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Fulcrum Genomics @fulcrumgenomics.com · 17/06/2026

@tfenne.bsky.social has a new post on tuning up bioinformatics’ old plumbing: HTSJDK, jlibdeflate, chelae, mako, GLIMPSE, verifyBamID, bwa-mem3, and the low-level tools behind everyday workflows. Improve the infrastructure. Validate the behavior. Let the gains compound. Blog post 👇

Bioinformatics runs on a hidden layer of shared infrastructure. samtools, GATK, Picard, htsjdk, Snakemake, Nextflow, and the libraries beneath them carry a huge share of day-to-day work. Most of it stays out of sight, like city plumbing.

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Fulcrum Genomics @fulcrumgenomics.com · 09/06/2026

The Scantox + LatchBio + Fulcrum webinar on the new Scantox DuplexSeq™ Mutagenesis App is now available on demand. @moonlight.bio covers Fulcrum’s approach to rebuilding and validating the bioinformatics pipeline so the infrastructure could improve without changing the science. Link below👇

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Fulcrum Genomics @fulcrumgenomics.com · 21/04/2026

Deep QC should run on every sequencing dataset. In a new post, Fulcrum co-founder @tfenne.bsky.social explains why he built Riker, a modern successor to Picard designed to make rich sequencing QC fast enough to run every time. Blog: shorturl.at/oUTXk Repo: github.com/fulcrumgenom...

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Fulcrum Genomics @fulcrumgenomics.com · 13/04/2026

At #AGBTAg26, @nilshomer.com will present our work with @broadinstitute.org , @umasschan.bsky.social, and Darwin's Ark on building a comprehensive imputation reference panel for domestic cats. See the flash talk today at 4:30pm during the Plenary, or catch poster #128 during the poster sessions.

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Fulcrum Genomics @fulcrumgenomics.com · 04/03/2026

Our #bioinformatics leader & VP of Ops, @moonlight.bio, will be at #PMWC26 March 4–6 in Santa Clara. PMWC continues to push the field toward turning complex biological data into real decisions. Clint will be on-site connecting with teams advancing #genomics and #PrecisionMedicine.

PMWC 2026
Precision Medicine World Conference
March 4-6, 2026
Let's talk precision medicine bioinformatics
Attending:
Clint Valentine
VP of Operations

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Fulcrum Genomics @fulcrumgenomics.com · 27/02/2026

Open-source (nf-core–based) workflow built with @twistbioscience.com for the Twist Oncology DNA CGP Panel is now public on GitHub. Portable across local/HPC/cloud. SNVs, indels, CNVs, TMB, MSI, VEP+CIViC, QC.

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Fulcrum Genomics @fulcrumgenomics.com · 23/02/2026

@tfenne.bsky.social and @nilshomer.com are on the ground at #AGBT2026 this week. Big data. Tight timelines. Real decisions. #Bioinformatics is where complexity becomes something teams can actually use. If you’re here, let’s connect.

"AGBT meet your new bioinformatics team" with hand-drawn portraits of Nils Homer and Tim Fennell

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Fulcrum Genomics @fulcrumgenomics.com · 11/02/2026

Today is International Day of Women and Girls in Science. Grateful for the women who design studies, wrangle messy data & ask the hard questions that move research forward. Your expertise makes science stronger every day. #WomenInScience

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Fulcrum Genomics @fulcrumgenomics.com · 09/02/2026

In translational/clinical work we see bioinformatics projects fail not due to science, but because early assumptions box the data in. We plan with downstream reality in mind: biology, existing data, constraints that matter. That’s how teams move fast without rework. Let’s chat & scope your project

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Fulcrum Genomics @fulcrumgenomics.com · 28/01/2026

Most teams don’t struggle with ideas, just the momentum to get there quickly. We can help. “Start with a concept, describe the desired outcome and they can build the tools to make you successful.” — Keith Brown, Founder, Jumpcode Genomics

Text on a blue background reading "They helped us move faster than we could on our own."
Keith Brown, Founder, Jumpcode Genomics

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Fulcrum Genomics @fulcrumgenomics.com · 15/01/2026

Most ECS pipelines focus on clean error-corrected reads. What happens after variant calling is often ad hoc. MutSeqR picks up there for mutation frequency modeling, spectrum analysis, & benchmark dose estimation across ECS platforms. More detail here: 🔗 blog.fulcrumgenomics.com/p/mutseqr-op...

Schematic of a genomics pipeline with MutSeqR

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Fulcrum Genomics @fulcrumgenomics.com · 30/12/2025

Which shift are you most excited (or skeptical) about? Planning a stack upgrade? We’d love to collaborate.

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Fulcrum Genomics @fulcrumgenomics.com · 30/12/2025

Genomics is set for a big 2026: AI agents, GA4GH standards, Rust‑native workflows, long reads/ECS/SVs, and protein sequencing + AI design.

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Fulcrum Genomics @fulcrumgenomics.com · 19/12/2025

Thank you to our clients - for the challenging problems, the good questions, and the partnerships. Thank you to our team - for showing up with curiosity, rigor, and heart every single day.

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Fulcrum Genomics @fulcrumgenomics.com · 03/12/2025

Proud to share that our own Clint Valentine co-authored MutSeqR, an open-source R package for analyzing error-corrected sequencing (ECS) data. Developed with Health Canada & U Ottawa, it helps bring consistency to genetic safety research. 🔗 doi.org/10.1093/bioa... #Genomics #OpenSource #MutSeqR 🧬🖥️

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Fulcrum Genomics @fulcrumgenomics.com · 08/10/2025

@nilshomer.com , @tfenne.bsky.social , and Yossi Farjoun will be in Boston for #ASHG25. If you're going to be there, let us know! #ASHG2025

Fulcrum Genomics Nils Homer, Tim Fennell, and Yossi Farjoun depicted in a duck boat with the Boston skyline for ASHG 2025

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Fulcrum Genomics @fulcrumgenomics.com · 28/07/2025

Yesterday marked ten years since Fulcrum Genomics was founded. We took a moment to reflect: blog.fulcrumgenomics.com/p/ten-years-... Thanks to everyone who’s been part of the journey.

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Fulcrum Genomics @fulcrumgenomics.com · 13/05/2025

We believe in leaving things in a better state than we find them. Founding Partner @tfenne.bsky.social shares how our team contributes back to the open source ecosystem, strengthening the foundations on which many scientific and technical projects are built. blog.fulcrumgenomics.com/p/recent-ope...

Fulcrum Genomics logos forming a gold star

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Fulcrum Genomics @fulcrumgenomics.com · 24/04/2025

Congratulations to Nick Bailey for finishing his PhD with: “Correcting for Bias in Estimates of Watterson’s θ and Tajima's D From Missing Data in Next-Generation Sequencing”. Projects like this remind us why we love what we do. Read the paper: t.co/BhMEHxlX73 Try the software: github.com/ksamuk/pixy

Screenshot from X authored by Nick Bailey which thanks his co-authors for their help on the last chapter of his PhD. Among these are two from Fulcrum Genomics: Erin McAuley and Matt Stone.

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Fulcrum Genomics @fulcrumgenomics.com · 15/11/2024

Fulcrum Genomics is now a registered supplier on Scientist.com! Connect with us on Scientist.com and start your project with a click. Visit our profile here: app.scientist.com/providers/fu...

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Fulcrum Genomics @fulcrumgenomics.com · 04/11/2024

John Didion @jdidion.bsky.social and Tim Fennell from the Fulcrum Genomics team will be at #ASHG2024 in Denver from November 5-9. Drop us a line if you’d like to connect in person! #ASHG24 #HumanGenetics #Bioinformatics #Genomics #NGS

Photos of John Didion and Tim Fennell with logos for Fulcrum Genomics and ASHG.

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