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Giovanni Schiesaro

@giovanschi.bsky.social
59 followers 61 following 23 posts

PhD student at DTU Biosustain. Working on fungal GPCRs and more. - 1/3 of Biologi per la scienza

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Giovanni Schiesaro @giovanschi.bsky.social · 07/09/2026
See you at #PYFF9
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Giovanni Schiesaro @giovanschi.bsky.social · 19/07/2026
journals.asm.org/doi/10.1128/...
journals.asm.org
Spatiotemporal compartmentalization of NADPH oxidase signaling coordinates cell fusion and predatory behavior in nematode-trapping fungi | mBio
Reactive oxygen species (ROS) are not only toxic byproducts of mitochondrial activity but also important signaling molecules in eukaryotes. To fulfill this signaling role, ROS production must be tight...
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Reposted by Giovanni Schiesaro
FeM - Funghi e Micologia @funghimicologia.bsky.social · 25/05/2026
The role of fungal G protein-coupled receptors in interspecies cell-cell communication academic.oup.com/femsre/advan...
academic.oup.com
The role of fungal G protein-coupled receptors in interspecies cell-cell communication
Abstract. Fungi occupy a wide range of ecological niches in which they compete or associate with other organisms through the perception of external signals
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Giovanni Schiesaro @giovanschi.bsky.social · 27/06/2026
Our review on the role of fungal G protein-coupled receptor (GPCRs) in interspecies cell-cell communication is finally out.  academic.oup.com/femsre/artic...
academic.oup.com
The role of fungal G protein-coupled receptors in interspecies cell–cell communication
The review covers recent advances on fungal GPCRs, including their molecular interactions and physiological roles. Illustration created with BioRender.com.
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Giovanni Schiesaro @giovanschi.bsky.social · 08/06/2026
Mycol brings the main steps into one simple interface: 1. Upload images 2. Annotate cells (manually or with the SAM2 model) 3. Fine-tune segmentation and classification models 4. Quality-control predictions 5. Export cell counts, annotated images, models, and morphology data
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Giovanni Schiesaro @giovanschi.bsky.social · 08/06/2026
Here, we developed Mycol, a user-friendly app to automate image analysis of fungal or any biological cells of interest. A big congrats to all the co-authors and special recognition to Sam Bradley for the tremendous effort behind this work. Link: www.biorxiv.org/content/10.6...
biorxiv.org
Mycol: A user-friendly app for automating analysis of microscopy images
Microscopy image analysis is central to modern biology, yet many available platforms remain inaccessible to non-specialist users because they require advanced technical expertise, code-based workflows...
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Giovanni Schiesaro @giovanschi.bsky.social · 08/06/2026
Last year, during my external research stay in Córdoba, I spent several weeks manually quantifying Fusarium oxysporum spore germination, which ended up in one supplementary figure. My wish after this experience was to prevent future researchers from spending too much time on this tedious task.
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Giovanni Schiesaro @giovanschi.bsky.social · 08/06/2026
Studying fungal organisms can be challenging, and we need more versatile tools or protocols that could be easily transferred from one fungal organism to another.
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Giovanni Schiesaro @giovanschi.bsky.social · 22/11/2025
Finally out! www.nature.com/articles/s41...
nature.com
A yeast surface display platform for characterizing CAR T cell responses to cancer antigens - Nature Communications
Chimeric antigen receptor T (CAR-T) cell therapy uses engineered donor T cells to recognize and eliminate cancer cells through cognate antigen-dependent activation. Here authors develop an alternative...
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Giovanni Schiesaro @giovanschi.bsky.social · 20/11/2025
🍅
link.growkudos.com
Can yeast help us fight fungal crop diseases?
Every year, fungal pathogens destroy more than 10% of the world’s major crops, threatening global food security, biodiversity, and farmers’ livelihoods. It’s a silent crisis that costs billions and fu...
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Giovanni Schiesaro @giovanschi.bsky.social · 28/10/2025
Thank you! I didn’t try yet (lack of time). But if you have any interesting targets we can have a chat :-)
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Giovanni Schiesaro @giovanschi.bsky.social · 28/10/2025
And many other things that you can find at the first link! A big, big, big thank you to all the co-authors of this study and our funding agencies @villumfonden.bsky.social and DTU Biosustain.
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Giovanni Schiesaro @giovanschi.bsky.social · 28/10/2025
In addition, we have found that - Fungal chemotropism correlates well with yeast mating (measured in diploid frequency). - Fusarium oxysporum signaled robustly across different abiotic factors, while other fungal GPCR–pheromone interactions were more sensitive to changes
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Giovanni Schiesaro @giovanschi.bsky.social · 28/10/2025
Our study revealed that the supplementation of peptides, identified through screening with YeMaP, can interfere with the cell-cell communication of the phytopathogenic fungus Fusarium oxysporum, reducing roots penetration in the early stage of infection of tomato.
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Giovanni Schiesaro @giovanschi.bsky.social · 28/10/2025
Here, we have developed a tool called Yeast Mating Platform (YeMaP). With YeMaP, we can isolate fungal G protein-coupled receptors (GPCRs) and study the interaction with their ligand (in yeast) in a much faster (high-throughput) way.
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Giovanni Schiesaro @giovanschi.bsky.social · 28/10/2025
Suppose we can understand how fungi “talk” to each other at the molecular level. In that case, we can start designing more precise and targeted antifungal strategies that protect crops without relying on fungicides
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Giovanni Schiesaro @giovanschi.bsky.social · 28/10/2025
Can yeast help us fight fungal crop diseases?🌾 A yeast mating platform for multiplex screening of fungal GPCR–ligand interactions www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Reposted by Giovanni Schiesaro
Oded Rechavi @odedrechavi.bsky.social · 27/06/2025
So cool, a novel archaeon with a super small genome and no metabolic genes! "An unprecedented level of metabolic dependence on a host, a condition that challenges the functional distinctions between minimal cellular life and viruses." www.biorxiv.org/content/10.1...
biorxiv.org
A cellular entity retaining only its replicative core: Hidden archaeal lineage with an ultra-reduced genome
Defining the minimal genetic requirements for cellular life remains a fundamental question in biology. Genomic exploration continually reveals novel microbial lineages, often exhibiting extreme genome...
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Reposted by Giovanni Schiesaro
Dr. Jen M @awesomebiota.bsky.social · 22/05/2025
This paper makes me CACKLE. Every so often a fungus comes along that is like "oh, you think you understand genetics? lol. You're cute." and completely upends everything we thought we knew. Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi | Science 🧪 #academicsky 🧵
science.org
Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi
Nuclei define eukaryotes, enabling macromolecular compartmentalization and cellular regulation. Each nucleus is believed to contain one or more haploid sets of chromosomes (1N). However, we discovered...
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Giovanni Schiesaro @giovanschi.bsky.social · 08/05/2025
Can we link satellite images and fungal community composition in the soil? Yes! How? Check this paper. It was a pleasure to collaborate on this story. Big congrats to Mathies and all the co-authors. www.nature.com/articles/s43...
nature.com
Exploring crop health and its associations with fungal soil microbiome composition using machine learning applied to remote sensing data - Communications Earth & Environment
Crop health is improved by abundance of beneficial soil fungal genera and reduced by abundance of soil fungal pathogens, according to analysis of satellite-derived normalized difference vegetation ind...
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Giovanni Schiesaro @giovanschi.bsky.social · 07/03/2025
👀
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Reposted by Giovanni Schiesaro
Sonja Billerbeck @billerbecks.bsky.social · 03/02/2025
Out now! We consolidated >600 Dutch yeast and characterised their activity against spoilage yeasts and relevant human and plant pathogens, focusing on yeasts that secrete antifungal proteins. Great resource for biocontrol and beyond. pubmed.ncbi.nlm.nih.gov/39875071/
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Giovanni Schiesaro @giovanschi.bsky.social · 08/01/2025
Half way PhD presentation: done 👍🏻. Our first story “A synthetic platform for multiplex screening of cell-cell communication between soil fungi” is already available on bioarchive: www.biorxiv.org/content/10.1...
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Giovanni Schiesaro @giovanschi.bsky.social · 21/12/2024
I highly recommend the documentary "Hunt for the Oldest DNA" on the scientific journey of Eske Willerslev and collaborators. Good science requires perseverance and... time. If your PhD didn’t meet your expectations, remember that there are projects that have lasted 16 or more years.
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Giovanni Schiesaro @giovanschi.bsky.social · 17/12/2024
A big thank you.
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Giovanni Schiesaro @giovanschi.bsky.social · 21/11/2024
Not all yeast heroes wear capes.
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Giovanni Schiesaro @giovanschi.bsky.social · 20/11/2024
Best tattoo ever!
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