iiinova — where your digital self keeps evolving

Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 22h

Decoding ferroptosis via integrated multi-omics analyses in rice blast 🌾 💡 Ferroptosis links iron homeostasis, ROS/redox imbalance, and lipid peroxidation to both rice immunity and Magnaporthe oryzae infection. onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.com

Decoding ferroptosis via integrated multi‐omics analyses in rice blast

The rice-Magnaporthe oryzae pathosystem is presented as a host-pathogen ferroptosis model. Multi-omics insights connect ferroptosis to several cellular processes, such as iron homeostasis, reactive o...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 12/05/2026

Integrative host–microbiome modeling uncovers the implication of oral–gut translocation in advanced cirrhosis Cirrhosis drives an “oralization” of the gut microbiome, reshaping microbial metabolism toward ammonia and acetate production. onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.com

Integrative host–microbiome modeling uncovers the implication of oral–gut translocation in advanced cirrhosis

Liver cirrhosis is associated with profound disruption of host–microbiome metabolic interactions. Using paired oral and fecal metagenomics combined with genome-scale metabolic modeling, we investigat...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 17/04/2026

💪Chondroitin sulfate restores muscle mass via gut–muscle axis remodeling through sugar–bile acid metabolism reprogramming ⚙️ Enrichment of Lactobacillus johnsonii and secondary bile acids activates PAX7/NMRK2 pathways, promoting muscle regeneration. onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.com

Chondroitin sulfate restores muscle mass via gut–muscle axis remodeling through sugar–bile acid metabolism reprogramming

The graphical abstract illustrates the molecular mechanism by which chondroitin sulfate (DCS) alleviates glucocorticoid-induced myopathy through the gut–muscle axis. DCS selectively enriches L. johns...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 20/04/2026

The DGKα/PA axis drives immune evasion by activating NF-κB and upregulating PD-L1 in tumors. ⚙️ Inhibiting DGKα reduces PD-L1, enhances CTL infiltration, and improves ICI efficacy, with plasma PA as a potential biomarker in gastrointestinal cancers. onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.com

Targeting DGKα/PA axis inhibits tumor immune evasion and augments sensitivity to immunotherapy in gastrointestinal cancers

Immune checkpoint inhibitors (ICIs) have shown promising antitumor efficacy in certain types of solid tumors. However, the efficacy of ICIs remains unsatisfactory owing to the dysregulation of signal...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 21/04/2026

🧬Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells ⚙️ This attention-based model traces rare CTCs directly from blood without enrichment, supporting early detection and anti-metastatic strategies. onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.com

Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells

The detection of circulating tumor cells (CTCs) through liquid biopsy offers a non-invasive approach for accurately monitoring cancer dissemination and evaluating therapeutic efficiency. However, the...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 28/04/2026

⚡Pyridoxal Reprograms Peroxisomal Hydrogen Peroxide Metabolism to Induce Lethal Oxidative Stress in Ovarian Cancer. Unmodified PL unleashes a H2O2 storm, killing ovarian cancer cells without needing conversion! doi.org/10.1002/imm3...

doi.org

Pyridoxal Reprograms Peroxisomal Hydrogen Peroxide Metabolism to Induce Lethal Oxidative Stress in Ovarian Cancer

Pyridoxal (PL) exhibits the strongest anti-tumor activity within the vitamin B6 family, demonstrating significant ovarian cancer cell-killing efficacy in vivo, in vitro, and in patient-derived organo...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 11/05/2026

Spinal cord injury induces acute microbiome shock and system-wide transcriptomic reprogramming 🤔The newly developed SCIGAMA maps gut microbiota and systemic molecular responses after spinal cord injury (SCI). onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.com

Spinal cord injury induces acute microbiome shock and system‐wide transcriptomic reprogramming

This study investigates the systemic consequences of spinal cord injury (SCI), with a particular focus on alterations in the gut microbiome and multi-organ transcriptomic responses. We identify a rap...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 20/09/2025

🫀🦠 Gut–heart axis in #CAD: distinct microbial & metabolic shifts across normal, sCAD & ACS; ACS signatures partly reversible. Multi-omics #ML outperforms clinical risk factors in stratifying CAD subtypes. 🔗 onlinelibrary.wiley.com/doi/10.1002/... #microbiome

onlinelibrary.wiley.com

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 19/10/2025

Abnormal membrane potentials & ion channel signatures drive #tumor growth, metastasis & immune evasion 💊 Ion channel drugs, tumor-treating fields & nano-delivery offer new precision therapies 🧠 Electro-immunotherapy reshapes the TME 🔗 doi.org/10.1002/imm3... #CancerResearch #Immunotherapy

doi.org

Tumor Electrophysiology in Precision Tumor Therapy

This review highlights tumor electrophysiological hallmarks as therapeutic targets in precision oncology. We examine how membrane potential alterations and ion channel fingerprints drive malignancy, ...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 21/10/2025

🚀 #iMeta is reshaping academic communication! 📲 Multi-platform + bilingual strategy expands global reach. 📈 1.36M full-text downloads, >10K citations, IF 33.2 (2024)! 🌐 New sub-journals & events foster a vibrant research ecosystem. 🔗 doi.org/10.1002/imt2... #Journal

doi.org

iMeta: Boosting academic sharing and collaboration via social media

Social media platforms have revolutionized scientific communication by bridging gaps between researchers, academic journals, and global audiences. This article showcases iMeta, an open-access journal...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 21/10/2025

🧬 New insights into the diversity of #CRISPR–Cas systems! #Metagenomic analyses uncovered 4,112 Cas12 proteins and 6 novel subtypes. 🤖 #AI-based Cas12fam annotates 18 domains. 🌿 Cas12 subtypes show habitat-specific enrichment. 🔗 doi.org/10.1002/imo2... #microbiome #metagenomics #bioinformatics

onlinelibrary.wiley.com

Metagenomic mining reveals novel Cas12 subtypes and their evolutionary diversification

We identified 4112 Cas12 Proteins and 6 new Cas12 subtypes, revealed their significant diversity in N-terminal regions, repeat sequences, and sequences motifs. We developed an AI-driven algorithm, Ca...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 21/10/2025

🫀 Can plant sterols fight #atherosclerosis? ✅ Yes! #Stigmasterol reduces inflammatory macrophages & foam cells. 💡 It boosts cholesterol efflux, blocks ox-LDL uptake, and modulates AMPK/NF-κB/NLRP3 signaling. 📉 The result: less vascular #inflammation, healthier arteries. 🔗 doi.org/10.1002/imo2...

doi.org

Stigmasterol attenuates atherosclerosis by inhibiting inflammatory signaling and foam cell formation

Stigmasterol mitigates atherosclerotic plaque formation by modulating foam cell phenotypic alterations and cholesterol metabolism. Stigmasterol inhibits inflammatory CD86+ macrophage polarization via...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 22/10/2025

🍩 What happens when Prmt5 is lost in fat cells? 🧬 Lipid genes go down, #glucose metabolism goes up! 💥 #Triglycerides drop while phospholipid & sphingolipid diversity expands. PRMT5 emerges as a key regulator of membrane transport & #cholesterol synthesis. 🔗 doi.org/10.1002/imo2...

doi.org

Multiomics analyses reveal that PRMT5 regulates membrane transport and cholesterol synthesis in white adipocytes

Prmt5AKO downregulates genes related to fatty acid transport and triacylglycerol synthesis, while upregulating genes involved in glucose transport and cholesterol biogenesis. These changes cause alte...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 22/10/2025

💡 30 scientific recommendations from the #CHINAGUT Conference! 👩‍🔬 63 experts joined forces to shape the future of: 🦠 #Probiotics 💊 Live biotherapeutic products 💩 #FMT The goal: standardization, regulation & precision in #microbiome-based therapies. 🔗 doi.org/10.1002/imt2...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 27/10/2025

💥 Can AI solve the #antibiotic resistance crisis? 🤖 By revolutionizing every step of drug discovery—from target ID to lead optimization. 🧬 Two paths: molecular screening & de novo design. ⚙️ #AI accelerates discovery, boosts ADMET prediction & drives multi-target innovation. 🔗 doi.org/10.1002/imm3...

doi.org

Artificial Intelligence Revolutionizes Anti‐Infective Drug Discovery: From Target Identification to Lead Optimization

Artificial intelligence (AI) technology is revolutionizing antimicrobial drug development. In response to increasingly severe antimicrobial resistance challenges, AI can efficiently predict pathogen ...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 30/10/2025

🐭 #Lactiplantibacillus plantarum Hi188 promotes post-weaning growth in mice. 🧪 The #metabolite 5-HIAA activates hepatic #AhR, boosting IGF-1 production. 🧑‍💻 Metagenomic and host transcriptome data reveal that 5-HIAA is co-produced by the host–microbiota axis. 🔗 doi.org/10.1002/imo2... #microbiome

doi.org

Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice

This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the e...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 30/10/2025

🧬 CycloneSEQ #nanopore sequencing rapidly reconstructs multidrug-resistant bacterial genomes! ⚙️ 96.16% read accuracy, 99.98% assembly accuracy. 💡 Complete genomes with just 15× long reads or 5× hybrid data. 🔗 onlinelibrary.wiley.com/doi/10.1002/... #Bioinformatics #BGI

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 14/11/2025

🧬 GSE-Seq — high-throughput single-entity sequencing via droplet microfluidics! ⚙️ Integrates #barcode generation, degradable hydrogel processing & long-read #sequencing — uncovering vast microbial “dark matter.” 🔗https://doi.org/10.1002/imt2.70087

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 02/12/2025

Gut–X axis - Lin - 2025 - iMeta - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 02/12/2025

Whole #microbiota transplantation restores gut homeostasis throughout the #gastrointestinal tract - Tang - iMeta - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 08/12/2025

💡 Toward a Medical Data Element Ecosystem (MDEE) for the digital health era! 🌏 Build a comprehensive medical data ecosystem framework that spans the entire data lifecycle and offers a new perspective for advancing practice in the field. onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.com

Medical Data as a Key Asset in the Digital Health Era: A Framework for Challenges and Strategies

By conducting case studies and comparative analysis from a global perspective, this study develops the practical framework of Medical Data Element Ecosystem (MDEE)—one that facilitates MDEE construct....

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 08/12/2025

🚀iMeta has been cited over 14,000 times! ⚡️According to statistics from the Dimensions website, as of December 8, 2025, #iMeta has published 349 papers, which have been cited 14,366 times, with an average of 41.16 citations per paper, and it takes only two days to reach 100 citations.

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 12/12/2025

⚡️Using MicrobTiSDA to infer interspecies interactions from microbiome time-series data. 🔎A tool for analyzing the dynamic patterns of microbial abundance over time. The complete analysis process from data preprocessing to result visualization. onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.com

MicrobTiSDA: A flexible R package for inferring interspecies interactions and abundance dynamics in microbiome time‐series data

MicrobTiSDA is a user-friendly and flexible R package specifically designed for longitudinal microbiome data analysis. By integrating process-oriented functional modules—including data input, data pr...

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Reposted by GAN Renyou

iMeta Science @imetascience.bsky.social · 15/12/2025

Integrated multi-omics reveals how potassium sorbate may trigger acute kidney injury. ⚙️ Network toxicology, machine learning & single-cell analysis identify APP as a central hub driving oxidative stress, inflammation & endothelial–immune crosstalk. onlinelibrary.wiley.com/doi/10.1002/...