Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity-focused single-cell atlas of 708,894 periph...

Human-infecting DNA viruses remain major health threats, yet the DNA-recognition mechanisms of their nucleic acid-binding proteins (NBPs) are poorly understood. Here, we systematically profiled 103 v...

Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron-driven ferroptosis, copper-mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mn...

This review focuses on spatial omics, covering the introduction and comparison of technology platforms, explanation and recommendation of algorithm ecology, demonstration of biological applications, ....

An AI-powered multi-omics cloud platform integrating 41 standardized workflows, 126 visualization tools, and full-lifecycle research intelligence to enable accessible, reproducible, and end-to-end in...

Whether Lepidoptera harbor a conserved core gut microbiome has long remained contentious. Through large-scale microbiome profiling of folivorous larvae, their host plants, and associated soils across....

Microbiome age (MA) has emerged as an innovative biomarker of biological aging, reflecting host aging trajectories through dynamic alterations in microbial composition, function, and host–microbe int...

Spatial multi-omics of the mouse ocular globe after retinal ischemia-reperfusion (RIR) injury identifies the ganglion cell layer (GCL) as an immunometabolic niche where Trem2+ microglia closely assoc...

Multi-omics-driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome prof...

The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross-organ biomarker networks, biomarker classification, and technology-driven paradigms. It maps how biomarkers l...

The gut microbiome can be conceptualized as a distributed organ-like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication w...

We present two near-complete triticale genome assemblies and perform pan-centromere analyses across >200 haplotypes from parental species, synthetic allopolyploids, cultivars, and 337 resequenced acc...

This study suggests that the food-derived flavonoid hyperoside may act as a natural DExH-box helicase 9 (DHX9) modulator, directly targeting Thr419 of DHX9 to help resolve pathological R-loop accumul...

Genome-resolved methylomics uncovers the first DNA methylation atlas of the dairy cow rumen microbiome. Microbial DNA methylation profiles diverge between low- and high- methane-emitting dairy cows d...

Impact of representative environmental chemicals on tumor immune microenvironment (TIME). Representative environmental chemicals are ubiquitously distributed across air, soil, aquatic systems, and bi...

Current therapies for allergic rhinitis primarily provide symptomatic relief but fail to establish durable antigen-specific immune tolerance. Here, we developed an oral nano-dietary fiber (NDF) platf...

Early-pregnancy microbiome and lipidome profiling identified a microbiome-glycosphingolipid axis associated with later gestational diabetes mellitus (GDM) risk. In the prospective pregnancy cohort, w...

Limosilactobacillus reuteri Y15 (LRY15)-derived polyunsaturated fatty acids (PUFAs) restore follicular cell-cell junctions and fertility. LRY15, isolated from the intestine of alginate oligosaccharid...

Integrated single-cell RNA sequencing, spectral flow cytometry, immune-receptor repertoire profiling, and plasma proteomics revealed coordinated peripheral immune remodeling during acute scrub typhus...

The maternal–infant continuum involves critical windows of host–microbiota co-adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–...

From ecological principles to precision engineering of plant microbiomes for sustainable agriculture. The plant holobiont integrates diverse microbial niches (including rhizosphere, endosphere, phyll...

Fermentation microbiomes play essential roles in food production, feed preservation, waste valorization, and diverse sustainable industrial processes. Although multi-omics and systems biology have su...

Bazi Bushen Capsule (BZBS) mitigates age-related endometrial dysfunction by activating AMPK − SIRT3 signaling. Luteolin, a key bioactive component, restores mitochondrial homeostasis via PINK1/Parkin...

Micro- and nano-plastics (MNPs) can enter the human body through inhalation, ingestion, contact with consumer products, and iatrogenic routes. The clinical relevance of MNP exposure should be interpr...

Phage–host interactions critically shape environmental antimicrobial resistance (AMR). Using swine manure anaerobic digestion and multi-omics (metagenomics, meta-transcriptomics, and Hi-C), we mapped....

Graphical overview of explainable artificial intelligence (XAI) for farm-to-fork postharvest preservation. Postharvest deterioration accumulates across orchard, packhouse, refrigerated transportation...

Longitudinal multi-omics profiling of a nonhuman primate Rett syndrome (RTT) model reveals early systemic alterations. RTT monkeys exhibited postnatal growth retardation, intestinal structural abnorm...

Global agricultural productivity is increasingly destabilized by climate change—driven droughts, floods, extreme heat, and severe storms. Although the climate-smart agriculture (CSA) framework addres...

The human microbiota contributes to breast cancer pathogenesis and treatment response through interactions involving the oral, gut, and breast microbial niches. (Left) Multi-site dysbiosis is charact...

Decidual macrophages from recurrent spontaneous abortion (RSA) patients promote trophoblast ferroptosis and impair trophoblast cell function. Mechanistically, the CXCL2/NF-κB/HMOX1 axis mediates this...

This study presents a cross-tissue, single-cell/single-nucleus transcriptomic atlas spanning from prenatal to postnatal developmental stages in pig, characterizing 83 distinct cell types from 252,033...

Clostridium scindens and its metabolite indole-3-acetic acid (IAA) are identified as a keystone taxon and metabolic signature in centenarians. Clostridium scindens enhances microbial network stabilit...

The current version 2.0 of the microeco package represents a substantial update compared to the previously published version. Key enhancements include the addition of new classes, integration of a br...

Immunotherapy resistance presents a formidable challenge in tumor biology. While fibroblast growth factor receptor 3 (FGFR3) serves as a pivotal oncogenic driver in a multitude of cancers, the explor...

Liver cirrhosis is associated with profound disruption of host–microbiome metabolic interactions. Using paired oral and fecal metagenomics combined with genome-scale metabolic modeling, we investigat...

This study investigates the systemic consequences of spinal cord injury (SCI), with a particular focus on alterations in the gut microbiome and multi-organ transcriptomic responses. We identify a rap...

FluNexus is a versatile platform for the antigenic prediction and visualization of influenza A viruses, including: (i) Online data preprocessing module. (ii) Online antigenic prediction module. (iii)....