iiinova — where your digital self keeps evolving

Emma M. Groarke @emmamgroarke.bsky.social · 03/09/2026

Excited that I will be presenting at this excellent #MDSsm conference taking place in 🇮🇪 this year! #ESHMDS2026

Emma M. Groarke @emmamgroarke.bsky.social · 09/01/2026

Excited to see our review on #VEXAS now out in @thelancet.com A collaborative effort from our amazing NIAMS and NHLBI VEXAS team Bhavisha Patel, Peter Grayson, Alice Fike, Kaitlin Quinn, Ben Turturice www.sciencedirect.com/science/arti...

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Emma M. Groarke @emmamgroarke.bsky.social · 01/07/2025

Pleased to see our work looking at the impact of cytokine derived therapies / steroids on hematologic progression in #VEXAS led by Benjamin Turturice & Peter Grayson now published in @ard.eular.org www.sciencedirect.com/science/arti...

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Emma M. Groarke @emmamgroarke.bsky.social · 25/06/2025

Excited to see our NHLBI work on infections and immunodeficiency in patients with #telomere biology disorders now published @bloodjournal.bsky.social >1/3 had significant infection history & nearly 1/2 t-lymphopenia. Fernando Catto & Fernanda Gutierrez-Rodrigues. ashpublications.org/blood/articl...

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Reposted by Emma M. Groarke

Systems Cancer Immunology Group at KCL @kordastil.bsky.social · 07/06/2025

I’m delighted to share our latest work on severe aplastic anaemia, published in Nature Communications. Using advanced single-cell approaches to dissect immune-mediated marrow failure before and after immunotherapy. A great collaboration with NIH. www.nature.com/articles/s41...

nature.com

Human autoimmunity at single cell resolution in aplastic anemia before and after effective immunotherapy - Nature Communications

The transcriptional phenotype of immune cells associated with severe aplastic anaemia (SAA) may change post immunotherapy. Here the authors analyse single cell transcriptomics of hematopoietic and imm...

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Emma M. Groarke @emmamgroarke.bsky.social · 30/05/2025

Excited to share our NHLBI work led by Alice Wu in collaboration with @kingscollegelondon.bsky.social published in @natcomms.nature.com using scRNAseq and CyTOF to explore pathophysiology of immune #aplasticanemia pre and post IST. www.nature.com/articles/s41...

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Emma M. Groarke @emmamgroarke.bsky.social · 21/05/2025

Excited to share our NHLBI group’s latest work, led by post-doc Hiroki Mizumaki, looking at the role of the adaptive and innate immune system in #VEXAS in @natcomms.nature.com www.nature.com/articles/s41... Bhavisha Patel Fernanda Gutierrez-Rodrigues Neal S Young

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Emma M. Groarke @emmamgroarke.bsky.social · 19/05/2025

Congrats to FRENVEX for their study on azacitadine in #VEXAS led by Thibault Comont in @bloodjournal.bsky.social Confirmed inflammatory & hematologic responses in >50%. Molecular responses in >2/3rds! Toxicity common especially in first 3 cycles. ashpublications.org/blood/articl...

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Emma M. Groarke @emmamgroarke.bsky.social · 09/05/2025

The NIH goslings making an appearance this spring 🌸🪿

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Emma M. Groarke @emmamgroarke.bsky.social · 07/05/2025

New multi center phase 2 study in @bloodadvances.bsky.social looking again at the role of eltrombopag in pediatric #SAA - overall underwhelming in the treatment naive setting. Possible role in relapsed/refractory though very low numbers ashpublications.org/bloodadvance...

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Reposted by Emma M. Groarke

NEJM.org @nejm.org · 30/04/2025

In a new editorial, Dr. Mary Frances McMullin explores the scientific foundations and clinical implications of a study on variant EPO and erythrocytosis. Read the editorial: nej.md/3YmAnNU @qubelfastofficial.bsky.social #MedSky #Hematology

Science behind the Study
Erythrocytosis and Variants of EPO

An illustrated diagram of erythropoietin signaling.

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Reposted by Emma M. Groarke

NEJM.org @nejm.org · 27/04/2025

Both clonal hematopoiesis of indeterminate potential (CHIP) and cancer are more common with age. When they coexist in the same patient, CHIP cells may migrate to the tumor and have an adverse effect on overall survival. Full study results: nej.md/3EnzMVu #MedSky #Hematology

A schematic representation of clonal hematopoiesis of indeterminate potential (CHIP) and tumor-infiltrating clonal hematopoiesis (TI-CH) in a patient with lung cancer.

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Emma M. Groarke @emmamgroarke.bsky.social · 16/04/2025

Happy birthday to the OG NHLBI #BMFsm team! Dr. Neal S Young, staff scientist Dr. Sachiko Kajigaya and research nurse Olga Rios who have spent the last few decades at the NIH driving a clinical and translational research program which has led to astonishing progress in #SAA and other marrow failures

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Emma M. Groarke @emmamgroarke.bsky.social · 15/04/2025

Very nice paper published in @natmedicine.bsky.social from the 🇮🇹 San Raffaele group showing upregulation of inflammatory and senescence markers in #VEXAS HSPCs with exhaustion of surrounding wild type cells. www.nature.com/articles/s41...

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Emma M. Groarke @emmamgroarke.bsky.social · 07/04/2025

Excited to see this work on #clonalhematopoiesis in #telomere disorders led by @daria-babushok.bsky.social @pennmedicine.bsky.social in @jclinical-invest.bsky.social - ATM mutations commonly observed. ATM-dependent DDR from telomere dysfunction key in disease pathogenesis www.jci.org/articles/vie...

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Emma M. Groarke @emmamgroarke.bsky.social · 03/04/2025

Looking for public comments on the @ash.hematology.org #AplasticAnemia guidelines - see here! www.hematology.org/education/cl...

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Emma M. Groarke @emmamgroarke.bsky.social · 31/03/2025

Unfortunately was not able to travel to EBMT but our poster can still be viewed virtually! We report on the first 7 #VEXAS patients who underwent allo-HCT on our prospective phase II trial. High rates of #GVHD and other inflammatory complications noted. @ Bhavisha Patel

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Emma M. Groarke @emmamgroarke.bsky.social · 28/03/2025

Gene therapy for #telomere biology disorders 🧬! Report of first 2 patients @nejm.org evidence by Kas Myers using vector to increase expression of ZSCAN4 to elongate telomeres. Some TL elongation in HSPCs but low numbers. Will be interested to see more data! evidence.nejm.org/doi/pdf/10.1...

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Emma M. Groarke @emmamgroarke.bsky.social · 23/03/2025

Excited to see our NHLBI work just published in @bloodadvances.bsky.social showing the negative effects of HLA alloimmunization in #SAA patients treated with immunosuppression. Lead by our former fellow Jibran Durrani now at UMiami ashpublications.org/bloodadvance... #BMFsm

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Emma M. Groarke @emmamgroarke.bsky.social · 23/03/2025

Congrats to our former NHLBI @petermaccc.bsky.social fellow Ashvind Prabahran who led this work looking at the immune features of megakaryocytes in #BMFsm just published in @bloodadvances.bsky.social 👇 ashpublications.org/bloodadvance... #SAA

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Reposted by Emma M. Groarke

Sharon Savage @telomeredoc.bsky.social · 07/12/2024

The #CCCTAA at #ASH24. Look for important international collaborative studies on #telomere biology disorders in the near future. @teamtelomere.bsky.social is a key partner. Reach out to join the Clinical Care Consortium of Telomere Associated Ailments 🧬 #teamscience

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Emma M. Groarke @emmamgroarke.bsky.social · 26/12/2024

Happy Christmas to all from Ireland! 🇮🇪 🎄

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Emma M. Groarke @emmamgroarke.bsky.social · 09/12/2024

Congrats to Denis O’Keeffe from UHL for presenting the result of the 🇮🇪ish collaborative TILLIRI study - looking at #VTE prophylaxis in lower limb injuries. @ash-hematology.bsky.social #ASH24 @fniainle.bsky.social

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Emma M. Groarke @emmamgroarke.bsky.social · 09/12/2024

Congrats to NHLBI‘s John Tisdale for winning the @ash-hematology.bsky.social #ASH24 Beutler Prize! #SCD #ASHKudos

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Emma M. Groarke @emmamgroarke.bsky.social · 09/12/2024

Former NHLBI fellow Jibran Durrani (now @miamirosenstiel.bsky.social) presenting our group’s work on complement mediated immune activation in #SAA with HLA alloimmunisation. #ASH24 @ash-hematology.bsky.social

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Emma M. Groarke @emmamgroarke.bsky.social · 09/12/2024

Check out my NHLBI colleague Bhavisha Patel‘s poster reporting our work in patient reported outcomes in #VEXAS. Patients reported high symptom burden. #ASH24 @ash-hematology.bsky.social

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Emma M. Groarke @emmamgroarke.bsky.social · 08/12/2024

Very nice talk from Yael Kusne from Mayo Clinic on the the increased incidence of lymphoid and solid malignancies in patients with #DDX41 #IBMFS #BMFsm #ASH24 @ash-hematology.bsky.social

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Emma M. Groarke @emmamgroarke.bsky.social · 08/12/2024

Amazing talk from our NHLBI fellow Nick Lee presenting long-term results from our high-dose Danazol protocol for patients with #TBD. #ASH24 @ash-hematology.bsky.social

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Emma M. Groarke @emmamgroarke.bsky.social · 08/12/2024

Check out our former NHLBI fellow (now at @miamirosenstiel.bsky.social!) JibranDurrani’s #ASH24 poster looking at more selective JAKi in our immune BMF model. @ash-hematology.bsky.social #BMFsm

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Emma M. Groarke @emmamgroarke.bsky.social · 08/12/2024

Meeting with my Irish 🇮🇪 contingent at #ASH24! @ash-hematology.bsky.social Nina Orfali and Paul Browne

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Emma M. Groarke @emmamgroarke.bsky.social · 08/12/2024

Zoe McQuilten from Monash 🇦🇺presenting the final results of the Diaamond-AVA-first looking at hATG, CSA, and avatromboag. Similar results to eltrombopag seen. #ASH24 @ash-hematology.bsky.social

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Emma M. Groarke @emmamgroarke.bsky.social · 08/12/2024

Final results of the EBMT RACE study randomizing hATG/CSA/EPAG v IST alone. Promising long-term data! @ash-hematology.bsky.social #ASH24 #BMFsm

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Emma M. Groarke @emmamgroarke.bsky.social · 08/12/2024

Interesting data from King’s College London looking at autologous Treg cells in #AA - persistent st 6 months with responses in some patients. #ASH24 @ash-hematology.bsky.social

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Emma M. Groarke @emmamgroarke.bsky.social · 07/12/2024

Interesting talk from Olivier Hermine from Necker, Paris looking at the mechanisms underlying erythroblastopenia in #VEXAS - possible role of defects in ubiquitination and ribosomes. #ASH24 @ash-hematology.bsky.social

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Emma M. Groarke @emmamgroarke.bsky.social · 07/12/2024

Excellent talk from colleague Zhijie Wu who presented our lab’s data on T-cell clonality and dynamics after IST in #SAA. #ASH24 @ash-hematology.bsky.social #BMFsm

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Emma M. Groarke @emmamgroarke.bsky.social · 07/12/2024

Very interesting talk from Carlos Bravo-Perez looking at the relevance of variants in thrombotic / complement related genes in #PNH. #ASH24 @ash-hematology.bsky.social

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Emma M. Groarke @emmamgroarke.bsky.social · 07/12/2024

Very nice talk from Austin Kulasekararaj from King’s College London on #ClonalHematopoiesis from the the EBMT RACE trial. #BMFsm #ASH24 @ash-hematology.bsky.social

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Emma M. Groarke @emmamgroarke.bsky.social · 07/12/2024

Amazing talk from Fernanda Gutierrez-Rodrigues showing our lab’s work on #ClonalHematopoiesis over 10+ years after IST. We saw long-term clonal persistence of ASXL1 and PIGA. #ASH24 @ash-hematology.bsky.social

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Emma M. Groarke @emmamgroarke.bsky.social · 07/12/2024

An exciting #BMFsm oral session now starting in Room 11! Moderated by Bhavisha Patel and Antonio Risitano. #ASH24 @ash-hematology.bsky.social Everyone stop by!

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Reposted by Emma M. Groarke

Dr. David J. Young, MD PhD @drdavidjyoung.bsky.social · 07/12/2024

Shameless shoutout to the #RUNX1 Natural History Program of NHGRI as presented by Erica Bresciani. It’s my absolute pleasure to be a part of the program bringing together amazing patients and collaborators to study #RUNX1FPD #ASH24

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Reposted by Emma M. Groarke

Sharon Savage @telomeredoc.bsky.social · 07/12/2024

Saving the best (but I “may” be biased) for last in #ASH24 germline workshop - Dr. Maryam Rafati from #NCI_ClinicalGenetics presenting on heterozygous #DNA repair gene variants & #HCT outcomes. MUTYH carriers had poorer outcomes if received #TBI Collab w/ #CIBMTR

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Emma M. Groarke @emmamgroarke.bsky.social · 07/12/2024

Obligatory #ASH24 sign photograph! Are Fernanda and I blood 🩸 themed or Christmas 🎄 themed or both? #fASHion @ash-hematology.bsky.social

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Emma M. Groarke @emmamgroarke.bsky.social · 07/12/2024

Provisional results at @ash-hematology.bsky.social from the the NCI clinical trial using RIC #HCT with briquilimab (anti CD117) for patients with #GATA2. #BMFsm @sung-yun-pai.bsky.social Dani Arnold #ASH24

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Reposted by Emma M. Groarke

Dr. David J. Young, MD PhD @drdavidjyoung.bsky.social · 06/12/2024

The Scientific Workshop on Germline Predisposition to Hematopoietic Malignancies and Bone Marrow Failure is always must-see cutting edge science in understanding the interface of marrow disease and malignancy #ASH24 #HemeSky #BMFS

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Emma M. Groarke @emmamgroarke.bsky.social · 06/12/2024

The scientific workshop on germline predisposition to hematologic malignancy and BMF is starting! Looks to be an exciting session with specific emphasis on #RUNX1 and #DDX41 @ash-hematology.bsky.social #ASH24

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Emma M. Groarke @emmamgroarke.bsky.social · 06/12/2024

The most impressive ribbon trail I have seen so far belongs to NHLBI’s Cindy Dunbar! #ASH24 @ash-hematology.bsky.social

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Emma M. Groarke @emmamgroarke.bsky.social · 06/12/2024

Opening session of #ASH24 - the IPIG #PNH group. My colleague Fernanda Gutierrez-Rodrigues received the IPIG ASH abstract award! Check out her presentation at the #BMFsm oral session tomorrow morning. @ash-hematology.bsky.social

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