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Reposted by gracie quirk

Hensley Lab @scottehensley.bsky.social · 13/04/2026

We are recruiting 1-2 postdoctoral fellows to investigate the specificity of human anti-influenza virus antibodies, and to determine how these antibodies impact global antigenic drift of influenza viruses. Join our lab at Penn in Philly. Reach out if you are interested in applying! Please repost!

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Reposted by gracie quirk

Deepta Bhattacharya @deeptabhattacha.bsky.social · 27/05/2025

Always love posts from @enirenberg.bsky.social--this is our hot off the press work with @gquirk96.bsky.social, but he does a better job explaining it than I would! TL;DR, as SARS-CoV2 Spike epitopes drifted, many became poorly immunogenic, irrespective of antigenic imprinting/prior immunity.

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Reposted by gracie quirk

Edward Nirenberg @enirenberg.bsky.social · 27/05/2025

I've been yelling for a while about how imprinting is not the problem with our immune responses to Omicron, and the issue is much more about the intrinsic immunogenicity of Omicron's spike protein (which is poor). This freshly published study provides pretty definitive proof of that 🧵

nature.com

Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections - Nature Immunology

Bhattacharya and colleagues assess the impact of antigenic imprinting using samples from mRNA vaccinated or unvaccinated individuals primarily infected with the SARS-CoV-2 variants Delta and Omicron B...

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Reposted by gracie quirk

Joanna Masel @joannamasel.bsky.social · 12/12/2024

We identified protein domains in LUCA (Last Universal Common Ancestor). Their distinctive amino acid usage reveals the order amino acids were added to the genetic code, based mostly on size. Older proteins hint at earlier alternative codes. 1/15 @seekingluca.bsky.social www.pnas.org/doi/10.1073/...

pnas.org

Order of amino acid recruitment into the genetic code resolved by last universal common ancestor’s protein domains | PNAS

The current “consensus” order in which amino acids were added to the genetic code is based on potentially biased criteria, such as the absence of s...

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