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Federico Gaiti

@fgaiti.bsky.social
229 followers 524 following 13 posts

Cancer Researcher at Princess Margaret Cancer Centre, Assistant Professor at U of T

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Federico Gaiti @fgaiti.bsky.social · 11/06/2026
Thanks to Diane Krause and the editors for the opportunity, and to the other authors @alejofraticelli.bsky.social @shalinhnaik.bsky.social in the clonal tracking series: doi.org/10.1182/bloo... We also recorded a podcast together—well worth a listen! bloodpodcast.transistor.fm/episodes/rev...
doi.org
Introduction to a review series on clonal tracking in hematopoiesis
Over the past decade, advances in single-cell genomics, lineage tracing, and computational phylogenetics have transformed our understanding of hematopoiesi
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Federico Gaiti @fgaiti.bsky.social · 11/06/2026
Happy to share our new review in Blood, led by Jiaoyi Chen & Benson Wu! We explore how DNA methylation can help retrace a cancer’s history and reveal how tumours evolve and respond to treatment. www.sciencedirect.com/science/arti...
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Reposted by Federico Gaiti
Terry Fox Research Institute (TFRI) @terryfoxresearch.bsky.social · 12/12/2025
Terry Fox Research Institute Year in Review: February 2025 TFRI awarded $2.6M to future leaders advancing research in melanoma, lung, brain, blood, and pediatric cancers and driving progress in detection, metastasis, drugs, immunotherapy and precision medicine. Learn more: tinyurl.com/mv5sw6kz
Graphic titled, "Terry Fox Research Institute Year in Review." Features photos of the 5 awardees. Subtitle, "$2.6 million for the 2025 Terry Fox New Investigator Awardees"
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Federico Gaiti @fgaiti.bsky.social · 17/10/2025
Really excited to be part of this initiative! Huge thanks to @braincanada.bsky.social & @src-crs.bsky.social for investing in brain cancer research and supporting the great work of these two amazing teams! @pmresearch-uhn.bsky.social @uhnresearch.ca
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Reposted by Federico Gaiti
Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 31/07/2025
🇨🇦🇦🇺 Thank you to @garvaninstitute.bsky.social for joining us at the Allan Slaight Breakthrough Forum! Scientists were brought together to tackle tumour complexity for translational impact. Together, we’re accelerating the path toward more precise and effective cancer care.💙
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Reposted by Federico Gaiti
Canadian Cancer Society Research @ccsresearch.bsky.social · 18/07/2025
Weekly #cancerresearch highlight: @fgaiti.bsky.social and his team are pinpointing mutations that signal lymphoma, aiming to intercept this #cancer before it develops. This could significantly improve the chances of successful treatment for those at higher risk. Learn more: is.gd/djdklR
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Federico Gaiti @fgaiti.bsky.social · 16/05/2025
Grazie mille Mario!
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Federico Gaiti @fgaiti.bsky.social · 16/05/2025
#Glioblastoma #CancerNeuroscience #Epigenomics #SingleCell #BrainTumor #DevCell
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Federico Gaiti @fgaiti.bsky.social · 16/05/2025
📖 Read here: www.sciencedirect.com/science/arti...
sciencedirect.com
Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration
Glioblastoma (GBM) is an aggressive brain tumor with a highly invasive nature. Despite the clinical relevance of this behavior, the molecular underpin…
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Federico Gaiti @fgaiti.bsky.social · 16/05/2025
Proud to contribute to the field of #CancerNeuroscience, building on the foundational work of leaders and pioneers in the field!
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Federico Gaiti @fgaiti.bsky.social · 16/05/2025
🙏 Huge thanks to our incredible collaborators @uhn.ca @uhnresearch.ca @pmresearch-uhn.bsky.social , the patients & families, and our funders @CIHR @NSERC @pmresearch-uhn.bsky.social @theabta.bsky.social @oicr.on.ca @braincanada.bsky.social @src-crs.bsky.social @terryfoxresearch.bsky.social
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Federico Gaiti @fgaiti.bsky.social · 16/05/2025
💡 What’s next? Can we target these epigenetically sustained cell states or disrupt tumor-neuron crosstalk to limit recurrence?
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Federico Gaiti @fgaiti.bsky.social · 16/05/2025
➡️ Our findings provide insights into the neurodevelopmental hijacking that drives GBM infiltration in patients, revealing how tumor cells mimic brain development to invade.
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Federico Gaiti @fgaiti.bsky.social · 16/05/2025
We found that: 🧬 Infiltrating GBM cells adopt an uncommitted oligodendrocyte progenitor-like state ⚡ They engage in synaptic signaling and neuron-tumor crosstalk 🧠 This state is epigenetically regulated and sustained by developmental transcription factors such as ZEB1, and others
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Federico Gaiti @fgaiti.bsky.social · 16/05/2025
We performed single-cell and spatial profiling of infiltrating GBM cells directly from human patients, moving beyond preclinical models to reveal how these cells behave at the invasive edge in the human brain.
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Federico Gaiti @fgaiti.bsky.social · 16/05/2025
Excited to share our first lab paper, now published in Developmental Cell @cellpress.bsky.social ! 🧠 How do glioblastoma (GBM) cells invade the brain, and what enables them to spread so effectively?
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Reposted by Federico Gaiti
Research at UHN @uhnresearch.ca · 28/02/2025
Congratulations to @pmresearch-uhn.bsky.social's Dr. Federico Gaiti, who was awarded the Terry Fox Research Institute's New Investigator Award, supporting the next generation of #cancer researchers! 🙌
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Reposted by Federico Gaiti
Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 27/02/2025
Congratulations to our scientist Dr. Federico Gaiti who received Terry Fox New Investigator Award from Terry Fox Research Institute. Read more about the award announcement and Dr. Gaiti's research project on understanding the spread of brain tumour: www.tfri.ca/our-research...
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