Sign in

Brian Fisher

@fishparade.bsky.social
393 followers 415 following 275 posts

Enzyme tinkerer, FFIX stan, 10-year ReadCube subscriber

PostsRepliesMedia
Brian Fisher @fishparade.bsky.social · 08/10/2026
A positive transit fact for Houston! Don’t see those every day.
010
Reposted by Brian Fisher
Nobel Prize @nobelprize.org · 07/10/2026
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2026 #NobelPrize in Chemistry to Henri B. Kagan and Kenso Soai “for the discovery of non-linear effects and autocatalysis in asymmetric organic synthesis.”
4397194
Brian Fisher @fishparade.bsky.social · 07/10/2026
The Soai reaction!! All the reading I did about the origins of biological homochirality for a seminar I gave on it 14 years ago is flooding back to me
000
Brian Fisher @fishparade.bsky.social · 10/09/2026
I thought they killed her off
030
Brian Fisher @fishparade.bsky.social · 06/09/2026
Gonna fuck up a lot of databases when NM becomes NA
011
Brian Fisher @fishparade.bsky.social · 04/09/2026
Validation for my just-go-real-fast aseptic technique
010
Brian Fisher @fishparade.bsky.social · 03/09/2026
A story in three parts
010
Brian Fisher @fishparade.bsky.social · 31/08/2026
Makes me really wish my dog wasn’t so reactive to other dogs
140
Brian Fisher @fishparade.bsky.social · 21/08/2026
Is this how we’re gonna get court packing
000
Brian Fisher @fishparade.bsky.social · 19/08/2026
Around March 2020, when the ACS canceled its spring meeting due to the “novel coronavirus”, Cronin was calling everyone cautious about it idiotic cowards because “his models” predicted that the virus would cease spreading soon. Glad this guy stayed over on the Other App.
010
Brian Fisher @fishparade.bsky.social · 14/08/2026
R would never
020
Brian Fisher @fishparade.bsky.social · 17/07/2026
On page 2 of the first book, the protagonist mentions his ex’s cat costing “more than his monthly salary”. On page 3, he uses the exact same phrase. The author couldn’t think of more than one way to describe something as expensive!
1211
Brian Fisher @fishparade.bsky.social · 11/06/2026
Can someone at Tecan please let Claude Mythos fix all its software
020
Brian Fisher @fishparade.bsky.social · 02/06/2026
Oh yeah the movie about what happened when the “dummies” at ACS cancelled their spring 2020 meeting due to hysteria about some novel coronavirus that the main character’s epidemiological models predicted would snuff itself out in a few weeks
040
Reposted by Brian Fisher
Bethany Halford @bethanyhalford.bsky.social · 07/05/2026
Biocatalysts can build big molecules. A team at Merck & Co. developed a suite of enzymes that stitch together their oral PCSK9 inhibitor enlicitide. My latest for @cenmag.bsky.social cen.acs.org/pharmaceutic... #chemsky
Chemical structure of enlicitide
23113
Brian Fisher @fishparade.bsky.social · 27/04/2026
Ubers were insanely cheap at that time—maybe that’s part of it? An Uber Pool from Hyde Park to downtown was cheaper than Metra fare often around 2017
030
Reposted by Brian Fisher
Alex Ip 葉清霖 @alexip718.com · 26/04/2026
There was a mass shooting this morning at Indiana University that has left nine injured. The Indiana Daily Student has been facing pressure by Republicans and school administrators to shut down the print edition all year. Why isn't Donald Trump or legacy media corps reporting about this huh?
idsnews.com
LIVE UPDATES: At least 5 wounded by bullets, fragments during Kirkwood shooting, no suspects in custody
A press conference is scheduled for 1 p.m. at City Hall.
5124691005
Brian Fisher @fishparade.bsky.social · 30/03/2026
Un Caffe in Midtown is great!
010
Brian Fisher @fishparade.bsky.social · 12/03/2026
My favorite a couple years ago was Sticky Gleaves
020
Brian Fisher @fishparade.bsky.social · 27/02/2026
I found a cloned Cobalt theme so my brain is fully convinced it’s RStudio still—guess that’s all it takes!
100
Brian Fisher @fishparade.bsky.social · 24/02/2026
Uhhh is that psilocybin on the chalkboard?
000
Brian Fisher @fishparade.bsky.social · 22/02/2026
Turns out I just needed to make the page wider 🙃
010
Brian Fisher @fishparade.bsky.social · 22/02/2026
RStudio has given me enough trouble that I’m finally shopping around for another IDE. It’s tough to say goodbye to all the built-up muscle memory with it, but I can only take so many crashes while I prepare for an important meeting. Positron is seeming fine so far but it’s… just VSCode?
positron.posit.co
Positron
Positron unifies exploration and production work in one free, AI-assisted environment, empowering the full spectrum of data science in Python and R.
000
Reposted by Brian Fisher
Kaylyn Saucedo - MarzGhoul @marzgurl.com · 27/06/2025
Zohran Mamdani's Socialist Promises:

Oficially enshrine Final Fantasy IX as "The Best One"
751677476
Brian Fisher @fishparade.bsky.social · 10/02/2026
Being a patient in like 7 different vaccine clinical trials did this for me. It’s nice for medicine to be less intimidating!
020
Brian Fisher @fishparade.bsky.social · 10/02/2026
This is an Indiana thing?? I had no idea those free Pizza Express breadsticks were a regional delicacy
031
Brian Fisher @fishparade.bsky.social · 05/02/2026
Not me learning that join_by exists from this post
100
Brian Fisher @fishparade.bsky.social · 03/02/2026
I love plotly, it works so well with Quarto! And putting plotly things next to ggplot graphics always gives me the result I want!!!!!
020
Brian Fisher @fishparade.bsky.social · 03/02/2026
Damn, good thing I never update it
000
Brian Fisher @fishparade.bsky.social · 20/01/2026
IU!!!!!!!
110
Reposted by Brian Fisher
Adam Kucharski @adamjkucharski.bsky.social · 13/01/2026
Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version? I made an app you might like: adamkucharski.github.io/pdf2plot/ It all started a few years ago... 🧵
18479182
Brian Fisher @fishparade.bsky.social · 30/12/2025
Especially when they change the expected format of a .csv file to have headers all of a sudden 🙃
000
Brian Fisher @fishparade.bsky.social · 30/12/2025
Love it when a developer of a tool I use almost daily just up and decides the input files are -f and not -i anymore
100
Brian Fisher @fishparade.bsky.social · 23/12/2025
The existence of this letter was reported a couple years ago: www.nbcnews.com/news/us-news...
nbcnews.com
Jeffrey Epstein tried to send a letter to Larry Nassar before his death, records show
The letter to Nassar, the U.S. gymnastics team doctor convicted of sexually abusing scores of athletes, was found returned to sender in the jail’s mail room weeks after Epstein’s death in August 2019,...
220
Brian Fisher @fishparade.bsky.social · 23/12/2025
Honestly wild that 2.5 million lives saved is the most contrarian number that Ioannidis managed to pull out of his random number generator. ONLY that many?!
000
Brian Fisher @fishparade.bsky.social · 09/12/2025
Finally
100
Reposted by Brian Fisher
Angie Rasmussen @angierasmussen.bsky.social · 08/12/2025
It’s nuts, and Yan Li-Meng is broken, but she bears responsibility for the path she chose to venture down.
68219
Brian Fisher @fishparade.bsky.social · 06/12/2025
Oh this is exactly my father-in-law’s aesthetic, this takes care of my Christmas shopping for him
1130
Brian Fisher @fishparade.bsky.social · 26/11/2025
It’s fine, we still have uhhhh ggvis
000
Reposted by Brian Fisher
Veronika Kivenson @kivenson.bsky.social · 23/11/2025
New paper out: An archaeal genetic code with all TAG codons as pyrrolysine: www.science.org/doi/10.1126/...
science.org
An archaeal genetic code with all TAG codons as pyrrolysine
Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...
16739
Brian Fisher @fishparade.bsky.social · 21/10/2025
4 x 4L bottle boxes are the GOAT of moving
000
Brian Fisher @fishparade.bsky.social · 07/10/2025
Sleeeiiiigh
01012
Brian Fisher @fishparade.bsky.social · 06/10/2025
For Texas residents offended by this, ask yourself: What kind of person wants to move to Texas? Not people who want to move to be closer to family or whatever—people who believe in their hearts that Texas is where they were meant to be?
050
Reposted by Brian Fisher
Scott Bagley @bagphos.bsky.social · 27/09/2025
This is such a neat idea from the @narayanlab.bsky.social and the @hartwiggroup.bsky.social now in #JACSasap fooling enzymes with a removable binding ligand to accept non-native substrates #ChemSky
pubs.acs.org
Site-, Stereo-, and Chemoselective Enzymatic Halogenation of Terpenoids by a Substrate Masquerade
Enzymatic halogenation of C–H bonds is a promising approach to synthesize chlorine-containing compounds. However, few halogenases chlorinate C(sp3)–H bonds of molecules lacking a carrier protein, and ...
1194
Brian Fisher @fishparade.bsky.social · 25/09/2025
Universal Basic Jackass
0100
Brian Fisher @fishparade.bsky.social · 22/09/2025
Tylenol’s gotta be in blister packs
040
Brian Fisher @fishparade.bsky.social · 16/09/2025
Larry Tesler, inventor of the cut, copy, and paste commands, dies at 74
010
Brian Fisher @fishparade.bsky.social · 11/09/2025
The thing I love about taxonomy is that it never changes and everyone agrees on names for everything!!!
000
Brian Fisher @fishparade.bsky.social · 06/09/2025
Wish I owned the copyright to all the papers of mine used by them…
020
Reposted by Brian Fisher
Derek Lowe @dereklowe.bsky.social · 04/09/2025
Do you really need to stir your reactions? How do you know?
science.org
Stirring Bars are Superstition?
175711