iiinova — where your digital self keeps evolving

Reposted by Gabriel Galea

Journal of Cell Science @jcellsci.bsky.social · 05/10/2026

Read more about this research in our ‘First person’ interview with Elizabeth-Ann Legere. In this interview, Elizabeth-Ann shares that part of this research was supported by a @biologists.bsky.social Travelling Fellowship to visit @glgalea.bsky.social’s lab. journals.biologists.com/jcs/article/...

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Gabriel Galea @glgalea.bsky.social · 24/03/2026

Delighted with this new paper. Key findings I'm most interested in following up: - Mechanical cues impact cell shape long after the cue ends, - Surface ectoderm (SE) cells have cryptic lamellipodia which may enable collective crawling, - SE becomes progressively jammed www.cell.com/current-biol...

cell.com

Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis

Pérez-Verdugo et al. show that hindbrain neuropore closure is driven by surface ectoderm actomyosin purse-string tension and active migration. These forces create reproducible patterns of cell elongat...

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Gabriel Galea @glgalea.bsky.social · 21/01/2026

In @eLife.bsky.social: Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation doi.org/10.7554/eLif... @hpscenthusiast.bsky.social

doi.org

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Reposted by Gabriel Galea

Alex Grigas @agrigas.bsky.social · 12/12/2025

How do sparse mesenchymal cells, with unique stellate arms spanning large gaps between cells, maintain their network while still flowing during development? In our new preprint we describe the avian PSM as a fluid under tension and develop new theory to explain it: www.biorxiv.org/content/10.6...

biorxiv.org

Sparse mesenchymal cell networks as a fluid under tension

Sparse mesenchymal cellular networks are ubiquitous across animals, shaping both embryonic and adult structures through dynamic interactions with epithelia. Yet, the physical principles underlying the...

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Gabriel Galea @glgalea.bsky.social · 11/12/2025

Fascinating work on the biomechanics of mesenchymal tissues right here:

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Gabriel Galea @glgalea.bsky.social · 20/05/2025

2. iPSC neuroepithelial models by @hpscenthusiast.bsky.social identifying a patient mutation in VANGL2 which diminishes apical constriction in this human model www.biorxiv.org/content/10.1...

Figure excerpt showing recoil following annual laser ablation of WT and VANGL2-knock in neuroepithelial cultures

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Gabriel Galea @glgalea.bsky.social · 20/05/2025

1. Laser ablation study of the mouse cranial neuroepithelium, led by Juana de la O in Adam Martin's lab (MIT), identifying regional differences in apical tension and anisotropy in the lateral neural folds (consistent with a recent paper from Eric Brooks' lab) www.biorxiv.org/content/10.1...

Illustration of the mouse cranial neural folds and quantification of recoil following laser ablations in the midline or lateral neural folds

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Gabriel Galea @glgalea.bsky.social · 20/05/2025

#ApicalConstriction and #DevBio afficionados - we've got two new pre-prints you may be interested in, below:

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Reposted by Gabriel Galea

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · 16/05/2025

A lateral tension model for cranial mouse neural tube closure www.biorxiv.org/content/10.1101/202…

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Reposted by Gabriel Galea

James Briscoe @jamesbriscoe.bsky.social · 17/01/2025

A couple of weeks left to apply to join Development's *Pathway to Independence* programme Support & mentoring for post-docs on the academic job market Deadline: January 31 journals.biologists.com/dev/pages/pi...

journals.biologists.com

Development PI Programme | Development | The Company of Biologists

Development PI Programme | Development | The Company of Biologists Development's Pathway to Independence programme Development is excited to announce our second call for our Pathway to I...

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Reposted by Gabriel Galea

UCL Faculty of Life Sciences @ucllifesciences.bsky.social · 18/12/2024

Applications are now open for our UCL East London Scholarship. The value of the bursary is full home tuition fees plus £16,000 maintenance. The deadline is Thursday 26 June 2025. Find out more, including eligibility criteria: www.ucl.ac.uk/scholarships...

ucl.ac.uk

UCL East London Scholarship

This scholarship supports the ambitions of east Londoners by funding the fees and living costs of all UCL East Master's programmes and select School of Management programmes.

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Reposted by Gabriel Galea

Amoyel lab @amoyellab.bsky.social · 04/12/2024

We're hiring a postdoc! Please forward to people you know who are looking for positions. Interested in studying how metabolism is wired to support fertility? 🔬🪰 Come join us! Ad to go live next week, but informal enquiries encouraged.

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Reposted by Gabriel Galea

James Briscoe @jamesbriscoe.bsky.social · 04/12/2024

Applications open for a new cohort of @dev-journal.bsky.social *Pathway to Independence* fellows Know a #devbio post-doc about to enter the academic job market? Would they benefit from a little support & mentoring? Spread the word Deadline 31 Jan 2025 journals.biologists.com/dev/pages/pi...

journals.biologists.com

PI programme | Development | The Company of Biologists

PI programme | Development | The Company of Biologists Development's Pathway to Independence programme Development is excited to announce our call for our Pathway to Independence program...

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Reposted by Gabriel Galea

Shinuo Weng @shinuoweng.bsky.social · 30/11/2024

To mark Black Friday, we are excited to share our latest work, "Planar polarized force propagation integrates cell behavior with tissue shaping during convergent extension." Now online in Current Biology. authors.elsevier.com/a/1kATd3QW8S...

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Gabriel Galea @glgalea.bsky.social · 22/11/2024

Congrats to Fernanda - she really came up with some really creative solutions to our questions!

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Reposted by Gabriel Galea

Eirini Maniou @emaniou.bsky.social · 22/11/2024

Happy to share our new preprint with Vernanda Perez-Verdugo, @shilabanerjee.bsky.social @glgalea.bsky.social We show that mechanical feedback drives shape and spatial order of the surface ectoderm in hindbrain neuropore closure.

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Reposted by Gabriel Galea

Shiladitya Banerjee @shilabanerjee.bsky.social · 22/11/2024

How do physical forces influence spatiotemporal cell patterning during tissue morphogenesis? Our latest preprint integrates theoretical modeling with live imaging of mouse embryos to reveal how mechanosensitive feedback drives self-organized cell patterning during hindbrain neuropore morphogenesis.

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