Matthew Maurano, John Stamatoyannopoulos and colleagues identify 64,597 allelically imbalanced SNPs that influence transcription factor occupancy in vivo. Using these data, they develop a general scor...

Ultra-long-range genomic contacts, which are key components of neuronal genome architecture^1-3, constitute a biochemical enigma. This is because regulatory DNA elements make selective and s...

Features of higher-order chromatin organization-such as A/B compartments, topologically associating domains and chromatin loops-are temporarily disrupted during mitosis^1,2. Because these st...

Posttranslational modifications of histones (PTMs) are associated with specific chromatin and gene expression states^1,2. Although studies in Drosophila melanogaster have revealed phenotypic...

Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...