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Reposted by Teng Gao

Vijay G. Sankaran @bloodgenes.bsky.social · 15/02/2026

Check out this important advance in mitochondrial 🧬 lineage tracing by @gaoteng.bsky.social and @wengchen.bsky.social from our group, in collaboration with @jswlab.bsky.social 👇👇

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Teng Gao @gaoteng.bsky.social · 15/02/2026

We turned to population genetics for a solution. The resulting approach, MitoDrift, integrates Wright-Fisher drift dynamics with phylogeny inference via a hidden Markov tree model, enabling us to produce confidence-calibrated lineage trees.

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Teng Gao @gaoteng.bsky.social · 15/02/2026

Mitochondrial lineage tracing brought exciting new capabilities to single-cell genomics. However, a core problem remains: unlike classical lineage recorders, mtDNA mutations can drift and disappear as cells divide, preventing us from precisely decoding lineage history.

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Teng Gao @gaoteng.bsky.social · 15/02/2026

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Reposted by Teng Gao

Waggoner Lab @labwaggoner.bsky.social · 13/02/2026

@biorxivpreprint.bsky.social Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humans www.biorxiv.org/content/10.6... @bloodgenes.bsky.social @jswlab.bsky.social @bostonchildrens.bsky.social @hhmi-science.bsky.social @broadinstitute.org

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