genomerambler.bsky.social @genomerambler.bsky.social · 17hFlanderization rules everything around me 100
Reposted by @genomerambler.bsky.socialColin @colin-fraser.net · 02/10/2026So when it produces right answers to these, it is certainly not regurgitating memorized answers. It's doing ~*~*~SoMeThInG eLsE~*~*~. There are all kinds of questions to ask about the nature of whatever it's doing. Maybe it understands math in its mind. Maybe it's doing mindless symbol manipulation. 91266
Reposted by @genomerambler.bsky.socialColin @colin-fraser.net · 02/10/2026But, by my back of the envelope calculations, to store every 12 x 12 digit addition problem would take about 43 trillion terabytes, which is thousands of times more data than all the data in the entire world. So for a randomly generated one, it is essentially certain not to be in the training data 31304
Reposted by @genomerambler.bsky.socialWill Oremus @willoremus.com · 02/10/2026feels like there is a group of smart and well-intentioned people who long ago made up their minds that AI Is Bad, swore off using it, and now get all their info about AI from each other. not saying they're wrong that ai is bad! but i think they're gradually losing touch with what it is and does 234960105
Reposted by @genomerambler.bsky.socialDavid W (aka Flex NP) @rnflex.bsky.social · 29/09/2026Finally it reduces hepatic insulin resistance so far that I'm not sure it can go much lower. A 55-60% reduction in fasting insulin. Also it raised Cystatin-C based GFR by 6-10ml/min. Legit a medical miracle/fix it all/Mary Sue ass drug as @proptermalone.bsky.social would say. 316218
Reposted by @genomerambler.bsky.socialutility function of unknown etiology @curiousaboutupdog.bsky.social · 29/09/2026the place is a message... and part of a system of messages... don't pay attention to it! reading this message was useless to us. We considered ourselves to be a Bayesian culture. this place is not a place of rationality... no highly esteemed inference is commemorated here... nothing valued is here 0466
Reposted by @genomerambler.bsky.socialRationallyDense (they/she/he/any) @rationallydense.bsky.social · 22/09/2026Half of math is discovering the beautiful regularities of the universe and the other half is noticing some property and finding out there are exactly 73 other objects which have that property and they all come out of the nightmares of Cthulhu. 0174
Reposted by @genomerambler.bsky.socialRyan Hisner @ryanhisner.bsky.social · 09/09/2026...a fantastic & IMO criminally overlooked study on ORF3a discovered "3DBs", large vesicles loaded with S and M whose production requires ORF3a. And mutations in the region of ORF3a crucial to their formation had a dramatic effect on S1/S2 cleavage, increasing it 10-fold... 134
Reposted by @genomerambler.bsky.socialKevin Mitchell @wiringthebrain.bsky.social · 09/09/2026With a little time now past, I'm wondering what pop gen peeps make of this paper... do the findings seem solid? 233
genomerambler.bsky.social @genomerambler.bsky.social · 08/09/2026VAULTS MENTIONED ALERT ALERT ALERT 110
Reposted by @genomerambler.bsky.socialRyan Hisner @ryanhisner.bsky.social · 05/09/2026One aspect of the usual arsenal of lab-leak proponents seems contradictory to me: the claim that because we've found no close intermediate/precursor for SARS-CoV-2, a lab leak is therefore more likely. But there are >1000 nuc changes between the closest related sarbecos & SARS-CoV-2... 1153
genomerambler.bsky.social @genomerambler.bsky.social · 27/08/2026life evolves via mutation and selection science evolves via undergrads fucking up a protocol and postdocs figuring out the fuckup made things better 081
Reposted by @genomerambler.bsky.socialAlex Crits-Christoph @acritschristoph.bsky.social · 06/08/2026see also this work, which helps provide some helpful framing of how novel these phages are: www.biorxiv.org/content/10.6... tl;dr: I believe this work generates only marginally novel phages, which have only a moderate likelihood of working, that decreases the more novel they get.biorxiv.orgQuantifying evolutionary novelty and design efficiency in generative genome designGenerative genome design models can now produce previously unobserved genome-length sequences, but assessing their capabilities is complicated by limitations in functional prediction. The ability to e... 45719
Reposted by @genomerambler.bsky.socialRob Noble @robjohnnoble.bsky.social · 23/05/2026Julie Dragon announces a fourth type of transmissible cancer at ISEEC 2026! Brown bullhead transmissible melanoma. Two lineages so far identified in the northeast US. Seems to be more widespread and >100 years old. Paper under review. 1134
Reposted by @genomerambler.bsky.socialFantômas, Le contrebandier de DEI @theefantomas.bsky.social · 21/05/2026Wario and Waluigi are are dark reflections of Mario and Luigi, The most notable difference is that Mario and Luigi are Italian, whereas Wario and Waluigi are French. 082
Reposted by @genomerambler.bsky.socialrev. howard arson @theophite.bsky.social · 11/02/2026a LLM is like an ant living on a map of your hometown. the relations between landmarks in the universe it lives in correspond to the landmarks in your hometown, but it does not live in your hometown. it lives in a two-dimensional embedding of your hometown. 424227
Reposted by @genomerambler.bsky.socialAndrew Reeves @andrewsshi.bsky.social · 01/12/2025At the end of the day, if you're constantly on the pointy end of the breakdown of society, you're going to get kind of effed up. This is one reason that pretty much every large municipality needs drastically more cops. 091
Reposted by @genomerambler.bsky.socialFlinthearth Gloomgold @flintheartglomgold.bsky.social · 01/12/2025The 1-2 punch of "gangs provide identity and create financial, social *and emotional* support where it is otherwise absent" and "cops are indistinguishable from gangs" does lead to some in-hindsight obvious conclusions about secondary, unspoken motivations cops have for closing ranks when questioned 011313
Reposted by @genomerambler.bsky.socialSE Gyges @segyges.bsky.social · 22/08/2025like. fundamentally, at deep deep bedrock, rationalism as it currently exists is path-dependent on *not* asking questions about who is paying for what, who is manipulating you, and whose power you are contributing to 181
genomerambler.bsky.social @genomerambler.bsky.social · 29/07/2025kinda worried that freddie deboer might be having a manic episode rn, he's being unusually aggressive on substack i guess he probably has a better support system now but he also has a new baby...concerning 010
Reposted by @genomerambler.bsky.socialrev. howard arson @theophite.bsky.social · 23/05/2025want to see a super weird hallucination? i fed it a somewhat oblique SCP to see if it could pick the actual story out of a collection of documents -- basically, an early "reader test" for a genre which can fail if readers can't read between the lines -- and it started producing nonsense science. 1011215
Reposted by @genomerambler.bsky.socialBoo H @dahoovster.bsky.social · 21/05/2025Combine this video tech with the “grandma they arrested me in Tijuana” scam and every Nana’s bank account nationwide will be empty within a month 2141
Reposted by @genomerambler.bsky.socialRyan Moulton @moultano.bsky.social · 12/05/2025Apparently the root cause of this article is that the judge in one of the antitrust lawsuits thought these numbers were small instead of big. (They're big.) 3782
Reposted by @genomerambler.bsky.socialRyan Moulton @moultano.bsky.social · 12/05/2025This isn't true. I'm the person who ran the experiments this is BSing about. When search results are worse, people attempt fewer tasks. When they're better they attempt more. 925353
Reposted by @genomerambler.bsky.socialAlex Crits-Christoph @acritschristoph.bsky.social · 15/02/2025It's a cyanobacteria on the outside, fungus on the inside. Well, sort of. The fungus lives in the extracellular sheath produced by the Cyanobacteria, and therefore are not really true endophytes. But the cyanos do create the external structure. 22612
Reposted by @genomerambler.bsky.socialWill Ratcliff @wcratcliff.bsky.social · 06/02/2025It is such an intuitive way of approaching the problem, that anyone who believes in 'individual level selection' on animals, plants, or unicellular eukaryotes absolutely believes in group selection, as these individuals are, in fact, groups. 2141
Reposted by @genomerambler.bsky.socialDrug Monkey @drugmonkey.bsky.social · 03/02/2025eRA commons access via login dot gov is down again. Different error page this time. 12185
Reposted by @genomerambler.bsky.socialgodoglyness @godoglyness.bsky.social · 29/01/2025"You know the neopolitan mathematician Borelli used bioanchors to examine with great niceity the proposition of heavier than air flight, but was totally wrong?" 353
genomerambler.bsky.social @genomerambler.bsky.social · 11/11/2024need to read, but if it holds up i think this is the first direct evidence that capsid formation is important for an Arc-mediated phenotype 240
Reposted by @genomerambler.bsky.socialItai Yanai @itaiyanai.bsky.social · 09/11/2024Doing good science is 90% finding a science buddy to constantly talk to about the project. 22877215
Reposted by @genomerambler.bsky.socialDiego del Alamo @delalamo.xyz · 10/11/2024IMO the best near-term application for recent de novo protein design methods is to replace antibodies as experimental reagents. mAbs & pAbs are a pain to work with & are prone to reproducibility problems. Yet for some reason we only hear de novo designed proteins discussed as potential therapeutics 3144
genomerambler.bsky.social @genomerambler.bsky.social · 08/11/2024what's the smallest possible endogenously fluorescent peptide possible, I wonder? 120
genomerambler.bsky.social @genomerambler.bsky.social · 08/11/2024in retrospect it makes sense that high inflation would have worse consequences for the incumbent than high unemployment high inflation affects everyone, high unemployment is mostly salient to the unemployed, which is...not everyone 120
genomerambler.bsky.social @genomerambler.bsky.social · 07/11/2024lmao apparently you cant put ebola sequences into af3 320
genomerambler.bsky.social @genomerambler.bsky.social · 05/11/2024if we have trees cilia could they grow taller 110
genomerambler.bsky.social @genomerambler.bsky.social · 04/11/2024ok but tucker's kinda right about nukes ngl 110
genomerambler.bsky.social @genomerambler.bsky.social · 04/11/2024oddly enough i did a fairly intensive literature review on whether squirrels carry rabies about a decade ago, after i got bit by a hungry squirrel i decided i was safe but went to the doctor to appease my mom, the doctor also assured me i was safe 010
Reposted by @genomerambler.bsky.socialWill Ratcliff @wcratcliff.bsky.social · 01/11/2024OK folks, I want to share with you my best homebrew use case for LLMs in teaching. Here, I’ll show you how to make detailed, textbook-style notes for your students based on a transcript of your lecture and your PowerPoint. I’ve done this for the last 2 semesters and the students love it. 1/16 35316
genomerambler.bsky.social @genomerambler.bsky.social · 01/11/2024chatgpt strongly believes that there is a book called "The Great Extinctions: What They Tell Us About the Future" and frankly i agree with chatgpt that this book really should exist 120
genomerambler.bsky.social @genomerambler.bsky.social · 31/10/2024just saw the mating flight of a yellowjacket queen extremely cursed once in a lifetime natural history observation 000
genomerambler.bsky.social @genomerambler.bsky.social · 31/10/2024it makes intuitive sense that prophages are more likely to carry beneficial genes than proviruses (because they can be excused) but I'm struggling to formalize this intuition 220
Reposted by @genomerambler.bsky.socialHelen Branswell 🇨🇦 @helenbranswell.bsky.social · 30/10/2024#H5N1 #birdflu has been found in a pig in Oregon, #USDA and the state's Ag Dept announced today. The significance of this is unclear at this point, but in general, H5 in pigs would not be a good thing. www.statnews.com/2024/10/30/h...statnews.comBird flu found in a pig in U.S. for the first time, raising concerns about potential risks to humansH5N1 bird flu virus has been found in a pig in the U.S. for the first time, raising concerns about potential risks to humans. 19239
genomerambler.bsky.social @genomerambler.bsky.social · 30/10/2024I've been needing to use the term "longitudinal" in a piece of writing for like, a year, and it just wouldn't come to me going to tattoo it on my face so this doesn't happen again 130
genomerambler.bsky.social @genomerambler.bsky.social · 30/10/2024huh gary (the name) isn't short for anything this feels wrong i htink i will name my son garold 021
