Why can cells keep protein aggregation under control for years and then suddenly tip into disease?
Our new JCP paper introduces a simple phase-plane model for in vivo protein aggregation that captures the tug-of-war between aggregate formation and clearance in cells.
pubs.aip.org/aip/jcp/arti...
pubs.aip.org
A universal phase-plane model for in vivo protein aggregation
Neurodegenerative diseases are driven by the accumulation of protein aggregates in the brain of affected individuals. The aggregation behavior in vitro is well