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Connor Garrels

@garrels.bsky.social
38 followers 64 following 3 posts

PhD Candidate - Reichow Lab at OHSU He/Him

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Reposted by Connor Garrels
Reichow Lab @reichowlab.bsky.social · 13/08/2026
Long-timescale simulations reveal multi-ion flux through wide pore gap junction channels -– and an unexpected transition involving loop–NT domain interactions that suggest a dynamic ensemble of micro-states define the “open” channel www.biorxiv.org/content/10.6...
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Connor Garrels @garrels.bsky.social · 08/07/2026
A very nice write up about our recent work taking a peek at Cx46/50 channel-channel interactions! Thanks, @structurabio.bsky.social!
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Reposted by Connor Garrels
Ben Barad @baradlab.com · 08/07/2026
My personal summer of code continues with another ChimeraX plugin - this time, MorphometricsX! Load quantified meshes from morphometrics (or pycurv) in ChimeraX with color-by-quantification and display alongside tomos and particles. Coming to the toolshed soon! #teamtomo github.com/baradlab/mor...
Screenshot of MorphometricsX rendering mitochondrial membrane surfaces in chimera with color-by-quantification.
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Reposted by Connor Garrels
Reichow Lab @reichowlab.bsky.social · 27/06/2026
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Reposted by Connor Garrels
Ben Barad @baradlab.com · 27/06/2026
Just in time for the weekend, the 2nd beta for our Surface Morphometrics 2.0 release: github.com/GrotjahnLab/.... Beyond the major API change from the first beta (which used for the michigan class!), this one includes a major overhaul of the dual gaussian fitting for thickness and refinement.
github.com
Release 2.0.0b2 · GrotjahnLab/surface_morphometrics
A quality and robustness release on top of 2.0.0b1, focused on the density-profile bilayer fitting (mesh refinement and thickness measurement), a forgiving centralized config system, and packaging ...
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Connor Garrels @garrels.bsky.social · 01/06/2026
Very excited about our new work highlighting the role of lipids in mediating multi-channel assemblies of Cx-46/50!
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Reposted by Connor Garrels
Reichow Lab @reichowlab.bsky.social · 21/02/2025
#NIHFundedDiscovery How do cells avoid the "kiss of death"? Gap junctions share life-saving signals—but under stress, they shut down to prevent spreading cytotoxic damage. #CryoEM reveals the molecular switches behind this process! www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...
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Reposted by Connor Garrels
Reichow Lab @reichowlab.bsky.social · 06/12/2024
Super excited for this one! High-res #cryo-EM ensemble of sHSP/client complexes, uncovering 'Mechanism of small heat shock protein client sequestration and induced polydispersity' www.biorxiv.org/content/10.1... A teaser...👇
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Reposted by Connor Garrels
Reichow Lab @reichowlab.bsky.social · 02/12/2024
Pleased to share the peer-reviewed version of our latest work on resolving the complexities of a-crystallins/sHSP's: www.nature.com/articles/s41... A timely release of this story... as it is a great setup to the next one, coming soon!!
nature.com
Dynamic fibrillar assembly of αB-crystallin induced by perturbation of the conserved NT-IXI motif resolved by cryo-EM - Nature Communications
Here the authors show that mutating αB-crystallin’s NT-IXI motif transforms polydispersed oligomers into ordered fibrils, enabling cryo-EM to provide insights into the principles of high-order assembl...
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Connor Garrels @garrels.bsky.social · 02/12/2024
Inaugural post sharing a newly updated version of our little protocol for high quality fiducial removal in #CryoET processing
protocols.io
Tomogram Reconstruction and Gold Fiducial Removal with WarpTools, Etomo, and Fidder
While gold nanoparticle fiducials greatly improve tilt-series alignment in cryo-electron tomography data, they can cause artifacts during later image processing steps. We presen...
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