Short-course and long-course radiotherapy yield similar overall survival rates in patients treated for locally advanced rectal adenocarcinoma.

Endoscopic remission in pediatric Crohn disease occurred at lower infliximab trough levels among patients with previous adalimumab exposure.

Xenobiotic-associated liver injury increased nearly 4-fold, with medications, specifically acetaminophen, driving most cases.

In patients with CD undergoing primary anastomosis, an intraoperative abscess alone does not predict increased risk for complications.

Inadequate lymph node harvest in patients with rectal adenocarcinoma was linked to worse survival outcomes.

Coffee's effect on gut health is nuanced. Some studies suggest favorability; others link coffee or caffeine to worse reflux or specific risks.

Ultrasound-derived LIID can invasively identify MASH, while LSM accurately detects liver fibrosis, potentially reducing the need for liver biopsy.

Anemia is common in autoimmune gastritis and independently linked to IFA positivity, while iron-deficiency anemia is more frequent with H pylori.

Proton pump inhibitors improve nighttime heartburn and GERD-related sleep disturbances.

Acute intolerance symptoms was identified as a primary driver of developing difficult-to-treat ulcerative colitis.

Five-year follow-up found excisional hemorrhoidectomy had the best outcomes, while laser hemorrhoidoplasty offered similar effectiveness with less postoperative pain.

Fecal calprotectin accurately identified colorectal inflammation in chronic diarrhea, potentially reducing unnecessary colonoscopies.

Prior decompensation is linked to higher mortality and further decompensation after variceal hemorrhage, identifying a high-risk subgroup.

Disorders of gut-brain interaction-like symptoms affect 34.4% of children with IBD and are linked to poorer QOL, higher anxiety, and maladaptive behavior.

Restrictive diets are prescribed to 16% of patients with eating disorder histories receiving gastroenterology care.

Risankizumab achieves higher rates of corticosteroid-free clinical, endoscopic, and quality-of-life outcomes than ustekinumab among patients with moderate to severe CD.

Patients with psoriasis and obesity may experience a reduced response to biologics, though further research is needed to confirm these findings.

Bowel urgency is inconsistently evaluated in a real-world setting of patients treated for ulcerative colitis.

High outdoor artificial light at night was associated with lower odds of IBD and fewer outpatient visits and hospitalizations.

The risk for PV is greater in patients with type 2 diabetes who received DPP-4 inhibitors compared with those who received other medications.

Patients with CD have higher all-cause mortality than matched control individuals, while UC mortality remains comparable in the biologic era.

Lean MASLD is not a uniform condition. Underweight status and greater cardiometabolic burden are linked to worse outcomes.

CYP2C19 genotype influences pediatric EoE response to PPIs, with intermediate/slow metabolizers showing the greatest benefit from high-dose therapy.

Early-life PFAS exposure is associated with higher fecal calprotectin levels throughout childhood.

Restarting antiplatelet or anticoagulant therapy after GI bleeding lowers major vascular events and mortality despite a modest increase in recurrent bleeding.

Mild and moderate infections in IBD are common and linked to steroids, JAK inhibitors, anti-TNF therapy, smoking, female sex, and comorbidities.

Although most IBD clinicians recognize the importance of discussing sexual health, few do so routinely because of time constraints and other factors.

Early anti-TNF therapy improves 1-year remission without increasing serious adverse events and reduces operation when combined with percutaneous drainage.

Plant-based foods and whole grains are linked to better liver health, while red meat, excess protein, and sodium are linked to worse liver outcomes.

New AASLD guidelines on evaluating and selecting pediatric liver transplant candidates focus on pre-transplant assessment, organ allocation, and more.

Adults aged 45 to 49 years have higher FIT participation but lower neoplasia detection, supporting risk-stratified CRC screening.

Among individuals with overweight, screening those with cardiometabolic risk factors identified 94% of MASLD cases.

Dupilumab is safe and highly efficacious for eosinophilic esophagitis, with weekly and semiweekly dosing producing comparable results.

Repeat colonoscopy achieves a 96.1% cecal intubation rate and detects lesions often missed by radiographic imaging.

Water cooling after colorectal ESD halves PECS risk and shortens the procedure time without compromising resection success or safety.

Right- vs left-sided colectomy lowers dyslipidemia risk by 20%, with no difference in diabetes or hypertension.

Total integrated acidity exposure outperformed acid exposure time in predicting PPI response and improved GERD patient stratification.

Four-week pancreatic duct stent retention after ERCP reduces the need for endoscopic stent removal without increasing pancreatitis or complications.

End-to-side ileocolonic anastomosis is linked to lower Crohn disease recurrence, less blood loss, and shorter operative times.

Sexual distress affects 39% of patients after ileal pouch-anal anastomosis for UC and is linked to bowel dysfunction, anxiety, and depression.

Weight loss and lower ultra-processed food intake — not diet type — improve liver fat among those with MASLD.

High socioecological burden delays colorectal cancer treatment, which supports patient-level social risk screening.

One in 10 patients with primary biliary cholangitis has CKD, with hypertension, diabetes, and advanced liver disease increasing CKD risk and mortality.

Statin use is associated with lower risk for HCC, hepatic decompensation, and all-cause mortality in chronic liver disease.

Patients with MASLD-related cirrhosis have similar 1-year survival and post-TIPS complication rates as those with alcohol- or viral-related cirrhosis.

Those with pathologically confirmed pancreatic precursor lesions and their first-degree relatives have significantly higher risk for pancreatic cancer.

Completing at least 2 rounds of annual stool testing reduces long-term colorectal cancer risk, with smaller benefits from additional rounds.