iiinova — where your digital self keeps evolving

PGC Functional Genomics @fg-pgc.bsky.social · 06/06/2026

Well done to the team🎉, and remember to find the full paper at 🔗bit.ly/4x9c5qx 5/5 🧵

PGC Functional Genomics @fg-pgc.bsky.social · 06/06/2026

🔑Key findings (3/3): ✨Differences in estimated cell composition and the identification of immune-related genes ✨suggests a potential role for immune system processes in OCD. 4/5 🧵

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PGC Functional Genomics @fg-pgc.bsky.social · 06/06/2026

🔑Key findings (2/3): ✨DNA methylation at most loci was influenced by genetic variation (mQTLs), ✨suggesting that epigenetic studies may capture underlying genetic liability of OCD. 3/5 🧵

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PGC Functional Genomics @fg-pgc.bsky.social · 06/06/2026

🔑Key findings (1/3): ✨methylation sites and differentially methylated regions associated with OCD, ✨mapped to genes involved in neurotransmission, neurodevelopment, synaptic function, and gene regulation, ✨sex-specific signals and associations shared across sex 2/5 🧵

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PGC Functional Genomics @fg-pgc.bsky.social · 06/06/2026

🚨Our SECOND new paper alert for today 🚨 ✨Check out the new large OCD-case control EWAS published by @kirahoeffler.bsky.social & colleagues ✨ 🔗bit.ly/4x9c5qx 1/5 🧵

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PGC Functional Genomics @fg-pgc.bsky.social · 06/06/2026

A big congrats to the team🥳, and don't forget to check out the full paper here 🔗bit.ly/4sGX9O6 🧵4/5

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PGC Functional Genomics @fg-pgc.bsky.social · 06/06/2026

🔑Key findings (2/2): 🔷Importantly, polymethylation scores (PMS) improved prediction beyond polygenic scores (PGS), 🔷especially for bipolar I disorder: combined PMS + PGS models explained 18.5% of variance. 🧵4/5

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PGC Functional Genomics @fg-pgc.bsky.social · 06/06/2026

🔑Key findings (1/2): 🔷Shared and sex-specific methylation differences in bipolar disorder, 🔷with differential methylation mapping to genes 🧬involved in immune regulation😷and neurotransmission🧠 🧵3/5

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PGC Functional Genomics @fg-pgc.bsky.social · 06/06/2026

This was a ✨huge collaborative effort✨ across 12 cohorts👥 that looked at genetic🧬methylation patterns as a window into how🧐genetic risk manifests as BD. 🧵2/5

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PGC Functional Genomics @fg-pgc.bsky.social · 06/06/2026

🚨New paper alert!🚨 The bipolar disorder (BD) meta epigenome-wide association study (EWAS) by Tesfaye & colleagues is Out now in eBioMedicine 🔗bit.ly/4sGX9O6 🧵1/5

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PGC Functional Genomics @fg-pgc.bsky.social · 17/04/2026

A huge congrats to the team🎉 You can find the full article here🔗: doi.org/10.1016/j.bp... #GWAS #SpatialTranscriptomics #schizophrenia #bipolaredisorder

doi.org

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PGC Functional Genomics @fg-pgc.bsky.social · 17/04/2026

Key results🗝️: Common 🧬variant liability to: 1️⃣schizophrenia, bipolar disorder and, to a lesser extent, depression 2️⃣enriched in the subiculum and neuron-rich areas of the cornu ammonis subfields and dentate gyrus🧠. 🧵3/4

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PGC Functional Genomics @fg-pgc.bsky.social · 17/04/2026

Methods🧑🏽‍🔬: ⭐Used gsMAP to test enrichment of SNP heritability ⭐Traits: schizophrenia, bipolar disorder, major depressive disorder ⭐Tissues: 13 hippocampal subregions, based on expression specificity of associated genes using spatial transcriptomic data from the adult hippocampus. 🧵2/4

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PGC Functional Genomics @fg-pgc.bsky.social · 17/04/2026

Hello! We are back with another paper spotlight📃! This paper explores how different subregions of the hippocampus 🧠(the part of the brain🎓 involved in learning and memory💭) mediate the role of genetic🧬 risk factors in psychiatric conditions. 🧵1/4

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PGC Functional Genomics @fg-pgc.bsky.social · 27/02/2026

They underscore that such an approach will grow trust in science, and improve the science itself, by guiding researchers to design🧐studies centred on outcomes most meaningful for those living with psychiatric disorders🫂.

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PGC Functional Genomics @fg-pgc.bsky.social · 27/02/2026

The authors also highlight that the increasing prevalence of mis- and disinformation makes it essential for researchers to facilitate multidirectional engagement with ALL those affected by research, from other scientists🧑🏽‍🔬, to clinicians👩🏽‍⚕️, to those affected and beyond🚀.

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PGC Functional Genomics @fg-pgc.bsky.social · 27/02/2026

The article discusses the importance of multidirectional communication📡in #psychiatricgenetics, the barriers it faces, and the efforts of the PGC to integrate it into psychiatric 🧠genetics research🧬.

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PGC Functional Genomics @fg-pgc.bsky.social · 27/02/2026

Exciting news! The first publication from the @pgcgenetics.bsky.social Outreach Committee has been published 📰😱 "From Genomes to Conversations: Outreach and Engagement in Psychiatric Genetics," published this month in Behaviour Genetics. 🎉 🔗link.springer.com/article/10.1007/s10519-025-10246-w

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