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elainetao.bsky.social

@elainetao.bsky.social
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phd-ing @corrylab.bsky.social @scienceanu.bsky.social

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Ciara Wallis @ciarawallis.bsky.social · 21/01/2025
I'm so excited to have been part of this very fun project in collaboration with the Zhang lab! 💻💙 Please check out our preprint on this beautiful channel-like protein called XPR1 here at www.biorxiv.org/content/10.1...
biorxiv.org
KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1
XPR1 is emerging as the only known inorganic phosphate (Pi) exporter in humans, critical for Pi homeostasis, with its activity stimulated by inositol pyrophosphate InsP8 and regulated by neuronal scaf...
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Reposted by @elainetao.bsky.social
corrylab.bsky.social @corrylab.bsky.social · 21/01/2025
Proud of our latest work w/ the Zhang lab showing from structure & simulation how XPR1, the only known human Pi exporter, is regulated by InsP8 & KIDINS220 + Pi selection & permeation through a channel-like “knock-kiss-kick” mechanism 🚪💋🦵 💻 by @ciarawallis.bsky.social & @riottowow.bsky.social
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Reposted by @elainetao.bsky.social
Channels, Receptors & Transporters Subgroup of BPS @bpscrt.bsky.social · 19/01/2025
The Channels, Receptors & Transporters Subgroup of the @biophysicalsoc.bsky.social is excited to announce the final program for our 2025 Symposium. Please join us on Feb 15 to hear from @willowcoyote.bsky.social @drcontrexin.bsky.social @corrylab.bsky.social and others 👇Thanks to our sponsors!
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Journal of General Physiology @jgp.org · 09/01/2025
Commentary from @willppk.bsky.social on a new study by @elainetao.bsky.social and @corrylab.bsky.social (buff.ly/4gXybTY) that uses an enhanced sampling method, metadynamics, to identify and classify Naᵥ channel blockers. buff.ly/4fJq8ck #IonChannels
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Journal of General Physiology @jgp.org · 08/01/2025
New: @elainetao.bsky.social and @corrylab.bsky.social‬ investigate the binding of sodium channel inhibitors to the Naᵥ1.5 pore using simulations, revealing promiscuous, polyspecific binding at the fenestrations and central cavity. buff.ly/40rLqHb
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Reposted by @elainetao.bsky.social
corrylab.bsky.social @corrylab.bsky.social · 08/01/2025
Excited to start the year with this paper with @elainetao.bsky.social. Using simulations we show sodium channel blocking drugs bind at many sites within the pore and fenestrastions rather than at a single distinct pose. @jgenphysiol.bsky.social @scienceanu.bsky.social #ionchannels hubs.la/Q031spy70
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Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore
Tao and Corry investigate how the binding of sodium channel inhibitors to the Nav1.5 pore using simulations reveal promiscuous, polyspecific binding at the
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