iiinova — where your digital self keeps evolving

Federico Uliana @fedeuliana.bsky.social · 09/04/2026

1) How do we capture the “golden goose” of interaction proteomics-dynamic, context-dependent PPI networks? Faster data acquisition and deep learning are transforming interactomics. Our review in Molecular Omics highlights recent advances and future directions.

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Reposted by Federico Uliana

The Gairdner Foundation @gairdnerawards.bsky.social · 31/03/2026

Congratulations to John R. Yates III, Ruedi Aebersold and Matthias Mann, recipients of the 2026 Canada Gairdner International Award. Prof. Yates: www.gairdner.org/winner/john-... Prof. Aebersold: www.gairdner.org/winner/ruedi... Prof. Mann: www.gairdner.org/winner/matth... #2026GairdnerAwards

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Reposted by Federico Uliana

The EMBO Journal @embojournal.org · 20/10/2025

Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding @dormannlab.bsky.social www.embopress.org/doi/full/10....

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Emanuele Lamberti @elamberti.bsky.social · 20/07/2025

Direct binding of TDP-43 and Tau drives their co-condensation, but suppresses Tau fibril formation and seeding www.biorxiv.org/content/10.1...

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Reposted by Federico Uliana

bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 11/07/2025

Direct binding of TDP-43 and Tau drives their co-condensation, but suppresses Tau fibril formation and seeding www.biorxiv.org/content/10.1101/202…

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Reposted by Federico Uliana

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 09/07/2025

PKA regulates stress granule maturation to allow timely recovery after prolonged starvation www.biorxiv.org/content/10.1101/202…

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Reposted by Federico Uliana

Eliana Bianco @elianabianco.bsky.social · 02/05/2025

Hello Bluesky! 🌤️ We're on the Molecular Cell cover! How are ribosome levels adjusted? Stm1 not only protects ribosomes from degradation, it also promotes their biogenesis in nutrient-rich conditions. Two roles, one protein - tuned by nutrient availability. 🔗 www.cell.com/molecular-ce...

cell.com

Stm1 regulates Ifh1 activity revealing crosstalk between ribosome biogenesis and ribosome dormancy

Ribosome abundance is balanced by production and degradation. Bianco et al. discover that the hibernation factor Stm1 has a dual role in ribosome homeostasis. Stm1 promotes ribosome biogenesis during ...

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Reposted by Federico Uliana

Claudio Iacobucci @claudio-iacobucci.bsky.social · 24/04/2025

🚨Registration for the 13th Symposium on Structural Proteomics is open! Milan, Oct 6–8 | Cutting-edge science and vibrant discussions. ssp2025.squarespace.com Proud to co-organize the SSP in Italy with Andrea Graziadei and Lolita Piersimoni @humantechnopole.bsky.social #ChiesiFarmaceutici #univaq

ssp2025.squarespace.com

13th Symposium on Structural Proteomics, 6-8 October 2025

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Reposted by Federico Uliana

Dormann Lab @dormannlab.bsky.social · 17/02/2025

Interested in the molecular mechanisms of neurodegeneration? 📢 We are looking for a PhD student interested in studying the role of TDP-43 in genome stability and the DNA damage response! Apply via this fantastic PhD Programme until April 3 👇

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Reposted by Federico Uliana

Dormann Lab @dormannlab.bsky.social · 06/02/2025

One more day to apply!

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Federico Uliana @fedeuliana.bsky.social · 30/01/2025

Hi Blueskyers! Excited to share our work in @naturecomms.bsky.social. With the group of Michel Steinmetz(PSI) we combined quantitative XL-MS and biophysics to reveal how Bik1 dynamically rearranges in dilute and phase separated state. www.nature.com/articles/s41... (1/2) #TeamMassSpec#idp#PhaseSep

nature.com

Phase separation of a microtubule plus-end tracking protein into a fluid fractal network - Nature Communications

Here, the authors characterize the structural organization and condensate behavior of the microtubule plus-end tracking protein Bik1, employing SAXS, computational modeling, microscopy, and crosslinki...

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Dormann Lab @dormannlab.bsky.social · 29/01/2025

📢 The Dormann Lab is looking for a PhD student interested in the molecular mechanisms of neurodegeneration and biomolecular condensation! Interested in one of our research projects on disease-linked RNA-binding proteins, such as TDP-43 and FUS? Apply to this fantastic PhD program by February 7 👇

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Reposted by Federico Uliana

PLOS Biology @plosbiology.org · 16/01/2025

Pericentromeric #heterochromatin clusters into chromocenters. @skrutlnize.bsky.social &co use quantitative mass spec to characterize the chromocenter proteome in multiple tissues, identifying a link between satellite DNA-binding proteins & #transposon repression🧪 @plosbiology.org plos.io/4akuNAi

Loss of D1 during embryogenesis triggers transposon expression in adult ovaries. Top: Ovaries from the indicated genotypes (D1 and aubergine mutants and heterozygotes, F1 and F2) were stained with Vasa (green) and DAPI (magenta). Bottom: RNA in situ hybridization against Copia (green) and total polyadenylated mRNA (blue) was performed in ovaries of the indicated genotypes that were also stained for DAPI (magenta). Yellow and black arrowheads indicate undifferentiated germ cells in the aubergine mutant germarium.

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