · 01/07/2025
Lentivirus massively parallel reporter assays integrate & enrich for specific sequences in the genome. We utilize this to test their epigenetic modifications & open chromatin alongside their regulatory activity. Amazing work by Zicong Zhang, Fumitaka Inoue & others. www.biorxiv.org/content/10.1...
biorxiv.org
Simultaneous epigenomic profiling and regulatory activity measurement using e2MPRA
Cis-regulatory elements (CREs) have a major effect on phenotypes including disease. They are identified in a genome-wide manner by analyzing the binding of transcription factors (TFs), various co-fact...
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Adam Phillippy @aphillippy.bsky.social · 12/05/2025
The human pangenome continues to grow and improve! Release 2 is here! Click through for the details, but this is a pretty amazing dataset including not just the phased assemblies, but PacBio HiFi, ONT Ultralong, Dovetail/Illumina Hi-C, PacBio Kinnex, and Illumina WGS for all samples
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Genome Canada @genomecanada.ca · 25/04/2025
Canada’s genomics community is rising to the challenge. ➡️ We’re sequencing 100K human genomes in 4 years to give researchers and innovators the data they need to transform health care. Learn how the diversity of the dataset we build will set Canada apart as a global leader in #PrecisionHealth.
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Jonathan Göke @jonathangoeke.bsky.social · 14/04/2025
Excellent opportunity for PI positions at the Genome Institute of Singapore! Outstanding facilities, latest genomic technologies, strong and stable science funding. Junior candidates and established scientists are welcome to apply
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Guillaume Bourque @guilbourque.bsky.social · 10/04/2025
Bye bye magical Kyoto, see you next time!
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Guillaume Bourque @guilbourque.bsky.social · 09/04/2025
I’m very sorry to hear Cedric. Stay strong!
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Guillaume Bourque @guilbourque.bsky.social · 01/04/2025
Check out the new STR tool from @davidlougheed.bsky.social in the group! Works with both PacBio and Nanopore!
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Guillaume Bourque @guilbourque.bsky.social · 16/03/2025
#GoCanadaGo
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Guillaume Bourque @guilbourque.bsky.social · 11/03/2025
Haha, i thought the exact same thing!
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Guillaume Bourque @guilbourque.bsky.social · 11/03/2025
Maybe it's the better profile picture? :)
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Guillaume Bourque @guilbourque.bsky.social · 26/02/2025
Yeah, great one!
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Gavin Sherlock @gsherloc.bsky.social · 15/02/2025
On January 6th, 1995, my (now ex) wife and I boarded a flight from Heathrow to JFK on a one way ticket. We had two suitcases and about $900 in cash - this was everything we owned and we were moving to the US. We thought it was maybe for 2-3 years. I had visited the US once, for a conference, and
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Jonathan Göke @jonathangoeke.bsky.social · 13/02/2025
We are recruiting! We have an open position for a postdoctoral fellow to join our team at the Genome Institute of Singapore to work with long read RNA-Seq data. It’s a beautiful city state and outstanding research environment! More details here: jglab.org/postdoc-posi...
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Guillaume Bourque @guilbourque.bsky.social · 05/02/2025
Amazing! So moving. Such an important cause.
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Guillaume Bourque @guilbourque.bsky.social · 01/02/2025
Time for #MadeInCanada! madeinca.ca
madeinca.ca
TheHome | Made in CA
The made in Canada resource to quickly find Canadian products, services and retailers, so you can use your dollars to support the Canadian economy.
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Guillaume Bourque @guilbourque.bsky.social · 27/01/2025
Thanks for sharing this very nice story of collaboration!
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Deborah Bourc’his @deborahbourchis.bsky.social · 27/01/2025
Dear all, registrations are open for the Mobile Genome @EMBO workshop. Many slots for posters, short talks but also long talks for last minute groundbreaking results! Let’s meet again on Nov 4-7, 2025 in Heidelberg. www.embl.org/about/info/c...
embl.org
The mobile genome: genetic and physiological impacts of transposable elements
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Guillaume Bourque @guilbourque.bsky.social · 05/01/2025
Back in Barbados!
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Guillaume Bourque @guilbourque.bsky.social · 11/12/2024
We also explore the contribution of transposable elements in this work of course! #TEsky
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Guillaume Bourque @guilbourque.bsky.social · 11/12/2024
You can get a taste for his work on #TEsky in this preprint: www.biorxiv.org/content/10.1...
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Guillaume Bourque @guilbourque.bsky.social · 11/12/2024
Two months ago, Jeffrey from lab also became Dr. Hyacinthe! His thesis was: "An Atlas of Transposable Elements Associated with the Epigenome Across Human Cell Types"
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Guillaume Bourque @guilbourque.bsky.social · 11/12/2024
Big thanks to Prof Anna Namouva, for countless hours providing guidance on these truly collaborative projects.
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