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Brian Fisher

@fishparade.bsky.social
393 followers 415 following 275 posts

Enzyme tinkerer, FFIX stan, 10-year ReadCube subscriber

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Brian Fisher @fishparade.bsky.social · 08/10/2026
A positive transit fact for Houston! Don’t see those every day.
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Nobel Prize @nobelprize.org · 07/10/2026
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2026 #NobelPrize in Chemistry to Henri B. Kagan and Kenso Soai “for the discovery of non-linear effects and autocatalysis in asymmetric organic synthesis.”
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Brian Fisher @fishparade.bsky.social · 07/10/2026
The Soai reaction!! All the reading I did about the origins of biological homochirality for a seminar I gave on it 14 years ago is flooding back to me
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Brian Fisher @fishparade.bsky.social · 06/09/2026
Gonna fuck up a lot of databases when NM becomes NA
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Brian Fisher @fishparade.bsky.social · 04/09/2026
Validation for my just-go-real-fast aseptic technique
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Brian Fisher @fishparade.bsky.social · 03/09/2026
A story in three parts
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Brian Fisher @fishparade.bsky.social · 21/08/2026
Is this how we’re gonna get court packing
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Brian Fisher @fishparade.bsky.social · 14/08/2026
R would never
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Brian Fisher @fishparade.bsky.social · 11/06/2026
Can someone at Tecan please let Claude Mythos fix all its software
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Bethany Halford @bethanyhalford.bsky.social · 07/05/2026
Biocatalysts can build big molecules. A team at Merck & Co. developed a suite of enzymes that stitch together their oral PCSK9 inhibitor enlicitide. My latest for @cenmag.bsky.social cen.acs.org/pharmaceutic... #chemsky
Chemical structure of enlicitide
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Alex Ip 葉清霖 @alexip718.com · 26/04/2026
There was a mass shooting this morning at Indiana University that has left nine injured. The Indiana Daily Student has been facing pressure by Republicans and school administrators to shut down the print edition all year. Why isn't Donald Trump or legacy media corps reporting about this huh?
idsnews.com
LIVE UPDATES: At least 5 wounded by bullets, fragments during Kirkwood shooting, no suspects in custody
A press conference is scheduled for 1 p.m. at City Hall.
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Brian Fisher @fishparade.bsky.social · 27/02/2026
I found a cloned Cobalt theme so my brain is fully convinced it’s RStudio still—guess that’s all it takes!
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Brian Fisher @fishparade.bsky.social · 24/02/2026
Uhhh is that psilocybin on the chalkboard?
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Brian Fisher @fishparade.bsky.social · 22/02/2026
Turns out I just needed to make the page wider 🙃
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Brian Fisher @fishparade.bsky.social · 22/02/2026
RStudio has given me enough trouble that I’m finally shopping around for another IDE. It’s tough to say goodbye to all the built-up muscle memory with it, but I can only take so many crashes while I prepare for an important meeting. Positron is seeming fine so far but it’s… just VSCode?
positron.posit.co
Positron
Positron unifies exploration and production work in one free, AI-assisted environment, empowering the full spectrum of data science in Python and R.
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Kaylyn Saucedo - MarzGhoul @marzgurl.com · 27/06/2025
Zohran Mamdani's Socialist Promises:

Oficially enshrine Final Fantasy IX as "The Best One"
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Brian Fisher @fishparade.bsky.social · 10/02/2026
Being a patient in like 7 different vaccine clinical trials did this for me. It’s nice for medicine to be less intimidating!
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Brian Fisher @fishparade.bsky.social · 10/02/2026
This is an Indiana thing?? I had no idea those free Pizza Express breadsticks were a regional delicacy
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Brian Fisher @fishparade.bsky.social · 03/02/2026
I love plotly, it works so well with Quarto! And putting plotly things next to ggplot graphics always gives me the result I want!!!!!
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Brian Fisher @fishparade.bsky.social · 03/02/2026
Damn, good thing I never update it
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Brian Fisher @fishparade.bsky.social · 20/01/2026
IU!!!!!!!
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Adam Kucharski @adamjkucharski.bsky.social · 13/01/2026
Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version? I made an app you might like: adamkucharski.github.io/pdf2plot/ It all started a few years ago... 🧵
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Brian Fisher @fishparade.bsky.social · 30/12/2025
Love it when a developer of a tool I use almost daily just up and decides the input files are -f and not -i anymore
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Brian Fisher @fishparade.bsky.social · 23/12/2025
Honestly wild that 2.5 million lives saved is the most contrarian number that Ioannidis managed to pull out of his random number generator. ONLY that many?!
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Brian Fisher @fishparade.bsky.social · 09/12/2025
Finally
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Angie Rasmussen @angierasmussen.bsky.social · 08/12/2025
It’s nuts, and Yan Li-Meng is broken, but she bears responsibility for the path she chose to venture down.
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Veronika Kivenson @kivenson.bsky.social · 23/11/2025
New paper out: An archaeal genetic code with all TAG codons as pyrrolysine: www.science.org/doi/10.1126/...
science.org
An archaeal genetic code with all TAG codons as pyrrolysine
Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...
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Brian Fisher @fishparade.bsky.social · 21/10/2025
4 x 4L bottle boxes are the GOAT of moving
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Scott Bagley @bagphos.bsky.social · 27/09/2025
This is such a neat idea from the @narayanlab.bsky.social and the @hartwiggroup.bsky.social now in #JACSasap fooling enzymes with a removable binding ligand to accept non-native substrates #ChemSky
pubs.acs.org
Site-, Stereo-, and Chemoselective Enzymatic Halogenation of Terpenoids by a Substrate Masquerade
Enzymatic halogenation of C–H bonds is a promising approach to synthesize chlorine-containing compounds. However, few halogenases chlorinate C(sp3)–H bonds of molecules lacking a carrier protein, and ...
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Brian Fisher @fishparade.bsky.social · 16/09/2025
Larry Tesler, inventor of the cut, copy, and paste commands, dies at 74
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Brian Fisher @fishparade.bsky.social · 11/09/2025
The thing I love about taxonomy is that it never changes and everyone agrees on names for everything!!!
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Derek Lowe @dereklowe.bsky.social · 04/09/2025
Do you really need to stir your reactions? How do you know?
science.org
Stirring Bars are Superstition?
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jamelle @jamellebouie.net · 31/08/2025
"oh nothing matters because mr. trump won't let it matter" shut up
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Brian Fisher @fishparade.bsky.social · 29/08/2025
Getting into homeownership is really making me much more of a just-call-customer-service person than I expected
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Brian Fisher @fishparade.bsky.social · 25/08/2025
A lot of people will believe this shit! Lots of suburban and rural folks truly think that US cities are literal war zones. They could easily be convinced that if they visit them and find them pleasant and safe that it was all Trump’s doing rather than them being fine the whole time.
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Brian Fisher @fishparade.bsky.social · 10/08/2025
ACS 1996 is a fine starting point but imo you should probably manually tailor your ChemDraw object settings to whatever kinds of molecules you work most with. I worked with polypeptides through my PhD and I really didn’t like how its skinny bonds made these long molecules look like chicken scratches
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Rafe Meager (they/them) @economeager.bsky.social · 08/08/2025
Oh so it does have phd level intelligence
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Brian Fisher @fishparade.bsky.social · 01/08/2025
Trump take video game
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Brian Fisher @fishparade.bsky.social · 31/07/2025
Hope the estate of Henrietta Lacks is on this
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Brian Fisher @fishparade.bsky.social · 30/07/2025
Baby’s first Nanopore run
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Kristina Killgrove @killgrove.bsky.social · 24/07/2025
The 2010 paper claiming arsenic-based life has been retracted by Science today. 🧪
livescience.com
Embattled 'arsenic life' paper retracted by journal Science 15 years after publication
A controversial 2010 study that suggested bacteria could grow using arsenic instead of phosphorus has been retracted by the research journal Science.
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Brian Fisher @fishparade.bsky.social · 23/07/2025
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Wario64 @wario64.bsky.social · 16/07/2025
Follow @wario64.bsky.social and repost for a chance to win 1 of 15 Steam codes for Dungeons & Dragons Neverwinter Nights 2: Enhanced Edition courtesy of @aspyr.com. Giveaway ends on July 20th, 6 PM PT game is available now on PC and consoles store.steampowered.com/app/2738630/...
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Brian Fisher @fishparade.bsky.social · 17/07/2025
Pedagogy is often worse at more elite institutions, even. Place like Indiana University have faculty that publish in J Chem Ed. More elite institutions just wanna hire more faculty who’ll publish in CNS, their teaching skills be damned.
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Brian Fisher @fishparade.bsky.social · 20/06/2025
Something anybody who’s set up parallel heterogeneous catalysis experiments—or reactions limited by gas transfer rates—has probably run into at some point. Good to see this phenomenon highlighted!
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Brian Fisher @fishparade.bsky.social · 16/06/2025
Even worse is cafes that make their own oat milk. Oatly is good, just buy that! The only two lattes I’ve ever tossed because they were so bad had homemade oat milk.
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Erica Chenoweth @chenoweth.bsky.social · 13/06/2025
My team and I at the Crowd Counting Consortium (@djpressman@bsky.social, Soha Hammam, & Chris Shay) have a new piece out: wagingnonviolence.org/2025/06/amer.... In it, we show that through May 2025, the size and scale of anti-Trump protests have dwarfed those in 2017. 🧵
A line chart with a blue line showing a large growth of protest events from Jan 20 - May 31, 2025, and a green line showing the relatively modest growth of protest events during the same period in 2017.
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Brian Fisher @fishparade.bsky.social · 10/06/2025
Fun times with @nanoporetech.com ahead!
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Brian Fisher @fishparade.bsky.social · 09/06/2025
Loving the new macOS design language
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Doug Mack @douglasmack.bsky.social · 08/06/2025
not the main issue here but i'd really appreciate it if democratic politicians spoke out in support of big-city life and culture with the same energy and reverence that all politicians have for small towns los angeles is "real america" and so are all the other big cities the president hates
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