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Fabian Munder

@fabianmunder.bsky.social
117 followers 289 following 3 posts

Postdoc in the Grinter Lab at Bio21, UoM Antibiotic mechanisms| Cryo-EM | Bacterial pathogens | Membrane proteins

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Reposted by Fabian Munder
Lorne Proteins @lorneproteins.bsky.social · 08/02/2026
S3: Luca Troman-Spirochete flagellar motors rotate in opposite directions; periplasmic flagella are more complex. Treponema denticola. 2 motors, thick and thin flagella. SPA Native flagella isolation w optiprep cushion, inner core, outer sheath, mystery density - modelangelo! 🕵‍♀️ #lorneproteins2026
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Reposted by Fabian Munder
Lorne Proteins @lorneproteins.bsky.social · 08/02/2026
Fabien Munder - New strategies to fight AMR. Bacterial competition via L-type pyocins; targeting (1) BamA EC loop 6, (2) beta-strand 1. Inhibit beta barrel assembly by blocking the BAM barrel lumen. Increase cell permeability - holes in the OM. 👏 (EMReady post-processing) 🤓 #lorneproteins2026
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Fabian Munder @fabianmunder.bsky.social · 22/09/2025
Check out our preprint in which we determine how a class of potent protein antibiotics specifically kill P. aeruginosa without a need to enter the cell. doi.org/10.1101/2025... This is work from my PhD in the lab of @rhyswg.bsky.social and many collaborators who contributed amazing data!
doi.org
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
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Reposted by Fabian Munder
Brett Collins @brettcollins.bsky.social · 20/09/2025
This is an amazing paper led by the Grinter lab on bacterial protein antibiotics called pyocins and the mechanism by which they inhibit the BAM outer membrane complex. @rhyswg.bsky.social, @knottrna.bsky.social, @debnathghosal.bsky.social, @doylemt1.bsky.social, @fabianmunder.bsky.social
biorxiv.org
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
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Reposted by Fabian Munder
Rhys Grinter @rhyswg.bsky.social · 20/09/2025
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
biorxiv.org
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
17037
Reposted by Fabian Munder
Rhys Grinter @rhyswg.bsky.social · 30/05/2025
Why make a cofactor when you can get it for free? Our work, led by @fabianmunder.bsky.social, shows that bacteria from 22 phyla use the high-affinity transporter PqqU to obtain the redox cofactor PQQ from the environment as an alternative to cofactor synthesis. www.science.org/doi/10.1126/...
science.org
High-affinity PQQ import is widespread in Gram-negative bacteria
Diverse bacteria use the high-affinity membrane transport protein PqqU to scavenge the nutrient PQQ from the environment.
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