iiinova — where your digital self keeps evolving

epithelial mechanics fan club @epimechfc.bsky.social · 3h

Gross, B. J., Soltwedel, J. R., ..., Gomez, C., & Campàs, O. (2025). STRESS, an automated geometrical characterization of deformable particles for in vivo measurements of cell and tissue mechanical stresses. Scientific Reports, 15(1), 28599. #EpithelialMechanics www.nature.com/articles/s41...

010

epithelial mechanics fan club @epimechfc.bsky.social · 06/10/2026

Rawal, S., Keshavanarayana, P., Manoj, D., Khuntia, P., Banerjee, S., ..., Spill, F., & Das, T. (2025). Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode. Nature Cell Biology, 27(10), 1660–1675. #EpithelialMechanics www.nature.com/articles/s41...

060

epithelial mechanics fan club @epimechfc.bsky.social · 05/10/2026

Tanida, S., Fuji, K., Lu, L., Guyomar, T., Lee, B. H., ..., Nonomura, M., & Sano, M. (2025). Predicting organoid morphology through a phase field model: Insights into cell division and lumenal pressure. PLOS Computational Biology, 21(8), e1012090. #EpithelialMechanics doi.org/10.1371/jour...

080

epithelial mechanics fan club @epimechfc.bsky.social · 02/10/2026

Choi, B. J., Chen, Y.-C., & Desplan, C. (2025). Retinal calcium waves coordinate uniform tissue patterning of the Drosophila eye. Science, 390(6775), eady5541. #EpithelialMechanics www.science.org/doi/10.1126/...

0102

epithelial mechanics fan club @epimechfc.bsky.social · 01/10/2026

Lange, Z., Matthäus, F., & Qiu, M. (2025). Vertex models capturing subcellular scales in epithelial tissues. PLOS Computational Biology, 21(5), e1012993. #EpithelialMechanicsReview doi.org/10.1371/jour...

041

epithelial mechanics fan club @epimechfc.bsky.social · 30/09/2026

Hsiao, S., Mukenhirn, M., Werner, C., Honigmann, A., & Krieg, E. (2025). Reconfigurable Microenvironments Uncover Mechano‐Sensing Timescales and Direct Cell Polarity. Advanced Functional Materials, 35(49), e13028. #EpithelialMechanics advanced.onlinelibrary.wiley.com/doi/10.1002/...

0114

epithelial mechanics fan club @epimechfc.bsky.social · 29/09/2026

Bresteau, E., Suva, E. E., Revell, C., Hassan, O. A., Grata, A., Sheridan, J., Mitchell, J., ..., Jensen, O. E., & Mitchell, B. (2025). Apical size reduction by macropinocytosis alleviates tissue crowding. Nature Communications, 16(1), 5338. #EpithelialMechanics www.nature.com/articles/s41...

081

Reposted by epithelial mechanics fan club

epithelial mechanics fan club @epimechfc.bsky.social · 27/09/2026

Can mathematics explain how biological patterns are formed? Alan Turing thought so. Join me, @benswedlund.bsky.social, as we explore his reaction-diffusion theory and how it transformed our understanding of pattern formation and self-organisation.

15426

Reposted by epithelial mechanics fan club

Benjamin Swedlund @benswedlund.bsky.social · 28/09/2026

Check out my latest thread for @epimechfc.bsky.social and dive into how a 70 yr old mathematical theory may explain pattern self-organisation in biology!

0163

Reposted by epithelial mechanics fan club

Mark Peifer (He, him) @peiferlabunc.bsky.social · 27/09/2026

Lovely thread about how this decades old theory continues to help us understand developmental pattern 🧪

0204

epithelial mechanics fan club @epimechfc.bsky.social · 27/09/2026

Can mathematics explain how biological patterns are formed? Alan Turing thought so. Join me, @benswedlund.bsky.social , as we explore his reaction-diffusion theory and how it transformed our understanding of pattern formation and self-organisation.

0149

epithelial mechanics fan club @epimechfc.bsky.social · 27/09/2026

As in natural systems, synthetic reaction-diffusion systems can be coupled with other patterning mechanisms, such as differential adhesion, to generate more robust patterns. doi.org/10.64898/202...

130

epithelial mechanics fan club @epimechfc.bsky.social · 27/09/2026

But are these remarkably simple circuits really sufficient to generate patterns in living cells? I tested this by engineering minimal two-component synthetic reaction-diffusion circuits in mammalian fibroblasts and… they self-organised beautiful patterns. doi.org/10.64898/202...

171

epithelial mechanics fan club @epimechfc.bsky.social · 27/09/2026

But how do we identify reaction-diffusion circuits within complex biological networks? We need to know what to look for. Computational screening of thousands of circuit architectures helps us identify the designs that have the ability to generate patterns. doi.org/10.1016/j.ce...

110

epithelial mechanics fan club @epimechfc.bsky.social · 27/09/2026

Beyond embryonic development, self-organised reaction-diffusion-type mechanisms may also contribute to pattern formation in adult tissues, and even during disease progression. doi.org/10.1016/j.ce...

210

epithelial mechanics fan club @epimechfc.bsky.social · 27/09/2026

Of course, biology is not purely self-organised, as embryonic development is a precise sequence of inter-dependent patterning events. Positional information, encoded in the form of morphogen gradients, can orient and constrain self-organised patterning. doi.org/10.1242/dev....

100

epithelial mechanics fan club @epimechfc.bsky.social · 27/09/2026

Models are useful because they can make predictions. Alterations in Turing systems are predicted to change the spacing (wavelength) of the pattern – and that has been observed during digit formation, another reaction-diffusion-mediated patterning event. doi.org/10.1126/scie...

120

epithelial mechanics fan club @epimechfc.bsky.social · 27/09/2026

Over the past two decades, researchers have identified the molecular components of reaction-diffusion systems underlying various periodic patterning events, including the formation of feather buds, hair follicles, and fingerprints. doi.org/10.1016/j.ce...

110

epithelial mechanics fan club @epimechfc.bsky.social · 27/09/2026

What is remarkable is how unreasonably good these equations are at reproducing the incredible diversity of animal skin patterns. But mechanistically, does nature actually work this way? doi.org/10.1146/annu...

110

epithelial mechanics fan club @epimechfc.bsky.social · 27/09/2026

In his seminal 1952 theoretical paper, Alan Turing proposed that partial differential equations, representing molecules (“morphogens”) that react with one another and diffuse through space, can encode spontaneous periodic pattern formation. doi.org/10.1098/rstb...

141

epithelial mechanics fan club @epimechfc.bsky.social · 27/09/2026

15426

epithelial mechanics fan club @epimechfc.bsky.social · 25/09/2026

Toda, S., Guan, G., Tambo, M., Morita, H., & Lim, W. A. (2026). Coupling Mechanical Regulation with Biochemical Reaction-Diffusion Circuits Yields Robust Self-Organized Pattern Formation. Synthetic Biology. #EpithelialMechanics doi.org/10.64898/202...

0103

epithelial mechanics fan club @epimechfc.bsky.social · 25/09/2026

Scholes, N. S., Schnoerr, D., Isalan, M., & Stumpf, M. P. H. (2019). A Comprehensive Network Atlas Reveals That Turing Patterns Are Common but Not Robust. Cell Systems, 9(3), 243–257.e4. #EpithelialMechanics doi.org/10.1016/j.ce...

030

epithelial mechanics fan club @epimechfc.bsky.social · 24/09/2026

Ramos, R., Swedlund, B., Ganesan, A. K., Morsut, L., Maini, P. K., Monuki, E. S., ..., Chuong, C.-M., & Plikus, M. V. (2024). Parsing patterns: Emerging roles of tissue self-organization in health and disease. Cell, 187(13), 3165–3186. #EpithelialMechanicsReview doi.org/10.1016/j.ce...

082

epithelial mechanics fan club @epimechfc.bsky.social · 24/09/2026

Green, J. B. A., & Sharpe, J. (2015). Positional information and reaction-diffusion: two big ideas in developmental biology combine. Development, 142(7), 1203–1211. #EpithelialMechanics doi.org/10.1242/dev....

071

epithelial mechanics fan club @epimechfc.bsky.social · 23/09/2026

Glover, J. D., Sudderick, Z. R., Shih, B. B.-J., Batho-Samblas, C., Charlton, L., Krause, A. L., ..., Crichton, M. L., & Headon, D. J. (2023). The developmental basis of fingerprint pattern formation and variation. Cell, 186(5), 940–956.e20. #EpithelialMechanics doi.org/10.1016/j.ce...

062

epithelial mechanics fan club @epimechfc.bsky.social · 23/09/2026

Swedlund, B., Danan, J. J., Jiang, T.-X., Ben Tahar, S., Poon, K., ..., Ehrenreich, I. M., & Morsut, L. (2026). A novel reaction-diffusion architecture for engineering self-organized patterns in mammalian cells. Synthetic Biology. #EpithelialMechanics doi.org/10.64898/202...

0123

epithelial mechanics fan club @epimechfc.bsky.social · 23/09/2026

Turing, A. M. (1952). The chemical basis of morphogenesis. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 237(641), 37–72. #EpithelialMechanics doi.org/10.1098/rstb...

080

epithelial mechanics fan club @epimechfc.bsky.social · 22/09/2026

Sheth, R., Marcon, L., Bastida, M. F., Junco, M., Quintana, L., Dahn, R., Kmita, M., Sharpe, J., & Ros, M. A. (2012). Hox Genes Regulate Digit Patterning by Controlling the Wavelength of a Turing-Type Mechanism. Science, 338(6113), 1476–1480. #EpithelialMechanics www.science.org/doi/10.1126/...

science.org

Hox Genes Regulate Digit Patterning by Controlling the Wavelength of a Turing-Type Mechanism

Mouse genetics and computer modeling suggest that a reaction-diffusion mechanism defines digit pattern.

0102

epithelial mechanics fan club @epimechfc.bsky.social · 21/09/2026

Milinkovitch, M. C., Jahanbakhsh, E., & Zakany, S. (2023). The Unreasonable Effectiveness of Reaction Diffusion in Vertebrate Skin Color Patterning. Annual Review of Cell and Developmental Biology, 39(1), 145–174. #EpithelialMechanicsReview www.annualreviews.org/content/jour...

0174

epithelial mechanics fan club @epimechfc.bsky.social · 18/09/2026

Panda, Y. A., & Fischer-Friedrich, E. (2026). Localized actin cortex perturbation generates cell-scale membrane tension gradients. Biophysics. #EpithelialMechanics doi.org/10.64898/202...

042

epithelial mechanics fan club @epimechfc.bsky.social · 17/09/2026

Cao, J., Chiappori, A., Landiech, S., Clément, R., & Lenne, P.-F. (2026). A developmental biologist's guide to mechanics. Development, 153(16), dev205785. #EpithelialMechanicsReview doi.org/10.1242/dev....

061

epithelial mechanics fan club @epimechfc.bsky.social · 16/09/2026

Eddy, C. Z., Raposo, H., Manchanda, A., Wong, R., Li, F., & Sun, B. (2021). Morphodynamics facilitate cancer cells to navigate 3D extracellular matrix. Scientific Reports, 11(1), 20434. #EpithelialMechanics www.nature.com/articles/s41...

nature.com

Morphodynamics facilitate cancer cells to navigate 3D extracellular matrix - Scientific Reports

Scientific Reports - Morphodynamics facilitate cancer cells to navigate 3D extracellular matrix

020

epithelial mechanics fan club @epimechfc.bsky.social · 15/09/2026

Ishihara, K., Mukherjee, A., Gromberg, E., Brugués, J., Tanaka, E. M., & Jülicher, F. (2022). Topological morphogenesis of neuroepithelial organoids. Nature Physics. #EpithelialMechanics www.nature.com/articles/s41...

141

epithelial mechanics fan club @epimechfc.bsky.social · 14/09/2026

Krueger, D., Spoelstra, W. K., Mastebroek, D. J., Kok, R. N. U., Wu, S., Nikolaev, M., Bannier-Hélaouët, M., Gjorevski, N., ..., Tans, S. J., & Clevers, H. (2025). Epithelial tension controls intestinal cell extrusion. Science, 389(6764), eadr875. #EpithelialMechanics www.science.org/doi/10.1126/...

061

Reposted by epithelial mechanics fan club

epithelial mechanics fan club @epimechfc.bsky.social · 12/09/2026

Hi #EpithelialMechanics friends 👋 What are you working on right now? Have you just published a paper and want to share your amazing findings with the world? We will host your Thread! 🧵 Let's amplify your science together and become part of our community! 👉 epithelialmechanics.github.io/contact/

epithelialmechanics.github.io

085

epithelial mechanics fan club @epimechfc.bsky.social · 12/09/2026

epithelialmechanics.github.io

085

epithelial mechanics fan club @epimechfc.bsky.social · 11/09/2026

De Belly, H., Paluch, E. K., & Chalut, K. J. (2022). Interplay between mechanics and signalling in regulating cell fate. Nature Reviews Molecular Cell Biology, 23(7), 465–480. #EpithelialMechanicsReview www.nature.com/articles/s41...

091

epithelial mechanics fan club @epimechfc.bsky.social · 10/09/2026

Xue, X., Sun, Y., Resto-Irizarry, A. M., Yuan, Y., Aw Yong, K. M., Zheng, Y., ..., Studer, L., & Fu, J. (2018). Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells. Nature Materials, 17(7), 633–641. #EpithelialMechanics www.nature.com/articles/s41...

070

epithelial mechanics fan club @epimechfc.bsky.social · 09/09/2026

Rembert, N., Dedenon, M., Roux, A., & Dessalles, C. A. (2026). Nematic order in cellular tissues: a standardized framework and anomalous defect dynamics. Biophysics. #EpithelialMechanics www.biorxiv.org/content/10.6...

0166

epithelial mechanics fan club @epimechfc.bsky.social · 08/09/2026

Santhosh, S., & Serra, M. (2026). Achiral Odd Mechanics in Cell Monolayers. bioRxiv, 2026-07. #EpithelialMechanics www.biorxiv.org/content/10.6...

095

Reposted by epithelial mechanics fan club

epithelial mechanics fan club @epimechfc.bsky.social · 06/09/2026

Hi! I’m @vitoryang.bsky.social, a PhD candidate studying how cells migrate collectively during development. My work focuses on cytoskeleton dynamics and Rho GTPase signalling, using Drosophila border cells as a genetically tractable in vivo model.

17416

epithelial mechanics fan club @epimechfc.bsky.social · 06/09/2026

Thanks for following along. For more such threads, follow us and join our club 👇 bsky.app/profile/epim...

010

epithelial mechanics fan club @epimechfc.bsky.social · 06/09/2026

Thanks to the labs and scientists behind these studies for advancing our understanding of invasive epithelial migration, actomyosin regulation, and Rho signaling. @vitoryang.bsky.social Cristian Marchant @polarityi3s.bsky.social Lab

160

epithelial mechanics fan club @epimechfc.bsky.social · 06/09/2026

So all there is left to answer is how RhoA/Rho1 is regulated? This paper shows that downregulation of Rho1 by RhoGAP15B stabilize protrusions and enable efficient collective migration in vivo. @vitoryang.bsky.social @polarityi3s.bsky.social www.biorxiv.org/content/10.6... bsky.app/profile/epim...

100

epithelial mechanics fan club @epimechfc.bsky.social · 06/09/2026

But what activates myosin in the first place? RhoA/Rho1 signalling activates Myosin II via ROCK, generating acto-myosin contractility that controls cortical tension, cell shape, and force transmission during collective migration. Zegers; Friedl bsky.app/profile/epim...

110

epithelial mechanics fan club @epimechfc.bsky.social · 06/09/2026

Myosin is more than a contractility motor. This paper shows that spatially patterned acto-myosin possibly ensures cell-cell communication and coordinates protrusion dynamics cells, to preserve cohesion and directionality. Mishra; @denisemontell.bsky.social bsky.app/profile/epim...

100

epithelial mechanics fan club @epimechfc.bsky.social · 06/09/2026

Collective migration depends on dynamic shape changes. This study reveals how dynamic Myosin contractility regulates epithelial clusters geometry, balancing tension and plasticity to enable movement in confined environments. @gfaranjuez.bsky.social @jocmcdonald.bsky.social bsky.app/profile/epim...

100

epithelial mechanics fan club @epimechfc.bsky.social · 06/09/2026

How do epithelial cells migrate collectively through dense tissues? This review shows that coordinated protrusion, adhesion, and force transmission allow groups of cells to move as a coherent unit during development and disease. Cheung; Horne-Badovinac bsky.app/profile/epim...

120