iiinova — where your digital self keeps evolving

Hiren Joshi @glyco.me · 16/09/2026

I was tempted to post the black and white version of this online, but we have enough conflict in the world. Fans of 6000 word essays on engraved elevator buttons in New York will appreciate the font.

210

Hiren Joshi @glyco.me · 02/07/2026

Claude has learnt that apparently all I care about is glyco, which isn’t entirely unfair.

110

Hiren Joshi @glyco.me · 06/06/2026

I had a funny conversation yesterday when I told them about FoldDISCO and we landed on what the universal mime movement for disco is - the staying alive point.

130

Hiren Joshi @glyco.me · 03/12/2025

www.nasa.gov/missions/osi...

100

Hiren Joshi @glyco.me · 12/11/2025

Peter Panum was a Dane working in Germany, and the amazing brutalist building we were based in (and are now next to) is named after him.

020

Hiren Joshi @glyco.me · 12/11/2025

Questionably fun fact: The study of endotoxin in modern age was kicked off by Peter Panum (studying putrid fluids). He had also done work on albumen, releasing “something” with dilute acid hydrolysis. Eichwald in 1865 did that same reaction on mucin, arguably starting the study of glycoproteins.

German text with the original citation from Eichwald

131

Hiren Joshi @glyco.me · 25/10/2025

Pretty low-effort example of plagiarism here.

000

Hiren Joshi @glyco.me · 08/08/2025

Sad, but probably inevitable news from Vodafone AU. I have been sitting on an ancient mobile phone plan for the past 25 years, with no minimum cost for infrequent usage, and they’re finally removing the plan. Are there any reputable places to port Australian mobile numbers to for e.g., VOIP?

010

Hiren Joshi @glyco.me · 26/06/2025

Kim Jong-un inspects the latest in North Korean shark tank technology.

Kim Jong-un inspecting the latest in shark tank technology, that looks suspiciously like a water slide.

100

Hiren Joshi @glyco.me · 21/06/2025

This Lorenz Oken guy might just be on to something. The article mixes slime and mucus interchangeably, but it is a good read about the relative rarity of complex life. www.asimov.press/p/slime

010

Hiren Joshi @glyco.me · 15/06/2025

CCG (incl @manno.se and @xylobecs.bsky.social) representing at the half marathon across the Øresund bridge today. Lovely weather for it!

140

Hiren Joshi @glyco.me · 10/06/2025

Well, it turns out that you can actually make PyMOL do quite a lot of stuff. Here's the full workflow, integrating the amazing ReGlyco into PyMOL to re-glycosylate the LDLA linker. There's some serious magic needed to get it running as fast as it is within PyMOL. @elisafadda.bsky.social

2276

Hiren Joshi @glyco.me · 06/05/2025

A little bit of glycan binding structure for your Tuesday.

261

Hiren Joshi @glyco.me · 23/04/2025

I have this script I use to munge citations in word docs, that spelunks into the XML and creates Zotero/Mendeley compatible field codes. I figured it couldn’t be that hard to get it working for EndNote. It was. Even Gemini told me not to, which made me even more determined. Now it works.

110

Hiren Joshi @glyco.me · 18/04/2025

It’s literally just this:

docker run -it --user $(id -u):$(id -g) --volume $(pwd):/app -e GEMINI_API_KEY=REDACTED paulgauthier/aider --model gemini-2.5-pro

000

Hiren Joshi @glyco.me · 09/04/2025

The ream is defined as 20 quires of 25 sheets. And why…?

110

Hiren Joshi @glyco.me · 09/04/2025

I mean, it’s one ream of paper, Fiona. What would it cost, $10?

120

Hiren Joshi @glyco.me · 01/04/2025

"Your scientists were so preoccupied with whether or not they could that they didn't stop to think if they should" @elisafadda.bsky.social , you know we could make an awesome plugin.

230

Hiren Joshi @glyco.me · 30/03/2025

Yet still a vast improvement over the old model!

110

Hiren Joshi @glyco.me · 30/03/2025

I’m as against the AI slop it’s all too easy to make, but it’s still pretty impressive tech. I always test the latest stuff on my standard prompt - riffing on Harrison Ford in “Extraordinary Measures”.

ChatGPT generated image of Harrison Ford juggling SNFG symbols on a beach, wearing a white lab coat

151

Hiren Joshi @glyco.me · 21/03/2025

GTDC1, B3GNTL1. And 1.5 years ago! doi.org/10.1016/j.ce...

020

Hiren Joshi @glyco.me · 16/01/2025

Do we need another isoform expressed? Pretty common to have two isoforms of ST8SIA expressed in a cell. Do most of the other cells also have a dormant capacity to make PolySia (activated by having whatever this other factor is?)

Extract from Figure 4C of https://doi.org/10.1016/j.isci.2022.104419

010

Hiren Joshi @glyco.me · 15/01/2025

My daughter is learning the art of text messaging, in a bilingual manner. Sometimes messages don’t quite come across in the way she expected.

Text message with the text “sleigh, Queen”

1100

Hiren Joshi @glyco.me · 20/12/2024

Wait, is that WINE as in WINE Is Not an Emulator, i.e., the windows compatibility layer on Linux? If so..

Yo dawg, I heard you like emulation, so I put an emulator on your emulated os on your emulated hardware.

120

Hiren Joshi @glyco.me · 19/11/2024

Already there! You can go to the list, and click on pin, fiddle around a bit, and get your BlueSky feed to default to glyco all the time, because we all know that's the only thing worth social media-ing about!

000

Hiren Joshi @glyco.me · 22/08/2024

It kind of just flops the sugars on the structure. We know α-Man doesn’t really change secondary structure on β-strands/sheets (e.g., cadherins). So I guess that’s consistent. Otherwise 🤷🏽‍♂️ ? We might be able to see this using CryoEM/whatever.

100

Hiren Joshi @glyco.me · 13/05/2024

If you’re interested in putting glycoproteins into #alphafold3 but don’t know which glycans to put in, I have a tool for you. You can either search for proteins, and it will pre-populate a JSON job file for you, or you can draw biologically plausible glycans, and get the AF code for them.

200

Hiren Joshi @glyco.me · 11/10/2023

elifesciences.org/reviewed-pre...

Monkey side-eye meme, representing the current mood of people/projects/technologies relying on un-validated antibodies for protein ID.

102

Hiren Joshi @glyco.me · 10/10/2023

I think I need to spend some time digesting exactly what is going on here.

200