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Eric Horvitz

@erichorvitz.bsky.social
2.7K followers 165 following 30 posts

Chief Scientific Officer of Microsoft.

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Reposted by Eric Horvitz
Integrated DNA Technologies @idtdna.bsky.social · 09/10/2025
Recently, IDT Scientist Adam Clore helped detect AI-designed protein sequences that could be biosecurity threats. The results of the study, led by @microsoft.com CSO @erichorvitz.bsky.social are now published in @science.org. 💻Read more in @technologyreview.com: idtb.io/3bfxmf
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Reposted by Eric Horvitz
Microsoft Research @msftresearch.bsky.social · 16/10/2025
Paraphrasing a protein is like paraphrasing a sentence—the words change, but the meaning holds. Microsoft scientists applied this concept to toxic proteins, revealing a blind spot in DNA screening and leading a cross-sector team to develop a fix. msft.it/6010s4tW8
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Eric Horvitz @erichorvitz.bsky.social · 09/10/2025
We enjoyed working with Adam Clore and his colleagues at @idtdna.bsky.social
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Eric Horvitz @erichorvitz.bsky.social · 09/10/2025
Call for moonshots. First phase: abstracts due on Oct 25, 2025. moonshots.laude.org/call-for-pro...
moonshots.laude.org
Call for Proposals // Laude Moonshots
Laude Moonshots support computer science researchers taking big, urgent swings in AI
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Eric Horvitz @erichorvitz.bsky.social · 06/10/2025
How do we decide what not to share? I explore “information hazards” in this blog--on when openness in science risks misuse. Paraphrase effort led to a first-of-its-kind publishing model, accepted by Science: "When AI Meets Biology" aka.ms/AAy56z3 Full paper on the project avail here: aka.ms/AAy5e9c
aka.ms
The Paraphrase Project
Strengthening nucleic acid biosecurity screening against generative protein design tools — improving hazard detection in the age of AI-assisted protein engineering.
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Eric Horvitz @erichorvitz.bsky.social · 06/10/2025
Background and resources on the Paraphrase Project, published in Science last week, with some of the behind-the-scenes story, my blog on the disclosure dilemma, and a conversation with Bruce Wittman, Tessa Alexanian, and James Diggans. @msftresearch.bsky.social Full paper at: aka.ms/AAy5e9c
aka.ms
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Reposted by Eric Horvitz
Besmira Nushi @besmiranushi.bsky.social · 12/09/2025
Federal research funding works. It’s not an expense–it’s an investment. It’s not overhead–it’s a down payment on the future. - Eric Horvitz, Margaret Martonosi, Moshe Y. Vardi, and James Larus in CACM cacm.acm.org/opinion/keep... @erichorvitz.bsky.social
cacm.acm.org
Keeping the Dream Alive: The Power and Promise of Federally Funded Research – Communications of the ACM
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Eric Horvitz @erichorvitz.bsky.social · 10/06/2025
Study on clinician-AI collaboration: "As LLMs now demonstrate expert-level diagnostic performance, the focus shifts from whether AI can offer valuable suggestions to how it can be effectively integrated into the diagnostic workflow..." Many opportunities ahead. www.medrxiv.org/content/10.1...
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Eric Horvitz @erichorvitz.bsky.social · 02/06/2025
I’m looking forward to the 2025 RAISE Health Symposium at Stanford University, hosted by @stanfordmedicine.bsky.social and the @stanfordhai.bsky.social. Symposium explores the today's health AI, what’s coming next, and directions forward. More here: med.stanford.edu/raisehealth/...
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Eric Horvitz @erichorvitz.bsky.social · 01/06/2025
Conversation with the Computer History Museum on the trajectory of AI through time, on where we are today, and on directions heading into the future. www.youtube.com/watch?v=ddjN... @computerhistory.bsky.social
youtube.com
Chatbots Decoded Interview: Eric Horvitz
YouTube video by Computer History Museum
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Eric Horvitz @erichorvitz.bsky.social · 16/04/2025
Code avail for paper, "Improving Instruction-Following in Language Models through Activation Steering" at #ICLR2025. Exciting to see influence of computed vectors across models. Paper: arxiv.org/abs/2410.12877 Repo: github.com/microsoft/ll... @alestolfo.bsky.social @besmiranushi.bsky.social
arxiv.org
Improving Instruction-Following in Language Models through Activation Steering
The ability to follow instructions is crucial for numerous real-world applications of language models. In pursuit of deeper insights and more powerful capabilities, we derive instruction-specific vect...
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Eric Horvitz @erichorvitz.bsky.social · 08/04/2025
The 2025 AI Index report has been published. Summary & link to full report here: hai.stanford.edu/news/ai-inde... @stanfordhai.bsky.social #AI100
hai.stanford.edu
AI Index 2025: State of AI in 10 Charts | Stanford HAI
Small models get better, regulation moves to the states, and more.
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Eric Horvitz @erichorvitz.bsky.social · 05/03/2025
www.mccormick.northwestern.edu/news/article...
mccormick.northwestern.edu
What AI Means for the Future of Work
On February 18, the Center for Human-Computer Interaction + Design hosted a thought leader panel to discuss the National Academies of Sciences’s
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Reposted by Eric Horvitz
Samuel Sledzieski @samsl.io · 03/03/2025
Seq2Symm is out now in @naturecomms.bsky.social! PLMs continue to be unreasonably efficient-- even for highly divergent sequences. Meghana and Minkyung did a great job leading on this! 📄: www.nature.com/articles/s41... 💻: github.com/microsoft/se...
nature.com
Rapid and accurate prediction of protein homo-oligomer symmetry using Seq2Symm - Nature Communications
Seq2Symm is a sequence-based AI model designed to predict the symmetry of protein structures composed of identical chains, known as homo-oligomers. It surpasses existing methods in accuracy and effici...
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Eric Horvitz @erichorvitz.bsky.social · 03/03/2025
Just released: Report of the 2025 AAAI Presidential Panel on the Future of AI Research. Covers a selection of topics of a larger set of research directions, providing high-level glimpses. Enjoyed collaborating with colleagues on the project. Report pdf avail here: aaai.org/wp-content/u...
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Eric Horvitz @erichorvitz.bsky.social · 03/03/2025
aaai.org/wp-content/u... Willl repost.
aaai.org
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Eric Horvitz @erichorvitz.bsky.social · 03/03/2025
Background on our quantum computing announcement this week on progress on developing a topologically protected qubit: Here's an open version of my LinkedIn article on the nearly two-decade--long project: aka.ms/quantum_brea...
t.co
https://aka.ms/quantum_breakthrough
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Eric Horvitz @erichorvitz.bsky.social · 03/03/2025
MedHELM announced: Popular benchmarks for medical challenge problems have become saturated w/ high perf. of LLMs. New set of benchmarks for evaluating performance LLMs in medicine. 31 datasets, clinically relevant tasks covering 22 subcategories. Leaderboard: lnkd.in/gZ7CkNqc Blog: lnkd.in/gsVQUc2P
lnkd.in
Holistic Evaluation of Language Models (HELM)
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Eric Horvitz @erichorvitz.bsky.social · 03/03/2025
Meeting at Asilomar 50 yrs after 1975 meeting. New issues today with fast-paced advances of AI & biology--and timeless pursuit of questions & directions on the responsibilities of scientific community. Important conversations in a beautiful setting. NPR coverage: www.npr.org/2025/02/25/n...
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Eric Horvitz @erichorvitz.bsky.social · 03/03/2025
Great way to catch up with colleagues on the latest innovations in AI: Poster sessions! At annual meeting of the Association for the Advancement of Artificial Intelligence (AAAI) in Philadelphia.
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Eric Horvitz @erichorvitz.bsky.social · 03/03/2025
When science & technology transcend politics: At Senate Committee hearing, Senators Maria Cantwell & Ted Cruz joined hands to showcase Microsoft’s new quantum chip that leverages discoveries at the frontiers of physics. A striking bipartisan moment. More on quantum effort: aka.ms/quantum_brea...
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Eric Horvitz @erichorvitz.bsky.social · 03/01/2025
Top of the the year reflection. www.politico.com/sponsored/20...
politico.com
Sponsored Content: Harnessing the Power and Potential of AI
How the U.S. can unlock the promise of AI while balancing innovation and responsibility
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Eric Horvitz @erichorvitz.bsky.social · 20/12/2024
Recent results on performance of 01-preview model on medical diagnosis & management challenges arxiv.org/abs/2412.10849 For additional reflections, see article on LinkedIn: www.linkedin.com/pulse/advanc...
arxiv.org
Superhuman performance of a large language model on the reasoning tasks of a physician
Performance of large language models (LLMs) on medical tasks has traditionally been evaluated using multiple choice question benchmarks. However, such benchmarks are highly constrained, saturated with...
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Eric Horvitz @erichorvitz.bsky.social · 14/12/2024
Surprising scene: Jug of spilled milk in front of exhibition hall at NeurIPS meeting. Great catching up with John Platt as the anomalous event unfolded. We both had our assistants at the ready.
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Reposted by Eric Horvitz
Frank Noe @franknoe.bsky.social · 06/12/2024
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science. www.biorxiv.org/content/10.1...
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Eric Horvitz @erichorvitz.bsky.social · 13/12/2024
Perspective article in Cell, "How to build the virtual cell with artificial intelligence: Priorities and opportunities." Enjoyed the collaboration with fabulous colleagues on this perspective piece: www.cell.com/cell/fulltex...
cell.com
How to build the virtual cell with artificial intelligence: Priorities and opportunities
Advances in AI and omics enable the creation of AI virtual cells (AIVCs)—multi-scale, multimodal neural network models that simulate molecules, cells, and tissues across diverse states. This vision outlines their design and collaborative development, promising to transform biological research through high-fidelity simulations, accelerating discoveries, and fostering interdisciplinary open science collaborations.
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Eric Horvitz @erichorvitz.bsky.social · 05/12/2024
Identifying & mitigating an AI-enabled biosecurity vulnerability. Confidential effort on biosecurity red-teaming leads to distrib. of "patches" that bolster DNA synthesis screening. Article: aka.ms/AAtoa8e Work continues. @msftresearch.bsky.social
aka.ms
Toward AI-Resilient Screening of Nucleic Acid Synthesis Orders: Process, Results, and Recommendations
Fast-moving advances in AI-assisted protein engineering are enabling breakthroughs in the life sciences that promise numerous beneficial applications. At the same time, these new capabilities are crea...
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Eric Horvitz @erichorvitz.bsky.social · 03/12/2024
Processes for seeking mutual understanding or “grounding,” adapted from psychology, are important in designs for agentic AI systems, per their complexity & potential high stakes of actions taken on behalf of users. New position paper with colleagues: tinyurl.com/mr2jr2rx @msftresearch.bsky.social
tinyurl.com
Challenges in Human-Agent Communication - Microsoft Research
Explore key challenges in human-agent communication with generative AI and autonomous agents. Learn about transparency, control, and challenges for improving human-AI interaction.
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Eric Horvitz @erichorvitz.bsky.social · 03/12/2024
The Pritzker Prize: Honoring groundbreaking contributions at the intersection of AI and the natural sciences and engineering. Learn more and nominate here: datascience.uchicago.edu/research/ai-...
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Eric Horvitz @erichorvitz.bsky.social · 01/12/2024
Co-organizers of inaugural AI-Bioscience Collaborative summit at National Academies. Event brought together int'l leaders in AI & biotechnology to explore bolstering sequence datasets, compute tools, resources, and to discuss key topics, including AI & biosecurity. More here: tinyurl.com/y6nwa5ze
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Eric Horvitz @erichorvitz.bsky.social · 27/11/2024
Bringing a couple of recent thought pieces to BlueSky. What do folks think about these top 10 priorities for AI research, policy, and practice? A recent CACM article from the leads and cofounder of the One Hundred Year Study on AI. cacm.acm.org/opinion/now-...
cacm.acm.org
Now, Later, and Lasting: 10 Priorities for AI Research, Policy, and Practice – Communications of the ACM
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Eric Horvitz @erichorvitz.bsky.social · 27/11/2024
National Academies report on AI and the Future of Work is out. Here's the top-level summary--and access to the full report: nap.nationalacademies.org/resource/276...
nap.nationalacademies.org
Artificial Intelligence and the Future of Work
Artificial Intelligence and the Future of Work
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Eric Horvitz @erichorvitz.bsky.social · 27/11/2024
In our earlier work (arxiv.org/abs/2303.13375) on med benchmarks, we studied potential memorization influences. Recent influences are hard to assess without further study, but we have some evidence that memorization is not a signif source of jumps, e.g., results on a new Japanese medical benchmark.
arxiv.org
Capabilities of GPT-4 on Medical Challenge Problems
Large language models (LLMs) have demonstrated remarkable capabilities in natural language understanding and generation across various domains, including medicine. We present a comprehensive evaluatio...
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Eric Horvitz @erichorvitz.bsky.social · 27/11/2024
Beyond scaling: We examined capabilities of the o1-preview model on medical benchmarks & found that it blasts past the state of the art. Results underscore potential of test-time strategies. See our blog for results, implications, and promising research directions aka.ms/AAtjxrw
aka.ms
Optimizing foundation models from Medprompt o1
Discover how the o1-preview model improves efficiency and performance in medical language tasks, integrating run-time reasoning to surpass traditional benchmarks.
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Eric Horvitz @erichorvitz.bsky.social · 18/11/2024
Details on BiomedParse published. Exciting direction that shows how large-scale, multimodal joint learning & inference can achieve impressive performance across segmentation, detection, and recognition tasks across medical modalities: www.nature.com/articles/s41... #Microsoft #Providence #UW
nature.com
A foundation model for joint segmentation, detection and recognition of biomedical objects across nine modalities - Nature Methods
BiomedParse is a foundation model for image analysis that uses a joint learning approach to jointly conduct segmentation, detection and recognition and offer state-of-the-art performance across a wide...
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