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Ewen Calder

@ecalder.bsky.social
739 followers 2.3K following 3 posts

Chancellor's Fellow at the University of Edinburgh. Part of the School of Chemistry and the Chemistry hub at the Institute for Regeneration and Repair. Interests include all things chemical biology and mRNA display. All views are my own. (He/Him)

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Reposted by Ewen Calder
Jack Williams @jackpcw.bsky.social · 23/06/2026
Cis-regulatory strategies in developmental patterning - a new review written by me and @joadelas.bsky.social is out! We discuss how two distinct cis-regulatory strategies, differential accessibility and differential binding, direct cell fate, and spatial and temporal patterning during development.
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IRR Chemistry Hub @irrchemistryhub.bsky.social · 17/10/2025
Congrats to Dr Haresh Bhaskar on passing his viva! Thanks to Aleks Ponjavic and @ecalder.bsky.social for examining!
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Reposted by Ewen Calder
Ben Schumann @drglycoben.bsky.social · 07/10/2025
Check out our new preprint "Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase" on Chemrxiv led by Will Browne in close collab with GSK @jtbush.bsky.social chemrxiv.org/engage/chemr...
chemrxiv.org
Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase
O-GalNAc (N-acetylgalactosaminyl) glycosylation is an abundant posttranslational modification in mammalian cells. Dysregulation of O-GalNAc glycosylation is implicated in cancer metastasis and immune ...
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Conway Group @conway-group.bsky.social · 25/09/2025
Hypoxia-activated PROTACs (HAP-TACs) are online in @jacs.acspublications.org (pubs.acs.org/doi/10.1021/...)! Collborative work with Ester Hammond (@hammond-lab.bsky.social). Congrats to Marta Serafini, Sophie Twigger, George Delfas, Max Mallerman, Elliot Bailey & Ewen Calder (@ecalder.bsky.social).
pubs.acs.org
Indolequinone-Based Hypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade BRD4 in Hypoxic Cancer Cells
Proteolysis targeting chimeras (PROTACs) have helped to establish proximity induction as an exciting strategy in drug discovery, and there are multiple clinical trials focused on this modality. Howeve...
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Jochen Brandt @jochenbrandt.bsky.social · 09/07/2025
PhD position available! #ChemSky #PiSky This project is highly interdisciplinary, using organic synthesis to work towards room-temperature quantum technologies. www.findaphd.com/phds/project... The funding is for Home Fee students, and covers 4 years at the UKRI rate (£22,780 tax free for 2025/26).
media.tenor.com
a dog wearing glasses and a lab coat looks at a beaker under a microscope
ALT: a dog wearing glasses and a lab coat looks at a beaker under a microscope
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RSC Chemical Biology @rscchembio.rsc.org · 16/04/2025
We’re pleased to announce our latest Emerging Investigators article collection, highlighting work from outstanding early career researchers selected from the chemical biology community. Discover this exciting work, all #openaccess and free to read, at rsc.li/CBEMI24.
A collage of portrait photos of the contributors to the collection.
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Reposted by Ewen Calder
Charlie McTernan @charliemcternan.bsky.social · 17/04/2025
Join our lab, as a SLRS/PLRS @crick.ac.uk /KCL -Synthetic Chemist/Chemical Biologist #chemsky #chembio, to lead project, build teams, support and train, collaborating across my group and more widely, driving forward basic+translational science tinyurl.com/4f4zhw9d closes 29/4! 24month, possible extn
tinyurl.com
Senior/ Principal Laboratory Research Scientist
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Ewen Calder @ecalder.bsky.social · 03/04/2025
PhD opportunity available in my lab @edinuni-irr.bsky.social and @edinburghchem.bsky.social. Developing chemical tools for Ubiquitin-like proteins. 3.5 years and would be a good fit for a molecular sciences (chem/bio) background. tinyurl.com/5h5xz93r #chembiosky
lknd.in
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Charlie McTernan @charliemcternan.bsky.social · 27/02/2025
Last call to join our lab @crick.ac.uk /KCL - looking for a Chemical Biologist/Biologist #chemsky #chembio, to lead our chemical biology/biology work, collaborating across my group and more widely, driving forward basic+translational science tinyurl.com/5n8d6ufb closes 2/3! 24month, possible extn.
tinyurl.com
Postdoctoral Research Associate at King's College London
Recruiting now: Postdoctoral Research Associate on jobs.ac.uk. Click for details and explore more academic job opportunities on the top job board
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Luciano A. Masullo @lumasullo.bsky.social · 10/02/2025
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy www.biorxiv.org/content/10.1...
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Deborah Sneddon @d-sneddon.bsky.social · 17/01/2025
Up to 11 fully funded EPSRC PhD projects in various areas of Chemistry are available (including me!). See the link below. Details of projects can be found in the brochure at the bottom of the webpage. Deadline 14 Feb. tinyurl.com/mu4xmfcp
tinyurl.com
EPSRC Science and Engineering studentships : University of Sussex
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George Biggs @george-biggs.bsky.social · 10/01/2025
Excited to share a key part of my postdoctoral work from @crick.ac.uk and GSK, published in Nature Communications. A collaborative project to develop a high-throughput chemoproteomics platform for profiling cysteine-reactive fragments in native biological systems. www.nature.com/articles/s41...
nature.com
Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics - Nature Communications
This paper presents a label-free chemoproteomics platform using data-independent acquisition to profile covalent fragment binding across the human proteome. The platform offers high reproducibility an...
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Ewen Calder @ecalder.bsky.social · 10/12/2024
Are you a chemist or biologist who wants to do an interdisciplinary #PhD? Want to use mRNA display and super resolution microscopy in the context of neurodegenerative disease? Apply for this EastBio project to work at @edinuni-irr.bsky.social @edinburghchem.bsky.social tinyurl.com/nctx5z4r
tinyurl.com
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Thorn-Seshold Lab @thornsesholdlab.bsky.social · 17/11/2024
📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange
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Reposted by Ewen Calder
Michael Booth @drmikebooth.bsky.social · 14/11/2024
The annual Royal Society of Chemistry Chemical Biology and Bioorganic Group Forum will be in Bristol next year (18th Feb)! Talks spots are open to new group leaders and postdocs - so get your abstracts in by 8th December! Please share 🙏 🧪 #chemsky www.rsc.org/events/detai...
rsc.org
2025 RSC Chemical Biology and Bio-Organic Group (CBBG) Forum
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