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Among patients with ARF, a combined intervention of early in-bed cycling and amino acid supplementation appeared safe but did not improve 6MWD or secondary outcomes during hospitalization or 6-month f...

A New York exhibit of more than 3,000 volumes bills itself as ‘an exercise in radical transparency’ – and a bid for attention

Biomarkers to determine underlying frontotemporal lobar degeneration (FTLD) tau or TAR DNA-binding protein (TDP) pathology during life are needed to advance clinical trials targeting specific FTD pathologies. For this purpose, we developed a new ultrasensitive immunoassay to quantify acetylated tau at lysine 174 (AcTau174) in cerebrospinal fluid (CSF). In a sporadic cohort (n = 513), AcTau174 concentrations were higher in all dementia groups (FTLD-TDP, FTLD-Tau, Alzheimer’s disease (AD), mild cognitive impairment (MCI)-AD and dementia with Lewy bodies (DLB)) compared to controls. The largest increase was observed in the FTLD-TDP group, particularly patients with semantic variant primary progressive aphasia (svPPA) and GRN mutation carriers. Notably, AcTau174 discriminated FTLD-TDP from FTLD-Tau (area under the curve (AUC) = 0.83, 95% confidence interval (CI) = 0.75–0.91) and FTLD-TDP from controls (AUC = 0.95, 95% CI = 0.92–0.99) with high accuracy. This was replicated in independent,

Débats unilatéraux, pas d’international… et patatras : première en 2025, la chaîne de Vincent Bolloré dégringole derrière BFMTV et LCI.

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Multiple sclerosis (MS) is an autoimmune disease in which the immune system attacks myelin, the insulating layer that protects nerve fibers. Without proper insulation, the transmission of signals between neurons is disrupted, leading to impairment of motor function, cognitive abilities, and vision [1]. For years it has been known that almost 100% of people with […]