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Reposted by epithelial-barrier.bsky.social

Allergy EAACI @allergy-eaaci.bsky.social · 24/09/2026

A Strong Proposal for the Reasons of Pandemic Increase in Food Allergies Could common food emulsifiers affect intestinal barrier integrity and IgE immune responses? Read the open-access article: doi.org/10.1111/all.70473 @epithelial-barrier.bsky.social #Allergy_journal journalallergy.com

In this new study, SIAF researchers and their international collaborators investigated soy lecithin and DATEM, two widely used emulsifiers found in processed foods, including some peanut butters.

Using human gut-on-a-chip and adult stem cell-derived colon organoid-on-a-chip models, together with human immune cells and mouse models, the researchers found that both emulsifiers:
🔹 Disrupted intestinal epithelial barrier integrity
🔹 Activated pro-inflammatory pathways, including TNF and NF-κB signalling
🔹 Induced local and systemic inflammatory responses
🔹 Stimulated particularly IgEantibody responses

Soy lecithin additionally induced oxidative stress and increased IgE levels in mice, while DATEM enhanced IL-4-induced IgE production in human peripheral blood mononuclear cells.

These findings support the Epithelial Barrier Theory and highlight the need to consider barrier dysfunction and low-grade immune activation when evaluating the biological effects of commonly used food additives. Further studies are needed to determine their long-term effects in humans.

Congratulations to the entire research team on this publication!

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 24/09/2026

Li, S., Tian, W., Zheng, Y. et al. Climate Change-Mediated Temperature Extremes: Effects on the Immune System and Associations with Immune-Related Diseases. Clinic Rev Allerg Immunol 69, 74 (2026). 👉 link.springer.com/article/10.1... epithelialbarriertheory.com #EpithelialBarrierTheory

Climate change exacerbates extreme temperature events, which pose a growing global threat to human health, especially disturbing the immune system and increasing the incidence of immune-related diseases. This review synthesizes the multifaceted links between extreme temperatures and human immune system. Extreme temperatures could activate the neuroendocrine system, trigger the release of cytokines, regulate heat shock proteins (HSPs) and induce epigenetic modifications. The epithelial barrier dysfunction and gut microbiota dysbiosis are involved in the association between extreme temperature and immune system. These immune perturbations increase the risk of allergic diseases, autoimmune disorders and infectious diseases, disproportionately affecting children, elderly, patients with chronic diseases and people living in low-income and geographically vulnerable areas. Noting limitations like insufficient focus on vulnerable groups and static models, this review highlights the urgency of addressing climate-temperature-immunity interactions to guide climate-resilient public health strategies.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 10/09/2026

R. Jiménez-Saiz, S. Iborra, C. Blanco, et al., “ Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases,” 👉 doi.org/10.1111/all.70512. #EpithelialBarrier #Type2Immunity #Allergy #Immunology #Microbiome epithelialbarriertheory.com #EpithelialBarrierTheory

Type 2 (T2) immunity is best known for its role in allergy and eosinophilic inflammation, but it also has important functions in tissue protection, repair, and homeostasis.

At epithelial barriers, T2 responses are closely shaped by interactions between epithelial cells, the immune system, and the microbiome. Barrier damage and microbial dysbiosis are increasingly recognized across a growing spectrum of T2 diseases.

As biologics targeting IL-4, IL-5, IL-13, IL-31, TSLP, and IgE transform treatment, an important question emerges: what are the long-term consequences of suppressing pathways that also contribute to tissue protection and repair?

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 08/09/2026

Zhao, B., Babayev, H., et al., Monosodium Glutamate Induces Cellular Stress, Endoplasmic Reticulum Stress, Mitochondrial Dysfunction, and Cell Death in Intestinal Epithelial Cells. 👉 doi.org/10.1111/all.70007 epithelialbarriertheory.com #EpithelialBarrierTheory @allergy-eaaci.bsky.social

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 05/09/2026

Serhan, N., Abdullah, N.S., Gheziel, N. et al. Maternal stress triggers early-life eczema through fetal mast cell programming. Nature 646, 161–170 (2025). Read the article here: nature.com/articles/s41586-025-09419-8 epithelialbarriertheory.com #EpithelialBarrierTheory

Prenatal stress (PS) is a repeated exposure to aversive situations during pregnancy, including high emotional strain, which is suspected to affect homeostatic systems in infants. Paediatric eczema develops quickly after birth at flexural sites subjected to continuous mechanical constraints1,2. Although epidemiological studies have suggested an association between PS and a higher risk of eczema in children3,4,5,6, no causative biological link has yet been identified. Here we show that eczema at birth originates from molecular dysregulations of neuroimmune circuits in utero, triggered by fluctuations in the maternal hypothalamic–pituitary–adrenal axis. We found that offspring of stressed pregnant dams have dysregulated mast cells and skin-projecting neurons and quickly develop eczema in response to harmless mechanical friction. We demonstrated that PS transiently modulates amniotic fluid corticosterone concentrations, which directly alters the activation program of skin mast cells expressing the glucocorticoid receptor Nr3c1 and the adjacent sensory neurons conveying mechanosensation. Therapeutic normalization of maternal corticosterone concentrations or genetic depletion of Mcpt5+ mast cells during stressed gestation prevents fetal immune dysregulation and protects against eczema development after birth. Our findings support a new model in which early-onset paediatric eczema originates from dysregulations in the fetal immune system, caused by fluctuations in maternal glucocorticoids induced by stress.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 27/08/2026

D'Avino, P., Kim, J., Li, M., et al. Distinct Roles of IL-4, IL-13, and IL-22 in Human Skin Barrier Dysfunction and Atopic Dermatitis. Allergy, 81: 480-497. Read the article here: doi.org/10.1111/all.70060 epithelialbarriertheory.com #EpithelialBarrierTheory

This study reports the distinct effects of IL-4, IL-13, and IL-22 on bio-stabilized human skin with intact barriers and immune cells. IL-4, IL-13, and IL-22 upregulate inflammatory mediators, disrupt skin barrier integrity, and reciprocally modulate IL-4Rα and IL-22Rα1 receptors. Both type 2 cytokine- and IL-22–related genes show limited response to anti-IL-4Rα antibody (dupilumab), revealing complex immune-barrier interactions in atopic dermatitis. ADAM8, A disintegrin and metalloproteinase domain-containing protein 8; ARG1, Arginase 1; BMP7, Bone morphogenetic Protein 7; CCL, Chemokine Ligand; CTSC, Cathepsin C; FLG, Filaggrin; HAS3, hyaluronan synthase 3; HRH1, Histamine H1 receptor; IL, interleukin; KRT, Keratin; LCE1E, Late cornified envelope 1E; NREP, Neuronal regeneration related protein; NRG2, Neuregulin 2; PRECSIT, p53 Regulated carcinoma associated STAT3 activating long intergenic non-protein coding transcript; USH1G, Usher syndrome type 1G.

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Reposted by epithelial-barrier.bsky.social

Swiss Young Immunologists Society @syis-ecr.bsky.social · 22/05/2026

🏆 SYIS Best Publication Award Submission Paolo D'Avino together with colleagues for the first time directly addressed a long-standing question in atopic dermatitis: How do IL-4, IL-13, and IL-22 individually affect the human skin barrier? 👉 onlinelibrary.wiley.com/doi/10.1111/...

onlinelibrary.wiley.com

Distinct Roles of IL‐4, IL‐13, and IL‐22 in Human Skin Barrier Dysfunction and Atopic Dermatitis

This study reports the distinct effects of IL-4, IL-13, and IL-22 on bio-stabilized human skin with intact barriers and immune cells. IL-4, IL-13, and IL-22 upregulate inflammatory mediators, disrupt...

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 19/08/2026

Pat, Y., Yazici, D., Zeyneloglu, C., et al. Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by #Aspartame. Allergy, 81: 884-901. Read the article here: doi.org/10.1111/all.70095 epithelialbarriertheory.com #EpithelialBarrierTheory

This study shows that #aspartame, at dietary-relevant doses, induces cytotoxicity, cellular distress associated with endoplasmic reticulum stress, oxidative stress, DNA replication and repair mechanism disturbance culminating in epithelial barrier damage. Aspartame triggers NF-κB activation via induction of oxidative stress, leading to proinflammatory cytokine and chemokine release. Aspartame metabolites synergistically contribute to cytotoxicity, oxidative stress and epithelial barrier disruption.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 10/08/2026

D. Yazici, Y. Hayashi, Y. Pat, et al., “ Common Food Emulsifiers Impair Epithelial Barrier Integrity and Trigger Pro-Inflammatory Responses and IgE Production,” 👉 doi.org/10.1111/all.70473 epithelialbarriertheory.com @gmfhx.bsky.social #EpithelialBarrierTheory #Foodadditives #Emulsifiers

Soy lecithin and DATEM, the two commonly used food emulsifiers introduced into many foods including peanut butter and puffed bread, in the 2000s, impair intestinal epithelial barrier integrity in human gut-on-a-chip and induced pluripotent stem cell colon organoid models. Both emulsifiers activate NF-κB/TNF-driven inflammatory pathways and induce stress responses and apoptosis in epithelial cells, with soy lecithin additionally triggering oxidative stress and suppressing aryl hydrocarbon signaling in gut epithelial cells. Oral exposure to emulsifiers within the range of daily doses induces local gastrointestinal and systemic inflammatory responses in mice and increases IgE and IgG responses, suggesting a role in the development of allergies. AhR, aryl hydrocarbon receptor; CCL, chemokine C-C motif ligand; CTLA4, cytotoxic T-lymphocyte associated protein 4; Ctrl, control; CXCL2, C-X-C motif chemokine ligand; DATEM, diacetyl tartaric acid ester of mono- and diglycerides; FOXO1, forkhead box protein O1; Ig, immunoglobulin; NF-κB, nuclear factor kappa B; PPP1R2, phosphatase inhibitor 2; PRDX5, peroxiredoxin-5; RNAseq, RNA sequencing; SNAP29, synaptosomal-associated protein 29; TER, transepithelial electrical resistance; TGF, transforming growth factor; TNF, tumor necrosis factor; TNFRSF11B, osteoprotegerin.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 07/08/2026

Ryczaj K, Beken B, Akdis C. Feeding the Skin Barrier: The Impact of Macro- and Micronutrients on Skin Barrier Function. Clin Transl Allergy. 2025;e70105. Read the article here: doi.org/10.1002/clt2.70105 epithelialbarriertheory.com #EpithelialBarrierTheory

A growing body of evidence underscores the critical relationship between diet and skin barrier function. Nutrient deficiencies highlight the indispensable role of micro- and macronutrients, as well as other dietary constituents, in maintaining the structural and functional integrity of the skin. A nutritionally balanced diet, enriched with components that support keratinocyte differentiation, the cornified envelope, skin lipid synthesis, pH homeostasis, microbiome balance, collagen biosynthesis, and immune regulation, is paramount for preserving a resilient skin barrier. Conversely, minimizing intake of dietary factors detrimental to skin health is equally essential.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 04/08/2026

Moreira, A., Maesano, I.A., Walusiak-Skorupa, J., et al., Healthy Planet, Healthier People: EAACI's Integrated Planetary Health Strategy for #Asthma, #Allergies and Immune Diseases. doi.org/10.1111/all.70164 epithelialbarriertheory.com #EpithelialBarrierTheory

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 28/07/2026

Haahtela, T., O'Mahony, L., Traidl-Hoffmann, C., et al. #EAACI Guidelines on the Importance of Green Space in Urban Environments for #Allergy and #Asthma Prevention. Allergy, 81: 635-650. Read the article here: doi.org/10.1111/all.70182 epithelialbarriertheory.com #EpithelialBarrierTheory

The allergy and asthma epidemic in urban societies following World War II is mostly caused by changes in the environment, diet and lifestyle. Disconnection of urban populations from the wider environment has reduced the protective factors building up immunological resilience. The European Academy of Allergy and Clinical Immunology (EAACI) guidelines on greenness impact on allergy and asthma follow the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach and provide eight recommendations encouraging greenness exposure to support immune health. Controlled follow-up studies are still scarce, and the strength of evidence is generally low or moderate at best. For primary prevention of allergy and asthma, most of the evidence indicates beneficial effects. Exposure is also useful for secondary prevention. Asthma patients may feel better and need less medication by combining green space exposure with physical activity. During the high-pollen season, effective seasonal medication is necessary for patients with pollen allergy. In urban planning, implementing appropriate green infrastructure and easy access to green space promotes immune health and reduces risks of air pollution and heatwaves. These EAACI guidelines are the first recommendations highlighting the importance of urban green spaces on immune health and call for prioritising innovative research in this field.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 24/07/2026

Bicer C, Zeyneloglu C, Akdis C. Laundry chemicals, the epithelial barrier, and early wheeze. Annals of Allergy, Asthma & Immunology, 136, 5-6. Read the article here: www.annallergy.org/article/S108... epithelialbarriertheory.com #EpithelialBarrierTheory

Atopic conditions such as asthma and childhood wheezing have significantly increased since the 1960s, mirroring rapid changes in environmental exposures (the exposome) caused by modernization, industrialization, and westernization. The “epithelial barrier theory” provides an explanation for this trend, suggesting that increased exposure to harmful substances gradually damages the epithelial barrier and microbiome and causes immune/inflammatory activation thus contributing to chronic inflammatory diseases. Surfactant formulas in detergents, household cleaners, dishwashers, hand sanitizers, disinfectants, toothpastes, and many types of air pollution, microplastics, and food additives can damage epithelial barriers, which is the body’s first line of defense. Once injured, these cells release alarmins, increase barrier permeability, and initiate cascades of inflammation and immune dysfunction and cause microbial dysbiosis, all of which together contribute to allergic and inflammatory diseases. Among these exposures, laundry detergents and softeners contain a complex array of chemical compounds, including surfactants, bleaches, fragrances, and enzymes, that can cause epithelial injury and trigger inflammation in both respiratory and dermatologic systems.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 21/07/2026

Bakirtas, A., Kiykim, A., Baskin, A.K., et al. A Survey on Environmental Protective and Risk Factors and Awareness Related to Epithelial Barrier Integrity, Microbiome and Allergic Diseases. Read the article here: doi.org/10.1111/all.70190 epithelialbarriertheory.com #EpithelialBarrierTheory

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 19/07/2026

Y. Zheng, Y.-c. Li, S.-j. Li, et al., “ Patterns and Clinical Efficacy of Biologics Switching in Patients With Severe #Asthma: A Systematic Review and Meta-Analysis,” Read the article here: doi.org/10.1111/all.70333 epithelialbarriertheory.com #EpithelialBarrierTheory

This meta-analysis included 2292 patients with severe asthma who underwent biologic switching across 23 countries/regions. The most prevalent switching pattern was from mepolizumab to benralizumab, with suboptimal asthma control being the primary reason. Biologic switching is probably a promising strategy for achieving clinical remission and improving T2 biomarkers.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 16/07/2026

Saglam-Metiner P, Calkan-Yildirim E, et al. The Impact of the Exposome on Epithelial Barriers: New Approach Methodologies for Translational Research. pubmed.ncbi.nlm.nih.gov/41979118/ epithelialbarriertheory.com #EpithelialBarrierTheory #EnvironmentalHealth #Organoids #OrganOnChip

Environmental exposures—including air pollution, micro- and nanoplastics, detergents, food additives, and climate-related factors—continuously interact with our epithelial barriers. Understanding how these exposures disrupt barrier integrity is essential for uncovering the origins of allergic and many other chronic inflammatory diseases.

Our new review explores:

🔹 The impact of the exposome on epithelial barrier function

🔹 Cellular and molecular mechanisms of barrier disruption

🔹 Advanced translational models, including organoids and organ-on-a-chip technologies

🔹 New Approach Methodologies (NAMs) for studying barrier biology and environmental health

🔹 Future directions for precision medicine and preventive strategies

This review provides an overview of emerging experimental platforms that are helping bridge basic epithelial barrier research with clinical applications.

📖 Read the review:

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 13/07/2026

Castagnoli R, Votto M, Taietti I, et al. Bridging Rare to Common Diseases: Precision Medicine and the Transforming Landscape of Pediatric Allergy and Immunology. Pediatr Allergy Immunol. 2026; 37:e70407. 👉 doi.org/10.1111/pai.70407 epithelialbarriertheory.com #EpithelialBarrierTheory

$Pediatric immunological and allergic conditions represent a broad spectrum, ranging from highly prevalent polygenic disorders (e.g., food allergy, atopic dermatitis, asthma, and allergic rhinitis) to rarer monogenic primary atopic disorders. The management of these conditions has undergone a paradigm shift in recent years. Moving away from a “one-size-fits-all” approach, precision medicine aims to deliver the right treatment to the right patient at the right time. By integrating clinical phenotypes with molecular endotypes and using specific biomarkers and “Omics” techniques, scientists and clinicians can now employ targeted biological therapies that significantly improve patient outcomes. By identifying early therapeutic windows and specific biomarkers, pediatric specialists can implement personalized interventions that halt the atopic march and mitigate the global burden of chronic allergic diseases. By shifting the focus from symptom management to the neutralization of specific molecular pathways, it is now possible to achieve better disease control, reduce side effects associated with broad-spectrum treatments such as systemic corticosteroids, and improve the quality of life for patients with refractory allergic diseases. This review, generated during a seminar funded by the Clemens von Pirquet Foundation, aims to delineate the “rare to common” pipeline, illustrating how precision medicine tools, including multi-omics, biomarkers, and artificial intelligence methods, can connect mechanistic pathways across the immunological spectrum.$

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 10/07/2026

L. Cecchi, I. Annesi-Maesano, B. Biagioni, et al., “ #EAACI Guidelines on Environmental Science for Allergy and #Asthma —Evidence-Based Recommendations for Prevention and Public Health Action to Mitigate the Impact of Pollen Exposure on Respiratory Allergy,” 👉 doi.org/10.1111/all.70423

Developed using the GRADE methodology, these EAACI guidelines provide evidence-based recommendations on the effectiveness of pollen reduction/avoidance strategies for allergic rhinitis (AR) and asthma, the utility of biomarkers for monitoring pollen-induced asthma and the efficiency of mitigation measures and of public health strategies. Systematic and narrative reviews and health economic analysis support the recommendations. According to GRADE, the certainty of evidence was moderate to very low, therefore conditional recommendations are provided to guide healthcare professionals, patients, and policymakers in developing personalized, preventive, and scalable interventions. Reducing/avoiding exposure to pollen should be recommended to reduce the risk of severe asthma exacerbations. Lung function decrease and exhaled nitric oxide increase may be predictive for pollen-induced asthma exacerbations. Real-time pollen monitoring and pollen concentration-based forecast may be recommended for managing pollen-induced AR and/or asthma. Pollutant information should be included in pollen information systems. Combined forecast (weather, pollen, pollutants) and warning systems might reduce the impact of thunderstorm asthma (TA). Emergency department/asthma-related services should be strengthened during pollen season and in TA. Personalized frameworks covering the types and allergenic potential of pollen, the coaggressors and the vulnerability of each patient are needed in daily practice. The fundamental role of prevention should be further prioritized.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 07/07/2026

C. Venter, J. Beltran, J. Bracchiglione, et al., “Immunonutrition in Early Life: The Role of Complementary Feeding, Dietary Patterns, and Nutritional Exposures on the Health of Young Children—An EAACI Scoping Review,” 👉 doi.org/10.1111/all.70429 epithelialbarriertheory.com #EpithelialBarrierTheory

Complementary feeding research now extends beyond calorie counting, macronutrients, and early allergen introduction to dietary patterns and early life nutrition that supports the microbiome. Evidence supports dietary diversity, timely food allergen introduction, and responsive feeding, while discouraging restrictive practices and ultra-processed foods. Future work should harmonize definitions and investigate plant-based diets, advanced glycation end products, and processed food exposures.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 18/06/2026

T. H. Nguyen, C. Akdis, A. Baccarelli, et al., “Leveraging Artificial Intelligence in #Allergy, #Asthma, and #Immunology With Environmental Exposures,” Allergy (2026): 1–16, Read the article here: doi.org/10.1111/all.70401 epithelialbarriertheory.com #EpithelialBarrierTheory

Artificial intelligence (AI) in environmental health science is revolutionizing data analysis and problem-solving approaches. These technologies facilitate the prediction of environmental exposures and disease outcomes and enable the identification of causal relationships for subsequent hypothesis testing. AI techniques improve pollution research through the analysis of satellite imagery and the modeling of pollutant dispersion, while AI advances chemical safety evaluations in toxicology by examining extensive datasets. AI is instrumental in addressing pressing environmental challenges, including remediation of polluted sites and ensuring equitable healthcare applications to mitigate biases. The expanding availability of large-scale environmental, geospatial, and health outcome databases offers unprecedented opportunities for innovative applications. Their predictive capabilities are essential in disaster management, enabling real-time analysis and optimizing resource deployment amid climate-related crises. AI-driven approaches play a critical role in carbon capture and waste management efforts aimed at reducing environmental impact. Furthermore, AI can elucidate complex relationships between the exposome—defined as the totality of exposures throughout an individual's life—and health outcomes, facilitating preventative strategies. This review examines the capabilities and limitations of AI in environmental health and safety, providing insights into its judicious and effective use for environmental management and healthcare.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 12/06/2026

M. Li, H. Babayev, P. D'Avino, et al., “Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms,” Allergy (2026): 1–12, Read the article here: doi.org/10.1111/all.70390 epithelialbarriertheory.com #EpithelialBarrierTheory

Short-term exposure to SDS rapidly disrupts human skin barrier integrity within minutes, as detected by real-time electrical impedance spectroscopy. SDS-induced barrier dysfunction is driven by oxidative stress, leading to suppression of immune/barrier mediators and activation of stress, lipid remodeling, and epidermal differentiation pathways. Antioxidants (NAC and NAM) effectively reduce ROS, restore barrier function, and mitigate SDS-induced cytotoxicity, highlighting a preventive strategy for surfactant-induced skin damage. Abbreviations: AP-1, transcription factor subunit; AREG, amphiregulin; CST5, cystatin D; EIS, electrical impedance spectroscopy; ER, endoplasmic reticulum; ITGA6, integrin alpha-6; JUN, jun proto-oncogene; NAC, N-acetylcysteine; NAM, nicotinamide; PBS, phosphate-buffered saline; PRDX1, peroxiredoxin 1; ROS, reactive oxygen species; SDS, sodium dodecyl sulfate.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 04/06/2026

S.Ardicli, H.Babayev, L.Chang, et al., “Polyethylene Terephthalate Micro and Nanoplastics Induce Oxidative and Endoplasmic Reticulum Stress, Compromising Intestinal Epithelial Integrity and Viability,” 👉 doi.org/10.1111/all.70291 epithelialbarriertheory.com #EpithelialBarrierTheory

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 01/06/2026

Y.Zheng, Y.Li, C.Zeyneloglu, et al., “Risk and Protective Factors for Infection, Severe Disease, and Mortality in Epidemic Respiratory Viruses,” Allergy81, no. 5 (2026): 1397–1432, Read the article here: doi.org/10.1111/all.70314 epithelialbarriertheory.com #EpithelialBarrierTheory

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 28/05/2026

Lan F, Akdis CA, Zhang L. The Rising Tide of Allergic Rhinitis in China: Driving Innovation Forward. Allergy. 2026 May;81(5):1331-1333. Read the article here: doi.org/10.1111/all.70330 epithelialbarriertheory.com #EpithelialBarrierTheory

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 22/05/2026

Effects of Common Food Additives Kappa-, Iota- and Lambda-Carrageenans on Intestinal Epithelial Cell Activation and Barrier Disruption. Clin Exp Allergy. 2026 Apr 6. Na Sun, Yagiz Pat, Huseyn Babayev, et al. 👉 doi.org/10.1111/cea.70266 #EpithelialBarrierTheory epithelialbarriertheory.com

The present study provides direct evidence for the detrimental effects of kappa-, iota- and lambda-carrageenans on gut epithelial cell activation and barrier integrity. The underlying mechanism of epithelial barrier disruption was largely attributed to the activation of innate immune responses by #carrageenans, resulting in a pro-inflammatory response.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 18/05/2026

Saglam-Metiner P, Calkan-Yildirim E, Dogan B, et al. The Impact of the Exposome on #EpithelialBarriers: New Approach Methodologies for Translational Research. Thorac Res Pract. 2026 May 12;27(3):182-194. Read more: bit.ly/3RdodpX epithelialbarriertheory.com #EpithelialBarrierTheory

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 08/05/2026

L.Klimek, J.Mullol, S.Reitsma, et al., “Correspondence: The First Biosimilar for Biologics in Allergy: CT-P39 (Omlyclo-Omalizumab-Igec) Is Available for Asthma, Chronic Spontaneous #Urticaria, and Chronic #Rhinosinusitis With Nasal Polyps,” Allergy (2026): 1–3, 👉 doi.org/10.1111/all.70366

epithelialbarriertheory.com

#EpithelialBarrierTheory

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 06/05/2026

M.Ameri, R.Ziadlou, S.Traidl, et al., “Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1-Skewed T-Cell Response With Signs of Metabolic Alteration,” Allergy (2026): 1–17, 👉 doi.org/10.1111/all.70377 epithelialbarriertheory.com #EpithelialBarrierTheory @allergy-eaaci.bsky.social

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 03/05/2026

Pat, Y., Yazici, D., et al. Postbiotics and Nicotinamide Utilize Distinct Mechanisms to Improve Skin Barrier Integrity, Inflammation, and Keratinocyte Differentiation 👉 doi.org/10.1111/all.70225 epithelialbarriertheory.com #EpithelialBarrierTheory #publichealth @allergy-eaaci.bsky.social

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 22/04/2026

Ogulur I, Yazici D, Pat Y, et al. Mechanisms of gut epithelial barrier impairment caused by food emulsifiers polysorbate 20 and polysorbate 80. Allergy. 👉 doi.org/10.1111/all.15825 epithelialbarriertheory.com #EpithelialBarrierTheory #MedSky @diecastls.bsky.social @mntryjoseph61.bsky.social

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 10/04/2026

The Hidden Chemistry of Everyday Foods: How Emulsifiers and Additives Affect Your Gut 📺 Watch now: www.youtube.com/watch?v=5eN4... #EpithelialBarrierTheory #MedSky epithelialbarriertheory.com

youtube.com

How to avoid toxic substances, emulsifiers and food additives?

YouTube video by Epithelial Barrier Theory

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 01/04/2026

Open Access: The epithelial barrier theory and its associated diseases. Sun N, Ogulur I, Mitamura Y, et al. 👉 doi.org/10.1111/all.16318 #EpithelialBarrierTheory #MedSky epithelialbarriertheory.com

Epithelial barriers plays a key role in many chronic noncommunicable diseases that have increased in prevalence over the past six decades, particularly since the 2000s. Environmental factors such as pollutants, toxic chemicals, micro and nanoplastic and processed foods damage the barrier, disrupting microbiota–immune interactions. More than 70 diseases have been demonstrated to be linked to epithelial barrier damage. Understanding this link may reveal new preventive and better therapeutic strategies for the management of chronic non-communicable diseases.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 25/03/2026

🧬 Curious about the latest research on the Epithelial Barrier Theory? 🔗 Click here to access the articles: 👉 epithelialbarriertheory.com/original-articles 🧪 #BarrierHealth #EpithelialBarrierTheory #AllergyScience #ChronicInflammation #Microbiome #MedicalResearch

Explore the newest original articles that dive deep into how damage to our skin, lung, and gut barriers may be driving the global rise in allergies, autoimmune disorders, and chronic inflammation.
From environmental triggers like pollution and microplastics to the breakdown of epithelial integrity — these studies are reshaping how we understand health and disease in the 21st century.

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 23/03/2026

🧬 A Theory Explaining The Rising Prevalence of more Than 70 Diseases. What if the sharp rise in allergies, autoimmune diseases, and chronic inflammation over the past decades had one thing in common? 📍 Learn more about the theory: 🔗 epithelialbarriertheory.com #EpithelialBarrierTheory #MedSky

That’s the question Professor Cezmi Akdis asked — and the answer became the Epithelial Barrier Theory.
For over 20 years, scientists observed a troubling trend:
🌍 More asthma, more food allergies, more IBD, even more neurodevelopmental and psychiatric conditions.
And it wasn’t just genetics.
🔬 Research showed that our epithelial barriers — the thin protective linings of the gut, skin, and lungs — were being damaged by modern life:
🧪 Detergents
🌫️ Air pollution
🧼 Emulsifiers
🌍 Microplastics
🍽️ Ultra-processed foods
When these barriers break down, toxins, allergens, and microbes enter freely, causing immune system overactivation and inflammation.
This theory connects the dots between the environment and a wide range of modern diseases — and it’s shifting how we approach prevention, diagnosis, and treatment.

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Reposted by epithelial-barrier.bsky.social

Allergy EAACI @allergy-eaaci.bsky.social · 03/03/2026

📢New Issue! #Environment, #Microbiome and #EpithelialBarriers According to the Epithelial Barrier Theory, disruption of tight junctions by environmental toxins, such as detergents, pollutants, and microplastics, drives the disease pathogenesis of many chronic inflammatory conditions #Allergy_journal

The cover of this issue illustrates this critical interface by depicting the developing microbiome of a child. The artwork highlights the early "window of opportunity" in childhood, during which the development of a diverse microbiome and the maturation of the protective epithelial barriers shape long-term immunological health. Advancing our understanding of these processes is essential for developing novel preventive and therapeutic interventions.
© M Oeggerli (Micronaut) 2022, supported by UHB (Pathology) and Bio-EM Lab, Biozentrum, University Basel.

journalallergy.com

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epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 21/03/2026

🧬 To explain the rise of allergies, autoimmune diseases, and neuropsychiatric diseases? 🌐 Dive into trusted science, expert lectures, and original research — all in one place: 👉 epithelialbarriertheory.com #EpithelialBarrierTheory #Immunology #AllergyResearch #ChronicDisease #MedSky

Welcome to the Epithelial Barrier Theory — a groundbreaking concept connecting modern environmental exposures with diseases affecting billions worldwide.

📌 Learn how pollution, detergents, microplastics, and food additives may be silently damaging our body's barriers — and what that means for global health.

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