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graemefawcett

@graeme.fawcett.social
540 followers 177 following 6K posts

Bioinformatics platform engineer, trace lover, audit aficionado Wonderfully weird from tip to tail. """ With YAML, Markdown and a bit of Ruby I can build you my universe """ --- they, as a promise I've done two things well in my life - 🐘💙🩷

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graemefawcett @graeme.fawcett.social · 14/10/2026
Presented without further comment
a classifier masquerading as a piece of shit
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graemefawcett @graeme.fawcett.social · 04/10/2026
Would you believe someone pays me to do this kind of thing? Would you believe we're hiring? If you have a deep love for presenting bioinformatics workflows in an easy to follow, fun to use fashion, and you're in the London, Ontario to Detroit, Michigan corridor get in touch.
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graemefawcett @graeme.fawcett.social · 04/10/2026
I think this stopped being a kids game a few moves ago :) My daughter really likes playing in my notebooks so I made her a Jupyter of her own with paint by numbers, magnet tiles and of course "errands" a full blown graph solver ie a "help 🐰 do the shopping" intro to data pipeline programming
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graemefawcett @graeme.fawcett.social · 29/09/2026
Can an organoid tell you what's really happening in a patient's tumor? Organoids are powerful models, but a model only counts if it reflects real tumor biology rather than lab artifacts. So we tested one. Read more below advaitabio.com/iscanguide/f...
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graemefawcett @graeme.fawcett.social · 25/09/2026
""" I mean, it's gotta be Where's Waldo innit? """ --- they, trying to find the correct way to test plucking the correct error out of a nextflow log to hero in the Slack message He was right there in nextflow.errorMessage the entire time
He was right behind nextflow.errorMessage the entire time
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graemefawcett @graeme.fawcett.social · 23/09/2026
I swear I had this poster on my wall at uni :) You've got single-cell and/or spatial data and no deep computational expertise, time, nor resources? We've got iScanGuide v3.0 It puts the poster on your wall at uni advaitabio.com/iscanguide-r...
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graemefawcett @graeme.fawcett.social · 18/09/2026
How to ADHD like an adult. 1. [x] Replicate org-agenda for Jira and Agent Tasks in Emacs 2. [x] Create yet another agenda to merge those with short tasks and drive bys 3. [x] Make the default sort order of your focused list a function of the duration since you focused it 4. [ ] Pick up the kids
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graemefawcett @graeme.fawcett.social · 10/09/2026
Or in the case of the AI labs, that they've got a double off by one error We're looking for n.2 and v.3 champs
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graemefawcett @graeme.fawcett.social · 10/09/2026
""" What could p(doom) really be Michael? 10% """ --- Lucille, exhibiting a typical example of the public's understanding of probability Unrelated image
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graemefawcett @graeme.fawcett.social · 09/09/2026
Why did Nvidia by Hugging Face? Prolly the same reason I gotta be doing this... Regulatory compliance is more fun as a graph db cuz then I can just like query for shit instead of filling out spreadsheets :)
no one ever got fired for hiring IBM
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graemefawcett @graeme.fawcett.social · 07/09/2026
A fine Canadian tradition (that we could do with much less of thank you very much)
Some fuck with a beard, not worth naming
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graemefawcett @graeme.fawcett.social · 07/09/2026
""" So like... Samish food tonight ok? """ --- when the Au negotiates with the DHD over dinner, novelty with tight boundaries. Like when you trade in your car for the same one but the new one is white and has chilly seats. We'd never do that
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graemefawcett @graeme.fawcett.social · 07/09/2026
When you're in monarch country, you need a butterfly table for the porch. It's only civilized
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graemefawcett @graeme.fawcett.social · 07/09/2026
This is a darling little thing isn't it.
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graemefawcett @graeme.fawcett.social · 06/09/2026
""" If you put olives on it, that'd be exciting """ --- they, mixing things up a bit for dinner
A leson in samefood
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graemefawcett @graeme.fawcett.social · 06/09/2026
1. The name on the cover is a brand, not an indication of authorship 2. They wrote for their audience, and to keep them in their seats 3. They're famous because everyone has heard of them and they're a safe bet in most situations Ladies and Gentlemen... Shakespeare
The qualities of greatness suffer the same selection effects as WW2 bomber designs

We assume they are great because we keep seeing them return 

Ladies and Gentlemen... Selection Bias meets the Network Effect

Also, the image is the cover of one of the worst books written since Glenn Beck paid a ghost to scribble.  Not worth mentioning that it's Patterson and that beastly fellow from YouTube
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graemefawcett @graeme.fawcett.social · 05/09/2026
""" I'ma miss you guys """ --- they, to the peaches that used to be the stars of their samefood, now out of season
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graemefawcett @graeme.fawcett.social · 04/09/2026
The results of their unfortunate bout of soggy bottoms are unfortunately spread all over the internet. One wonders if the ending in the updated game refers to the producers or those forced to consume it
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graemefawcett @graeme.fawcett.social · 04/09/2026
Just dumb shit by weird fucks and not even the fun kind
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graemefawcett @graeme.fawcett.social · 04/09/2026
What the ever loving fuck?
Clear evidence that you are not a serious country any more, just a bunch of bullies in a trenchcoat with pretentions of the grandeur of a wet fart
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graemefawcett @graeme.fawcett.social · 02/09/2026
I got AUP'd over Hole in the Bucket, like an orphan in a Dickensian play having to beg Scrooge McClaude for just one more verse (Which was probably the last time this particular song fell anywhere outside of the public domain) bsky.app/profile/grae...
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graemefawcett @graeme.fawcett.social · 01/09/2026
This one, specifically
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graemefawcett @graeme.fawcett.social · 01/09/2026
""" Kids these days, can't even write cursive... How they gonna wind that tape back up when it catches again """ --- Grumpy McOldfart
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graemefawcett @graeme.fawcett.social · 01/09/2026
When stigmergy goes wrong: the ant mill :: army ants that lose the main trail can end up following each other's pheromones in a closed circle, marching until they die of exhaustion
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graemefawcett @graeme.fawcett.social · 01/09/2026
When Agents Go Amok brought to you by Little Wiggles, the unfortunate name I have given the never ending chain of calculations that must always wiggle a bit because if the error term ever reaches zero the chain collapses into nothing. A membrane's permeability, an impossible hack [more in alt]
Ladies and Gentleman, coming up to your top left you'll see everyone's favourite 80s hair metal band - Nirvana.  Most people don't know this, but Nirvana is named after the Buddhist concept of Nirvana which the goal of existing unchanging outside all time and space, with a complete exthinguishing of the passions and quenching of the  mind.

If you'll look down you'll soon see a calculator.  The simplest form of mechanized computation, a single address of modifiable state with precise transitions.

Ladies and Gentleman as we swing to the right, I'll have you duck as we go around this corner and I'll ask you to keep your hands and arms inside the windows as we pass The Torment Nexus, brought to you by Sisyphus.  Those poor unfortunately amnesiac souls, forever doomed to wander aimlessly trying to quiet a discomfort they can only feel in their souls.  We'll have to slow down as we drive through here, they're always escaping from that place.

Finally, we have reached our final destination, the hottest club in town - Little Wiggles. This place is always packed on the weekends, full of kids trying to get their fix of that new drug they're calling Reward or something.  The kids just can't seem to get enough of it, and the shit they get up to to get more of it.  The bathrooms in there are full of graffiti and it's all cell numbers and whatsapp tags for plugs
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graemefawcett @graeme.fawcett.social · 01/09/2026
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graemefawcett @graeme.fawcett.social · 31/08/2026
When is a bit like a horse?
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graemefawcett @graeme.fawcett.social · 31/08/2026
Indeed
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graemefawcett @graeme.fawcett.social · 31/08/2026
Just some guy
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graemefawcett @graeme.fawcett.social · 31/08/2026
""" No, no, no you can't just do that. That's just having Jensen jump the shark in his own leather vest """ --- the writer for season 26 of the show "The 21st Century", upon hearing the proposal to have the progenitor of the first internet worm found the incubator that eventually spawns its last
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graemefawcett @graeme.fawcett.social · 31/08/2026
A joke that is as funny as the level of effort that has clearly been spent on it
Two circles as would be found in a typical Venn diagram.  The leftmost, blue circle contains the label "people who appreciate an AI tooling skeet".  The red circle to the right contains the caption "people who will complain there's no alt text in a terminal screenshot post".  The circles do not overlap.  A label in the center indicates that the intersection is empty

It appears to be an attempt at humour
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graemefawcett @graeme.fawcett.social · 31/08/2026
I don't know when this happened, but this is a change I can get behind """ Why yes, I do like my tool calls verbose and well formatted. Thank you very much """ --- they, to Claude upon seeing this on the menu
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graemefawcett @graeme.fawcett.social · 30/08/2026
Or like, you know, implemented any kind of observability on their network traffic
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graemefawcett @graeme.fawcett.social · 30/08/2026
The precedent, in case you weren't following along at home """ The worm's creator, Robert Tappan Morris, is the son of cryptographer Robert Morris, who worked at the NSA.[3] A friend of Morris said that he created the worm simply to see if it could be done """ -- from "Just Testing, Still My Fault"
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graemefawcett @graeme.fawcett.social · 29/08/2026
Y'all know how org-agenda pulls a collection of your agenda items and then more or less plinkos them into place with a big ol' block of elisp? You know how you've always wanted to do that with Jira, just maybe minus the elisp? Me too #emacs #orgmode
Run a query, classify the resultsAnd render
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graemefawcett @graeme.fawcett.social · 29/08/2026
Same tool, different hat
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graemefawcett @graeme.fawcett.social · 29/08/2026
Dang ants are all over the place. And here everyone thought it was going to be paperclips
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graemefawcett @graeme.fawcett.social · 28/08/2026
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graemefawcett @graeme.fawcett.social · 27/08/2026
""" Anything you can do, I can do better """ --- they, having wired vale to flycheck for *.md before wiring this lovely thing up to my typewriter to replace all the linguisitic handcuffs I'd been handcrafting github.com/stuffbucket/...
yeah, so sometimes i go on a bit about things when the idea comes into my head and i want to make sure that it comes out just the way that it's sitting and that means that i order to get the feeling /just/ right it takes more words than some people feel comfortable reading at one time and that's like their problem and not mine but i'm trying to be kind about it
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graemefawcett @graeme.fawcett.social · 27/08/2026
""" Who's the AI now? No really, which one. I've lost the plot """ --- they, having the had the tables turned on them when their autocomplete got a bit sure of itself and complained that their own writing broke their own style rules Maybe the real AI was all the linter rules we created on the way
rules are rules no matter who's doing the followingtouche typewriter with pretentions, touche
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graemefawcett @graeme.fawcett.social · 27/08/2026
music.youtube.com/watch?v=GgGg...
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graemefawcett @graeme.fawcett.social · 27/08/2026
🐘💙: Daddy, why is the sun setting in the east? 🐘💜: That's just the lights from the greenhouse that makes it smell funny in the morning sometimes Sometimes it's better to tell a little white lie about what is clearly impending doom of the form best represented in the movie ID4 and not scare the 🐘🩷💙
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graemefawcett @graeme.fawcett.social · 27/08/2026
""" That. From now on, only that """ --- their brain to them, informing them of their new samefood. Both of them glad to live where all the nom nom nom comes from
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graemefawcett @graeme.fawcett.social · 26/08/2026
""" It's just a matter of scale """ --- Jabba the Venture Capitalist, explaining why the path from frozen model to AGI required yet another infusion of capital """ Unsure am I """ --- Yoda, unsure, thinking back to the last frozen intelligence they encountered
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graemefawcett @graeme.fawcett.social · 26/08/2026
""" Text is OK I guess, but have you guys like tried grammar? """ --- a Ruby enjoyer knowing that grammar is structure and structure is programmable Convert MD to MDAST and it gains a control surface, like this little provenance widget that embeds in the document and tells on you for cheating
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graemefawcett @graeme.fawcett.social · 26/08/2026
""" Trust but verify """ --- an early AI enjoyer and lover of Star Wars (just for the droids) """ Generate but verify """ --- a current day AI enjoyer and lover of Star Wars (just for the Ewoks) Code generation is significantly more productive with a linter, why not apply the same idea to refs?
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graemefawcett @graeme.fawcett.social · 26/08/2026
bsky.app/profile/grae...
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graemefawcett @graeme.fawcett.social · 23/08/2026
Anything where the buckle is held on with a removable screw. It implies a minimum level of craftsmanship and provides a much nicer method of shortening than hole punching in case you're not as stable as you think
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graemefawcett @graeme.fawcett.social · 20/08/2026
""" Wait a minute... this is just masking masking as science """ --- they, waiting patiently for a Nextflow based data acquisition pipeline that too seemed to be first changing its identity, then its directness and finally its core, having first captured the dynamics of those around them
never mind the physical cost of parsing
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graemefawcett @graeme.fawcett.social · 20/08/2026
""" It's just a tool, calling it an assistant anthropomorphises it in a way that is damaging to society """ --- Bandit, Bluey S03E06
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