The angiofibrotic switch refers to the pathological transition from active angiogenesis to fibrosis, a process that contributes to disease progression in retinal and choroidal neovascular diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). This switch marks the replacement of newly formed, fragile blood vessels with fibrotic tissue, ultimately leading to scarring and permanent vision loss. Understanding this process is crucial, as fibrosis res...