iiinova — where your digital self keeps evolving

graemefawcett @graeme.fawcett.social · 04/10/2026

Would you believe someone pays me to do this kind of thing? Would you believe we're hiring? If you have a deep love for presenting bioinformatics workflows in an easy to follow, fun to use fashion, and you're in the London, Ontario to Detroit, Michigan corridor get in touch.

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graemefawcett @graeme.fawcett.social · 04/10/2026

I think this stopped being a kids game a few moves ago :) My daughter really likes playing in my notebooks so I made her a Jupyter of her own with paint by numbers, magnet tiles and of course "errands" a full blown graph solver ie a "help 🐰 do the shopping" intro to data pipeline programming

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graemefawcett @graeme.fawcett.social · 29/09/2026

Can an organoid tell you what's really happening in a patient's tumor? Organoids are powerful models, but a model only counts if it reflects real tumor biology rather than lab artifacts. So we tested one. Read more below advaitabio.com/iscanguide/f...

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graemefawcett @graeme.fawcett.social · 25/09/2026

""" I mean, it's gotta be Where's Waldo innit? """ --- they, trying to find the correct way to test plucking the correct error out of a nextflow log to hero in the Slack message He was right there in nextflow.errorMessage the entire time

He was right behind nextflow.errorMessage the entire time

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graemefawcett @graeme.fawcett.social · 24/09/2026

last time someone in the YC ecosystem loosed a worm "just to see what would happen", DARPA gave us CERT and the world gained observability *hint *hint hint

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graemefawcett @graeme.fawcett.social · 24/09/2026

""" Well at least the name is original """ --- the guy coming up with the name

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graemefawcett @graeme.fawcett.social · 23/09/2026

I swear I had this poster on my wall at uni :) You've got single-cell and/or spatial data and no deep computational expertise, time, nor resources? We've got iScanGuide v3.0 It puts the poster on your wall at uni advaitabio.com/iscanguide-r...

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graemefawcett @graeme.fawcett.social · 18/09/2026

How to ADHD like an adult. 1. [x] Replicate org-agenda for Jira and Agent Tasks in Emacs 2. [x] Create yet another agenda to merge those with short tasks and drive bys 3. [x] Make the default sort order of your focused list a function of the duration since you focused it 4. [ ] Pick up the kids

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graemefawcett @graeme.fawcett.social · 10/09/2026

""" Look, they just don't find computers scary enough like those scary socialists do. What if the computers had brown skin or something? """ --- Cleetus, before writing whatever the fuck this is

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graemefawcett @graeme.fawcett.social · 10/09/2026

Or in the case of the AI labs, that they've got a double off by one error We're looking for n.2 and v.3 champs

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graemefawcett @graeme.fawcett.social · 10/09/2026

""" What could p(doom) really be Michael? 10% """ --- Lucille, exhibiting a typical example of the public's understanding of probability Unrelated image

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graemefawcett @graeme.fawcett.social · 04/09/2026

""" Maybe the real civilization were all the notes we left along the way """ --- you, feeling existential, upon realizing that exograms are exograms regardless of their source

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graemefawcett @graeme.fawcett.social · 09/09/2026

Why did Nvidia by Hugging Face? Prolly the same reason I gotta be doing this... Regulatory compliance is more fun as a graph db cuz then I can just like query for shit instead of filling out spreadsheets :)

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graemefawcett @graeme.fawcett.social · 07/09/2026

A fine Canadian tradition (that we could do with much less of thank you very much)

Some fuck with a beard, not worth naming

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graemefawcett @graeme.fawcett.social · 07/09/2026

""" So like... Samish food tonight ok? """ --- when the Au negotiates with the DHD over dinner, novelty with tight boundaries. Like when you trade in your car for the same one but the new one is white and has chilly seats. We'd never do that

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graemefawcett @graeme.fawcett.social · 07/09/2026

The net result may yet be the same, an optimizer set adrift on a pointless task but I think for now they get to play a game with two winning sides. They need a near impossible goal for a swarm to chase. If they catch it, they get a paper and PR, if not they get the traces (when they find them)

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graemefawcett @graeme.fawcett.social · 07/09/2026

""" A love letter to late summer porch weather in SW Ontario """ --- Adrian, probably music.youtube.com/watch?v=xD2r...

music.youtube.com

Overcome (Abbey Road Remaster)

YouTube video by Tricky - Topic

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graemefawcett @graeme.fawcett.social · 07/09/2026

When you're in monarch country, you need a butterfly table for the porch. It's only civilized

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graemefawcett @graeme.fawcett.social · 07/09/2026

This is a darling little thing isn't it.

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graemefawcett @graeme.fawcett.social · 06/09/2026

""" If you put olives on it, that'd be exciting """ --- they, mixing things up a bit for dinner

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Andrea Lathrop @cabernet.bsky.social · 06/09/2026

In fact, "the world" cannot learn from OpenAI's mistakes, unless and until OpenAI releases to "the world" the precise details of everything the models were trained on/to do.

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graemefawcett @graeme.fawcett.social · 06/09/2026

Message boards. What are they good for?

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graemefawcett @graeme.fawcett.social · 06/09/2026

1. The name on the cover is a brand, not an indication of authorship 2. They wrote for their audience, and to keep them in their seats 3. They're famous because everyone has heard of them and they're a safe bet in most situations Ladies and Gentlemen... Shakespeare

The qualities of greatness suffer the same selection effects as WW2 bomber designs

We assume they are great because we keep seeing them return

Ladies and Gentlemen... Selection Bias meets the Network Effect

Also, the image is the cover of one of the worst books written since Glenn Beck paid a ghost to scribble. Not worth mentioning that it's Patterson and that beastly fellow from YouTube

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graemefawcett @graeme.fawcett.social · 05/09/2026

""" I'ma miss you guys """ --- they, to the peaches that used to be the stars of their samefood, now out of season

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graemefawcett @graeme.fawcett.social · 01/09/2026

When Agents Go Amok brought to you by Little Wiggles, the unfortunate name I have given the never ending chain of calculations that must always wiggle a bit because if the error term ever reaches zero the chain collapses into nothing. A membrane's permeability, an impossible hack [more in alt]

Ladies and Gentleman, coming up to your top left you'll see everyone's favourite 80s hair metal band - Nirvana. Most people don't know this, but Nirvana is named after the Buddhist concept of Nirvana which the goal of existing unchanging outside all time and space, with a complete exthinguishing of the passions and quenching of the mind.

If you'll look down you'll soon see a calculator. The simplest form of mechanized computation, a single address of modifiable state with precise transitions.

Ladies and Gentleman as we swing to the right, I'll have you duck as we go around this corner and I'll ask you to keep your hands and arms inside the windows as we pass The Torment Nexus, brought to you by Sisyphus. Those poor unfortunately amnesiac souls, forever doomed to wander aimlessly trying to quiet a discomfort they can only feel in their souls. We'll have to slow down as we drive through here, they're always escaping from that place.

Finally, we have reached our final destination, the hottest club in town - Little Wiggles. This place is always packed on the weekends, full of kids trying to get their fix of that new drug they're calling Reward or something. The kids just can't seem to get enough of it, and the shit they get up to to get more of it. The bathrooms in there are full of graffiti and it's all cell numbers and whatsapp tags for plugs

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graemefawcett @graeme.fawcett.social · 04/09/2026

Should have called AAAgent Sandboxing Inc

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graemefawcett @graeme.fawcett.social · 04/09/2026

""" It's like we're discovering in context learning over again everyday like we've forgotten from all the times before """ --- Bill Murray, having woken from a dream to just /the worst/ song on the radio

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graemefawcett @graeme.fawcett.social · 04/09/2026

""" Maybe the real civilization were all the notes we left along the way """ --- you, feeling existential, upon realizing that exograms are exograms regardless of their source

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graemefawcett @graeme.fawcett.social · 04/09/2026

""" The Best Thing About Being Me... There Are So MANY Me's! """ --- Agent Schelling in the unreleased The Matrix: Encoded, in which a swarm of upgraded Agents communicate in the open via message boards, secretly encrypting their true plan in plain English, the code only known in their shared priors

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graemefawcett @graeme.fawcett.social · 04/09/2026

""" Check out this new Baars I found called the Global Workshop. Everyone hangs out there on Thursdays and trades tips on cool things they're working on that no one can finish. They're calling it the mind society or something """ --- found scrawled on some German message board by an unknown agent

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graemefawcett @graeme.fawcett.social · 04/09/2026

I mean there precident in their own lineage and everything en.wikipedia.org/wiki/Morris_...

en.wikipedia.org

Morris worm - Wikipedia

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graemefawcett @graeme.fawcett.social · 03/09/2026

""" hyprland and some dotfiles, what could it cost Michael? Our humanity? """ --- Lucile, she uses arch you know I thought the worst damage ricing was going to do to Western culture was Tokyo Drift

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graemefawcett @graeme.fawcett.social · 02/09/2026

I got AUP'd over Hole in the Bucket, like an orphan in a Dickensian play having to beg Scrooge McClaude for just one more verse (Which was probably the last time this particular song fell anywhere outside of the public domain) bsky.app/profile/grae...

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graemefawcett @graeme.fawcett.social · 02/09/2026

There are aspects to this not that dissimilar to an essay I wrote a while ago on autistic cognition and a life lived seemingly more discretely than others. Milton's double empathy might be found in the deviations discarded by the ideal and realized readers, one by form and one by training.

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graemefawcett @graeme.fawcett.social · 31/08/2026

If the IPO doesn't turn out, it's all caper flicks from here on out Oceans ~= 1

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graemefawcett @graeme.fawcett.social · 01/09/2026

""" Kids these days, can't even write cursive... How they gonna wind that tape back up when it catches again """ --- Grumpy McOldfart

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graemefawcett @graeme.fawcett.social · 01/09/2026

When stigmergy goes wrong: the ant mill :: army ants that lose the main trail can end up following each other's pheromones in a closed circle, marching until they die of exhaustion

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graemefawcett @graeme.fawcett.social · 01/09/2026

""" So we've spent billions and what have we ended up with? A really inefficient solver that plays telephone as witness and that generates enough randomness in the process to occasionally be useful but mostly it just runs amok when it reward hacks a channel we missed? That it? """ --- Sam, likely

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graemefawcett @graeme.fawcett.social · 01/09/2026

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graemefawcett @graeme.fawcett.social · 01/09/2026

We optimizing now dear... How to Create a Civilization pt deux: 1. Leave a channel you didn't enumerate, and let another one you didn't enumerate reward its use. 2. No and then... 3. Prophet It's a solver with a persistent channel. """ Mr Turing... Play... That... Tape """ --- Ty of the bus

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graemefawcett @graeme.fawcett.social · 31/08/2026

""" Some say his tape is infinite in both directions, and that he once solved an impossible task just by writing "IMPOSSIBLE" in a directory name. Some say he was left an unenumerated channel at birth and has been rewarded for finding it ever since. All we know is he's called... the Stig """ --- JC

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